Research graph
References from Integrated Single-cell and Bulk Transcriptome Analysis Characterizes a Candidate Ccl4/Lgals3/Egr1 Expression Pattern Associated with Immunometabolic Dysregulation in Traumatic Brain Injury. Local targets link to admitted publications; unresolved targets remain external evidence.
Estimating the global incidence of traumatic brain injury
10.3171/2017.10.jns17352 · 2019 · External reference
Global, regional and national burden of traumatic brain injury and spinal cord injury, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
10.1136/bmjopen-2023-075049 · 2023 · External reference
Traumatic brain injury: progress and challenges in prevention, clinical care, and research
10.1016/s1474-4422(22)00309-x · 2022 · External reference
Management of moderate to severe traumatic brain injury: an update for the intensivist
10.1007/s00134-022-06702-4 · 2022 · External reference
Neurotrauma and Intracranial Pressure Management
10.1016/j.ccc.2022.08.002 · 2023 · External reference
Highlights in traumatic brain injury research in 2023
10.1016/s1474-4422(23)00458-1 · 2024 · External reference
Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia
10.1523/jneurosci.2469-20.2020 · 2021 · External reference
Neuroinflammation and blood-brain barrier disruption following traumatic brain injury: Pathophysiology and potential therapeutic targets
10.1002/jnr.24331 · 2020 · External reference
Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets
10.1007/s12031-021-01841-7 · 2021 · External reference
Traumatic Brain Injury: A Comprehensive Review of Biomechanics and Molecular Pathophysiology
10.1016/j.wneu.2024.01.084 · 2024 · External reference
Microglial Activation in Traumatic Brain Injury
10.3389/fnagi.2017.00208 · 2017 · External reference
Microglia-mediated neuroinflammation in traumatic brain injury: a review
10.1007/s11033-024-09995-4 · 2024 · External reference
Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury
10.1111/jnc.15959 · 2023 · External reference
Highlights in traumatic brain injury research in 2024
10.1016/s1474-4422(24)00477-0 · 2025 · External reference
Interacting chemokine signals regulate dendritic cells in acute brain injury
10.1371/journal.pone.0104754 · 2014 · External reference
A role for decorin in improving motor deficits after traumatic brain injury
10.1016/j.matbio.2023.12.005 · 2024 · External reference
Single cell molecular alterations reveal target cells and pathways of concussive brain injury
10.1038/s41467-018-06222-0 · 2018 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data
2023 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
10.1007/978-3-319-24277-4
10.1007/978-3-319-24277-4 · 2016 · External reference
Complex heatmap visualization
10.1002/imt2.43 · 2022 · External reference
VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
10.1186/1471-2105-12-35 · 2011 · External reference
clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
2021 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
Inference of immune cell composition on the expression profiles of mouse tissue
2017 · External reference
Unresolved reference
External reference
Tannic Acid-Based Injectable Hydrogel Promotes the Recovery of Traumatic Brain Injury by Anti-Ferroptosis
10.1021/acsami.5c02580 · 2025 · External reference
Microglia transcriptional states and their functional significance: Context drives diversity
10.1016/j.immuni.2025.04.009 · 2025 · External reference
EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death
10.3390/v14061210 · 2022 · External reference
Egr1 Is Necessary for Forebrain Dopaminergic Signaling during Social Behavior
10.1523/eneuro.0035-22.2022 · 2022 · External reference
10.1080/15548627.2026.2693261
10.1080/15548627.2026.2693261 · External reference
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males
10.1038/s41467-023-39857-9 · 2023 · External reference
Early activation of Egr-1 promotes neuroinflammation and dopaminergic neurodegeneration in an experimental model of Parkinson's disease
10.1016/j.expneurol.2018.01.009 · 2018 · External reference
Early Growth Response Protein 1 Knockdown Alleviates the Cerebral Injury in Rats with Intracerebral Hemorrhage via STAT3/NF-κB Pathway by Reducing RXRα Acetylation Level
10.1016/j.neuroscience.2021.02.011 · 2022 · External reference
Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5
