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References from Inhibition of the MET Receptor Tyrosine Kinase as a Novel Therapeutic Strategy in Medulloblastoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Medulloblastoma: a population-based study of 532 cases
10.1097/00005072-199103000-00005 · 1991 · External reference
The epidemiology of primary intracranial neoplasms of childhood. A population study
1976 · External reference
Medulloblastoma: clinical presentation and management. Experience at the Hospital for Sick Children, Toronto, 1950–1980
10.3171/jns.1983.58.4.0543 · 1983 · External reference
Cognitive deficits in long-term survivors of childhood brain tumors
10.1007/bf00263824 · 1991 · External reference
Late effects of treatment on the intelligence of children with posterior fossa tumors
10.1002/1097-0142(19830115)51:2<233::aid-cncr2820510211>3.0.co;2-8 · 1983 · External reference
Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study
10.1200/jco.1998.16.5.1723 · 1998 · External reference
Dose dependency of time of onset of radiation-induced growth hormone deficiency
10.1016/s0022-3476(05)80487-1 · 1991 · External reference
Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth
10.1158/0008-5472.can-08-1899 · 2008 · External reference
An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma
10.1158/0008-5472.can-08-2169 · 2008 · External reference
Functional and molecular interactions between the HGF/c-Met pathway and c-Myc in large-cell medulloblastoma
10.1038/labinvest.3700702 · 2008 · External reference
The scatter factor/hepatocyte growth factor: c-met pathway in human embryonal central nervous system tumor malignancy
10.1158/0008-5472.can-05-1946 · 2005 · External reference
c-Met activation in medulloblastoma induces tissue factor expression and activity: effects on cell migration
10.1093/carcin/bgp085 · 2009 · External reference
PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growthfactor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells
10.1186/1471-2407-9-411 · 2009 · External reference
Drug development of MET inhibitors: targetingoncogene addiction and expedience
10.1038/nrd2530 · 2008 · External reference
Targeting the c-Met signaling pathway in cancer
10.1158/1078-0432.ccr-06-0818 · 2006 · External reference
HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice
2000 · External reference
Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
10.1158/1078-0432.ccr-05-1793 · 2006 · External reference
Mechanisms and significance of bifunctional NK4 in cancer treatment
10.1016/j.bbrc.2005.05.131 · 2005 · External reference
An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice
10.1172/jci22235 · 2004 · External reference
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors
10.1158/0008-5472.can-05-3329 · 2006 · External reference
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
10.1016/j.ccr.2004.05.032 · 2004 · External reference
Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte growth factor: c-Met-dependent tumors in animal models
10.1158/1535-7163.mct-08-1032 · 2009 · External reference
Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models
10.1073/pnas.131200498 · 2001 · External reference
A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo
10.1158/1078-0432.ccr-05-1418 · 2006 · External reference
Small molecule tyrosine kinase inhibitors: clinicaldevelopment of anticancer agents
10.1517/13543784.12.1.51 · 2003 · External reference
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-) p53(-/-) mice
10.1016/j.ccr.2004.08.019 · 2004 · External reference
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion
2003 · External reference
c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations
10.1074/jbc.m705774200 · 2008 · External reference
A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo
2003 · External reference
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lungcancer xenografts
10.1158/0008-5472.can-06-4416 · 2007 · External reference
Inhibition of c-Met as a therapeutic strategy for esophageal adenocarcinoma
10.1593/neo.06499 · 2006 · External reference
A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits
1987 · External reference
Expression of major histocompatibility complex on human medulloblastoma cells with neuronal differentiation
1989 · External reference
Epigenetic silencing of the HIC-1 gene in human medulloblastomas
10.1093/jnen/62.11.1192 · 2003 · External reference
Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII
10.1016/s0021-9258(18)82167-6 · 1993 · External reference
Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
10.1215/s1152851705000050 · 2005 · External reference
Emerging multipotent aspects of hepatocyte growth factor
10.1093/oxfordjournals.jbchem.a021283 · 1996 · External reference
Met, metastasis, motility and more
10.1038/nrm1261 · 2003 · External reference
Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development
10.1073/pnas.222362099 · 2002 · External reference
Localization and functional coupling of HGF and c-Met/HGF receptor in rat brain: implication as neurotrophic factor
10.1016/0169-328x(95)00075-4 · 1995 · External reference
Expression and functional interaction of hepatocyte growth factor-scatter factor and its receptor c-met in mammalian brain
10.1083/jcb.126.2.485 · 1994 · External reference
Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the phosphatidylinositol-3 kinase/Akt pathway
10.1002/(sici)1097-4547(20000215)59:4<489::aid-jnr3>3.0.co;2-9 · 2000 · External reference
Detection of oncogene amplifications in medulloblastomas by comparative genomic hybridization and array-based comparative genomic hybridization
2004 · External reference
