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References from Exploring causal associations between the plasma proteome and bone mineral density: a Mendelian randomization study. Local targets link to admitted publications; unresolved targets remain external evidence.
Long-term and sequential treatment for osteoporosis
10.1038/s41574-023-00866-9 · 2023 · External reference
MRI quantification of cortical bone porosity, mineralization, and morphologic structure in postmenopausal osteoporosis
10.1148/radiol.221810 · 2023 · External reference
Global epidemiological features and impact of osteosarcopenia: a comprehensive meta-analysis and systematic review
10.1002/jcsm.13392 · 2024 · External reference
Treatment-related changes in bone mineral density as a surrogate biomarker for fracture risk reduction: meta-regression analyses of individual patient data from multiple randomised controlled trials
10.1016/s2213-8587(20)30159-5 · 2020 · External reference
Proteome-wide profiling reveals dysregulated molecular features and accelerated aging in osteoporosis: a 9.8-year prospective study
10.1111/acel.14035 · 2024 · External reference
Dual-energy x-ray absorptiometry scanner mismatch in follow-up bone mineral density testing
10.1007/s00198-022-06438-3 · 2022 · External reference
Plasma proteomic associations with genetics and health in the UK Biobank
10.1038/s41586-023-06592-6 · 2023 · External reference
A genome-wide association study of serum proteins reveals shared loci with common diseases
10.1038/s41467-021-27850-z · 2022 · External reference
Statistical methods for Mendelian randomization in genome-wide association studies: a review
10.1016/j.csbj.2022.05.015 · 2022 · External reference
Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement
10.1001/jama.2021.18236 · 2021 · External reference
Assessing the causal relationship between plasma proteins and osteoporosis: novel insights into pathological mechanisms and therapeutic implications
10.1007/s00198-024-07225-y · 2024 · External reference
Causal effects of plasma proteome on osteoporosis and osteoarthritis
10.1007/s00223-022-01049-w · 2023 · External reference
Genomic atlas of the human plasma proteome
10.1038/s41586-018-0175-2 · 2018 · External reference
Large-scale integration of the plasma proteome with genetics and disease
10.1038/s41588-021-00978-w · 2021 · External reference
Connecting genetic risk to disease end points through the human blood plasma proteome
2017 · External reference
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
10.1038/s41467-019-11177-x · 2019 · External reference
Genetic architecture of host proteins involved in SARS-CoV-2 infection
10.1038/s41467-020-19996-z · 2020 · External reference
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
10.1038/s41467-018-05512-x · 2018 · External reference
Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
10.1371/journal.pgen.1006706 · 2017 · External reference
Whole-genome sequencing analysis of the cardiometabolic proteome
10.1038/s41467-020-20079-2 · 2020 · External reference
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
10.1136/ard-2023-224459 · 2023 · External reference
Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects
10.1016/j.ajhg.2017.12.005 · 2018 · External reference
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
10.1038/nature14878 · 2015 · External reference
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
10.1038/s41588-020-0682-6 · 2020 · External reference
A more accurate method for colocalisation analysis allowing for multiple causal variants
10.1371/journal.pgen.1009440 · 2021 · External reference
The druggable genome and support for target identification and validation in drug development
10.1126/scitranslmed.aag1166 · 2017 · External reference
Bone density, geometry, microstructure, and stiffness: relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women
10.1002/jbmr.111 · 2010 · External reference
Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair
10.1016/j.bone.2015.10.005 · 2016 · External reference
F2r negatively regulates osteoclastogenesis through inhibiting the Akt and NFκB signaling pathways
10.7150/ijbs.41867 · 2020 · External reference
Bone mineral density, bone remodeling biomarkers, and hemostatic correlates in hemophilia and von Willebrand disease
10.1182/bloodadvances.2026019657 · 2026 · External reference
BIGH3 promotes osteolytic lesions in renal cell carcinoma bone metastasis by inhibiting osteoblast differentiation
10.1016/j.neo.2017.11.002 · 2018 · External reference
BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression
10.1016/j.canlet.2024.217009 · 2024 · External reference
Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method
10.1016/j.bone.2018.08.020 · 2018 · External reference
Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment
10.1038/s42003-019-0334-5 · 2019 · External reference
Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age-related bone loss in male mice
10.1002/jcp.30949 · 2023 · External reference
TSP-1 interaction with RANK and OPG: implications for bone remodeling and osteolytic bone metastasis
10.1038/s41419-026-08600-9 · 2026 · External reference
Possible involvement of HtrA1 serine protease in the onset of osteoporotic bone extracellular matrix changes
10.1016/j.tice.2024.102329 · 2024 · External reference
Loss of vlk in Prx1+ cells delays the initial steps of endochondral bone formation and fracture repair in the limb
10.1002/jbmr.4514 · 2022 · External reference
A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis
10.7554/elife.82564 · 2024 · External reference
Complement factor H (CFH), an immune factor enhances osteoblast differentiation and correlates with bone density
2026 · External reference
Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: a mediation Mendelian randomization study
10.1002/pmrj.70029 · 2026 · External reference
Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease
10.1186/s10020-024-00838-3 · 2024 · External reference
RSPO3 is important for trabecular bone and fracture risk in mice and humans
10.1038/s41467-021-25124-2 · 2021 · External reference
Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation
10.1038/s41413-026-00511-x · 2026 · External reference
Roles of circulating proteins in osteoporosis pathogenesis: insights from Mendelian randomization
10.1016/j.bone.2026.118005 · 2026 · External reference
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
10.1073/pnas.97.4.1566 · 2000 · External reference
The RANK/RANKL axis controls vascular dynamics in the bone marrow
10.1073/pnas.2425366122 · 2025 · External reference
OPN, BSP, and bone quality – structural, biochemical, and biomechanical assessment in OPN−/−, BSP−/−, and DKO mice
10.1007/s00223-024-01217-0 · 2024 · External reference