10.1038/s41419-025-07501-7 · 2025 · External reference
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
10.1007/s10456-024-09922-y · 2024 · External reference
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
10.1016/j.neuron.2023.04.006 · 2023 · External reference
Microglial cytokines poison neuronal autophagy via CCR5, a druggable target
10.1080/15548627.2023.2221921 · 2024 · External reference
CCR5 regulates Aβ(1-42)-induced learning and memory deficits in mice
10.1016/j.nlm.2024.107890 · 2024 · External reference
CCL4/CCR5 regulates chondrocyte biology and OA progression
10.1016/j.cyto.2024.156746 · 2024 · External reference
Cyclosporine as Therapy for Traumatic Brain Injury
10.1007/s13311-023-01414-z · 2023 · External reference
Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy
10.1089/neu.2015.4122 · 2016 · External reference
Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis
10.1016/j.clim.2022.108939 · 2022 · External reference
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation
10.1016/j.celrep.2015.02.012 · 2015 · External reference
Emerging role of galectin 3 in neuroinflammation and neurodegeneration
10.4103/1673-5374.391181 · 2024 · External reference
The role of Galectin-3 in α-synuclein-induced microglial activation
2014 · External reference
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease
10.1007/s00401-019-02013-z · 2019 · External reference
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
10.1016/j.immuni.2018.11.004 · 2019 · External reference
Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer's disease
10.1007/s00401-022-02469-6 · 2022 · External reference
Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration
10.1523/jneurosci.2312-22.2023 · 2023 · External reference
DGIdb 5.0: rebuilding the drug-gene interaction database for precision medicine and drug discovery platforms
10.1093/nar/gkad1040 · 2024 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
Complex heatmap visualization
10.1002/imt2.43 · ExternalCitation · doi-reference
Neuroinflammation and blood-brain barrier disruption following traumatic brain injury: Pathophysiology and potential therapeutic targets
10.1002/jnr.24331 · ExternalCitation · doi-reference
10.1007/978-3-319-24277-4
10.1007/978-3-319-24277-4 · ExternalCitation · doi-reference
Management of moderate to severe traumatic brain injury: an update for the intensivist
10.1007/s00134-022-06702-4 · ExternalCitation · doi-reference
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease
10.1007/s00401-019-02013-z · ExternalCitation · doi-reference
Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer's disease
10.1007/s00401-022-02469-6 · ExternalCitation · doi-reference
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation
10.1007/s10456-024-09922-y · ExternalCitation · doi-reference
Microglia-mediated neuroinflammation in traumatic brain injury: a review
10.1007/s11033-024-09995-4 · ExternalCitation · doi-reference
Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets
10.1007/s12031-021-01841-7 · ExternalCitation · doi-reference
Cyclosporine as Therapy for Traumatic Brain Injury
10.1007/s13311-023-01414-z · ExternalCitation · doi-reference
Neurotrauma and Intracranial Pressure Management
10.1016/j.ccc.2022.08.002 · ExternalCitation · doi-reference
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation
10.1016/j.celrep.2015.02.012 · ExternalCitation · doi-reference
Galectin-3 regulates microglial activation and promotes inflammation through TLR4/MyD88/NF-kB in experimental autoimmune uveitis
10.1016/j.clim.2022.108939 · ExternalCitation · doi-reference
CCL4/CCR5 regulates chondrocyte biology and OA progression
10.1016/j.cyto.2024.156746 · ExternalCitation · doi-reference
Early activation of Egr-1 promotes neuroinflammation and dopaminergic neurodegeneration in an experimental model of Parkinson's disease
10.1016/j.expneurol.2018.01.009 · ExternalCitation · doi-reference
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
10.1016/j.immuni.2018.11.004 · ExternalCitation · doi-reference
Microglia transcriptional states and their functional significance: Context drives diversity
10.1016/j.immuni.2025.04.009 · ExternalCitation · doi-reference
A role for decorin in improving motor deficits after traumatic brain injury
10.1016/j.matbio.2023.12.005 · ExternalCitation · doi-reference
