References

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

10.1038/35019108 · 2000 · External reference

PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein

10.1038/nsmb837 · 2004 · External reference

The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by RING finger domain

10.1371/journal.pone.0001776 · 2008 · External reference

The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains

10.1038/sj.onc.1206831 · 2003 · External reference

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

10.1083/jcb.200108016 · 2002 · External reference

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity

2002 · External reference

Chfr is required for tumor suppression and Aurora A regulation

10.1038/ng1538 · 2005 · External reference

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

10.1038/nature06420 · 2008 · External reference

Functional characterization of Dma1 and Dma2, the budding yeast homologues of Schizosaccharomyces pombe Dma1 and human Chfr

10.1091/mbc.e04-02-0094 · 2004 · External reference

Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN)

10.1016/s1534-5807(02)00367-2 · 2002 · External reference

The fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised

10.1002/j.1460-2075.1996.tb01051.x · 1996 · External reference

Regulation of mitotic exit by the RNF8 ubiquitin ligase

10.1038/sj.onc.1210782 · 2008 · External reference

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

10.1016/j.cell.2007.09.041 · 2007 · External reference

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

10.1016/j.cell.2007.09.040 · 2007 · External reference

Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR

2003 · External reference

The CHFR mitotic checkpoint protein delays cell cycle progression by excluding cyclin B1 from the nucleus

10.1038/sj.onc.1208428 · 2005 · External reference

Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors

10.4161/cbt.4.7.1896 · 2005 · External reference

Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer

2003 · External reference

Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression

10.1158/0008-5472.can-06-4109 · 2007 · External reference

CHFR-associated early G2/M checkpoint defects in breast cancer cells

10.1002/mc.10161 · 2004 · External reference

Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells

10.1083/jcb.200401139 · 2004 · External reference

SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

10.1038/sj.onc.1209857 · 2007 · External reference

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

10.1128/mcb.24.23.10448-10455.2004 · 2004 · External reference

Loss of CHFR expression in mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint

10.1593/neo.08176 · 2008 · External reference

Discovery of candidate KEN box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservation

10.1093/bioinformatics/btm624 · 2008 · External reference

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

10.1016/s0092-8674(03)00642-1 · 2003 · External reference

Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity

10.1016/j.bbrc.2007.03.193 · 2007 · External reference

Chfr inactivation is not associated to chromosomal instability in colon cancers

10.1038/sj.onc.1207078 · 2003 · External reference

Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer

2003 · External reference

Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk

10.1016/j.canlet.2007.10.036 · 2008 · External reference

Epigenetic inactivation of CHFR in human tumors

10.1073/pnas.1337066100 · 2003 · External reference

Array CGH profiling of favourable histology Wilms tumors reveals novel gains and losses associated with relapse

10.1002/path.2021 · 2006 · External reference

Increased chromosomal imbalances in recurrent pituitary adenomas

10.1007/s004010100413 · 2001 · External reference

Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma

10.1038/labinvest.3700314 · 2005 · External reference

Chromosomal imbalances are associated with metastasis-free survival in breast cancer patients

10.1155/2002/820269 · 2002 · External reference

Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer

2000 · External reference

Inhibition of prostate cancer metastatic colonization by approximately 4.2 Mb of human chromosome 12

10.1002/ijc.11483 · 2004 · External reference

Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes

2007 · External reference

CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype

10.1093/carcin/bgi058 · 2005 · External reference

Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma

10.1001/archotol.133.11.1131 · 2007 · External reference

Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation

10.1002/mc.20106 · 2005 · External reference

Frequent hypermethylation of the 5′ CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer

10.1093/carcin/24.1.47 · 2003 · External reference

Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations

10.1093/carcin/bgm270 · 2008 · External reference

Methylation of gene CHFR promoter in acute leukemia cells

2005 · External reference

Sequential gene promoter methylation during HPV-induced cervical carcinogenesis

10.1038/sj.bjc.6604055 · 2007 · External reference

Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias

10.1007/s00428-004-1146-6 · 2005 · External reference

Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia

10.1038/sj.bjc.6601849 · 2004 · External reference

DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis

10.1038/labinvest.3700707 · 2008 · External reference

Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers

2004 · External reference

CpG island methylator phenotype-low (CIMP-low) colorectal cancer shows not only few methylated CIMP-high-specific CpG islands, but also low-level methylation at individual loci

10.1038/modpathol.3800982 · 2008 · External reference

The significance of aberrant CHFR methylation for clinical response to microtubule inhibitors in gastric cancer

10.1007/s00535-005-1732-7 · 2006 · External reference

CHFR gene is neither mutated nor hypermethylated in ovarian cancer

10.1016/j.cdp.2006.04.005 · 2007 · External reference

Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers

10.1038/sj.onc.1205402 · 2002 · External reference

Aberrant methylation of the CHFR gene is frequently detected in noninvasive colorectal cancer

2006 · External reference

Aberrant methylation of the CHFR gene in digestive tract cancer

2006 · External reference

Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma

2005 · External reference

Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer

10.1093/carcin/23.10.1695 · 2002 · External reference

Aberrant hypermethylation of the promoter region of the CHFR gene is rare in primary breast cancer

10.1007/s10549-005-9112-9 · 2006 · External reference

Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients

10.1111/j.1349-7006.2004.tb03254.x · 2004 · External reference

Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73

2005 · External reference

Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer

2007 · External reference

DNA methylation of CHFR is not a predictor of the response to docetaxel and paclitaxel in advanced and recurrent gastric cancer

2006 · External reference

Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis

10.1016/j.humpath.2006.12.010 · 2007 · External reference

Aberrant expression of CHFR in malignant peripheral nerve sheath tumors

10.1038/modpathol.3800548 · 2006 · External reference