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References from Differential Effects of the Proteasome Inhibitor NPI-0052 against Glioma Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
10.1056/nejmoa043330 · 2005 · External reference
Protein degradation and protection against misfolded or damaged proteins
10.1038/nature02263 · 2003 · External reference
The ubiquitin-proteasome pathway in cancer
10.1038/bjc.1998.71 · 1998 · External reference
The regulation of proteasome degradation by multiubiquitin chain binding proteins
10.1016/j.febslet.2005.03.042 · 2005 · External reference
The proteasome in cancer biology and treatment
10.1667/0033-7587(2001)156[0447:tpicba]2.0.co;2 · 2001 · External reference
Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy
10.1634/theoncologist.8-6-508 · 2003 · External reference
Bortezomib for the treatment of mantle cell lymphoma
10.1158/1078-0432.ccr-07-0871 · 2007 · External reference
Cytotoxic and apoptotic effects of bortezomib and gefitinib compared to alkylating agents on human glioblastoma cells
2008 · External reference
Proteasome inhibition by bortezomib does not translate into efficacy on two malignant glioma xenografts
2008 · External reference
Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies
10.1016/j.ijrobp.2008.08.050 · 2008 · External reference
Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
10.1002/anie.200390115 · 2003 · External reference
Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor
10.1021/jm048995+ · 2005 · External reference
The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia
10.1158/1535-7163.mct-06-0066 · 2006 · External reference
A novel proteasome inhibitor NPI-0052 as an anticancer therapy
10.1038/sj.bjc.6603406 · 2006 · External reference
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
10.1016/s1470-2045(09)70025-7 · 2009 · External reference
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
10.1038/nature07385 · 2008 · External reference
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
10.1016/j.ccr.2005.10.013 · 2005 · External reference
The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism
10.1186/1471-2407-5-76 · 2005 · External reference
The proteasome inhibitor MG-132 protects hypoxic SiHa cervical carcinomacells after cyclic hypoxia/reoxygenation from ionizing radiation
10.1593/neo.06634 · 2006 · External reference
The human immunodeficiency virus (HIV)-1 protease inhibitor saquinavir inhibits proteasome function and causes apoptosis and radiosensitization in non-HIV-associated human cancer cells
2002 · External reference
Apoptosis and radiosensitization of hodgkin cells by proteasome inhibition
10.1016/s0360-3016(00)00516-2 · 2000 · External reference
Molecular pathways that modify tumor radiation response
10.1097/00000421-200110000-00013 · 2001 · External reference
Phase I study of bortezomib with weekly paclitaxel in patients with advanced solid tumours
10.1016/j.ejca.2008.05.022 · 2008 · External reference
Phase I study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor
10.1038/sj.bjc.6605043 · 2009 · External reference
A phase I study of bortezomib, etoposide and carboplatin in patients with advanced solid tumors refractory to standard therapy
10.1007/s10637-008-9154-z · 2009 · External reference
Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)
10.1038/sj.onc.1208225 · 2005 · External reference
Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines
10.1016/j.ijrobp.2007.07.2366 · 2007 · External reference
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
10.1016/j.stem.2009.01.007 · 2009 · External reference
Delivery of PTEN via a novel gene microcapsule sensitizes prostate cancer cells to irradiation
10.1158/1535-7163.mct-07-2198 · 2008 · External reference
Combination of PTEN and gamma-ionizing radiation enhances cell death and G(2)/M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells
10.1016/j.ijrobp.2007.11.069 · 2008 · External reference
Survival of human glioma cells treated with various combination of temozolomide and x-rays
10.1016/s0360-3016(99)00539-8 · 2000 · External reference
Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer
1999 · External reference
Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapy in the A549 non-small-cell lung cancer cell line
10.1007/s00280-004-0811-4 · 2004 · External reference
DNA repair and cancer stem-like cells—potential partners in glioma drug resistance?
10.1016/j.ctrv.2008.03.125 · 2008 · External reference
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
1998 · External reference
In-vivo imaging, tracking, and targeting of cancer stem cells
10.1093/jnci/djn509 · 2009 · External reference