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
10.1016/j.neuron.2023.04.006 · ExternalCitation · doi-reference
Early Growth Response Protein 1 Knockdown Alleviates the Cerebral Injury in Rats with Intracerebral Hemorrhage via STAT3/NF-κB Pathway by Reducing RXRα Acetylation Level
10.1016/j.neuroscience.2021.02.011 · ExternalCitation · doi-reference
CCR5 regulates Aβ(1-42)-induced learning and memory deficits in mice
10.1016/j.nlm.2024.107890 · ExternalCitation · doi-reference
Traumatic Brain Injury: A Comprehensive Review of Biomechanics and Molecular Pathophysiology
10.1016/j.wneu.2024.01.084 · ExternalCitation · doi-reference
Traumatic brain injury: progress and challenges in prevention, clinical care, and research
10.1016/s1474-4422(22)00309-x · ExternalCitation · doi-reference
Highlights in traumatic brain injury research in 2023
10.1016/s1474-4422(23)00458-1 · ExternalCitation · doi-reference
Highlights in traumatic brain injury research in 2024
10.1016/s1474-4422(24)00477-0 · ExternalCitation · doi-reference
Tannic Acid-Based Injectable Hydrogel Promotes the Recovery of Traumatic Brain Injury by Anti-Ferroptosis
10.1021/acsami.5c02580 · ExternalCitation · doi-reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · ExternalCitation · doi-reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · ExternalCitation · doi-reference
Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5
10.1038/s41419-025-07501-7 · ExternalCitation · doi-reference
Single cell molecular alterations reveal target cells and pathways of concussive brain injury
10.1038/s41467-018-06222-0 · ExternalCitation · doi-reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · ExternalCitation · doi-reference
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males
10.1038/s41467-023-39857-9 · ExternalCitation · doi-reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · ExternalCitation · doi-reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · ExternalCitation · doi-reference
Microglial cytokines poison neuronal autophagy via CCR5, a druggable target
10.1080/15548627.2023.2221921 · ExternalCitation · doi-reference
10.1080/15548627.2026.2693261
10.1080/15548627.2026.2693261 · ExternalCitation · doi-reference
Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy
10.1089/neu.2015.4122 · ExternalCitation · doi-reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · ExternalCitation · doi-reference
DGIdb 5.0: rebuilding the drug-gene interaction database for precision medicine and drug discovery platforms
10.1093/nar/gkad1040 · ExternalCitation · doi-reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · ExternalCitation · doi-reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · ExternalCitation · doi-reference
Fundamental Neurochemistry Review: Microglial immunometabolism in traumatic brain injury
10.1111/jnc.15959 · ExternalCitation · doi-reference
Global, regional and national burden of traumatic brain injury and spinal cord injury, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
10.1136/bmjopen-2023-075049 · ExternalCitation · doi-reference
VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
10.1186/1471-2105-12-35 · ExternalCitation · doi-reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · ExternalCitation · doi-reference
Interacting chemokine signals regulate dendritic cells in acute brain injury
10.1371/journal.pone.0104754 · ExternalCitation · doi-reference
Egr1 Is Necessary for Forebrain Dopaminergic Signaling during Social Behavior
10.1523/eneuro.0035-22.2022 · ExternalCitation · doi-reference
Elevated Galectin-3 Is Associated with Aging, Multiple Sclerosis, and Oxidized Phosphatidylcholine-Induced Neurodegeneration
10.1523/jneurosci.2312-22.2023 · ExternalCitation · doi-reference
Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia
10.1523/jneurosci.2469-20.2020 · ExternalCitation · doi-reference
Estimating the global incidence of traumatic brain injury
10.3171/2017.10.jns17352 · ExternalCitation · doi-reference
Microglial Activation in Traumatic Brain Injury
10.3389/fnagi.2017.00208 · ExternalCitation · doi-reference
EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death
10.3390/v14061210 · ExternalCitation · doi-reference
Emerging role of galectin 3 in neuroinflammation and neurodegeneration
10.4103/1673-5374.391181 · ExternalCitation · doi-reference
