Research graph
References from ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty. Local targets link to admitted publications; unresolved targets remain external evidence.
Biomarkers for physical frailty and sarcopenia: state of the science and future developments
10.1002/jcsm.12051 · 2015 · External reference
Sarcopenia: origins and clinical relevance
10.1093/jn/127.5.990s · 1997 · External reference
10.14283/jfa.2018.35 · 2019 · Admitted local publication
Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US Task Force recommendations
10.1007/s12603-013-0362-7 · 2013 · External reference
Systematic Literature Review on the Relationship Between Biomarkers of Sarcopenia and Quality of Life in Older People
2016 · External reference
Designing Drug Trials for Frailty: ICFSR Task Force 2018
10.14283/jfa.2018.20 · 2018 · External reference
Towards an integral conceptual model of frailty
10.1007/s12603-010-0045-6 · 2010 · External reference
A global clinical measure of fitness and frailty in elderly people
10.1503/cmaj.050051 · 2005 · External reference
Searching for an operational definition of frailty: a Delphi method based consensus statement: the frailty operative definition-consensus conference project
10.1093/gerona/gls119 · 2013 · External reference
Frailty in older adults: evidence for a phenotype
10.1093/gerona/56.3.m146 · 2001 · External reference
Sarcopenia Is Recognized as an Independent Condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) Code
10.1016/j.jamda.2016.06.001 · 2016 · External reference
Implications of ICD-10 for Sarcopenia Clinical Practice and Clinical Trials: Report by the International Conference on Frailty and Sarcopenia Research Task Force
10.14283/jfa.2017.30 · 2018 · External reference
Sarcopenia as the Biological Substrate of Physical Frailty
10.1016/j.cger.2015.04.005 · 2015 · External reference
Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial
10.1007/s40520-016-0716-1 · 2017 · External reference
Operationalization of the physical frailty & sarcopenia syndrome: rationale and clinical implementation
2015 · External reference
Inflammatory signatures in older persons with physical frailty and sarcopenia: The frailty “cytokinome” at its core
10.1016/j.exger.2019.04.019 · 2019 · External reference
Elevated Plasma Growth and Differentiation Factor-15 is Associated with Slower Gait Speed and Lower Physical Performance in Healthy Community-Dwelling Adults
2019 · External reference
Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study
10.1016/j.mad.2012.05.005 · 2012 · External reference
The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates
10.1093/gerona/glu010 · 2014 · External reference
Strong Relation between Muscle Mass Determined by D3-creatine Dilution, Physical Performance and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men
2018 · External reference
Measurement of muscle mass in humans: validity of the 24-hour urinary creatinine method
10.1093/ajcn/37.3.478 · 1983 · External reference
Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans
10.1152/japplphysiol.00045.2014 · 2014 · External reference
D3 -Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass
10.1002/jcsm.12390 · 2019 · External reference
The association between muscle mass assessed by D3CR dilution with incident ADL and IADL disability in community dwelling older men
2019 · External reference
Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse
10.1016/j.exger.2015.11.010 · 2016 · External reference
Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults
10.1093/gerona/glt023 · 2014 · External reference
Salivary cortisol as a biomarker in stress research
10.1016/j.psyneuen.2008.10.026 · 2009 · External reference
Blunted diurnal cortisol pattern is associated with frailty: a cross-sectional study of 745 participants aged 65 to 90 years
10.1210/jc.2013-3079 · 2014 · External reference
Higher levels and blunted diurnal variation of cortisol in frail older women
10.1093/gerona/63.2.190 · 2008 · External reference
Association between Insulin-Like Growth Factor-1 and Frailty among Older Adults
10.1007/s12603-017-0916-1 · 2018 · External reference
Sex differences in the association between serum levels of testosterone and frailty in an elderly population: the Toledo Study for Healthy Aging
10.1371/journal.pone.0032401 · 2012 · External reference
Higher levels of endogenous estradiol are associated with frailty in postmenopausal women from the toledo study for healthy aging
10.1210/jc.2012-1271 · 2012 · External reference
Serum SIRT1 Is Associated with Frailty and Adipokines in Older Adults
10.1007/s12603-018-1149-7 · 2019 · External reference
Frailty status and altered glucose-insulin dynamics
10.1093/gerona/glr141 · 2012 · External reference
Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
10.1007/bf03324545 · 2004 · External reference
Association between endothelial dysfunction and frailty: the Toledo Study for Healthy Aging
10.1007/s11357-013-9576-1 · 2014 · External reference
Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study
10.1001/archinte.162.20.2333 · 2002 · External reference
Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly
10.1038/s41598-018-26944-x · 2018 · External reference
Metabolomics biomarkers of frailty in elderly breast cancer patients
10.1002/jcp.24520 · 2014 · External reference
Advances in geroscience: impact on healthspan and chronic disease
10.1093/gerona/glu041 · 2014 · External reference
Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity
10.1093/gerona/glu055 · 2014 · External reference
Recent progress in metabolic signaling pathways regulating aging and life span
10.1093/gerona/glu058 · 2014 · External reference
Lamin A-dependent nuclear defects in human aging
10.1126/science.1127168 · 2006 · External reference
Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging
10.1016/j.jamda.2017.04.019 · 2017 · External reference
Vaccination in the elderly: The challenge of immune changes with aging
10.1016/j.smim.2018.10.010 · 2018 · External reference
The hallmarks of aging
10.1016/j.cell.2013.05.039 · 2013 · External reference
Evolution of the immune system in humans from infancy to old age
2015 · External reference
Innovative Medicines Initiative: The SPRINTT Project
2015 · External reference
The “BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons” (BIOSPHERE) study: Rationale, design and methods
10.1016/j.ejim.2018.05.001 · 2018 · External reference
In Search of ‘Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative
10.1159/000435853 · 2016 · External reference
Use of Biomarkers
2015 · External reference
