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References from Anticancer Activity of a Broccoli Derivative, Sulforaphane, in Barrett Adenocarcinoma: Potential Use in Chemoprevention and as Adjuvant in Chemotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Multi-targeted prevention of cancer by sulforaphane
10.1016/j.canlet.2008.04.018 · 2008 · External reference
Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype
10.1093/jn/134.5.1134 · 2004 · External reference
Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk
10.1207/s15327914nc5002_11 · 2004 · External reference
Brassica vegetables and cancer prevention. Epidemiology and mechanisms
10.1007/978-1-4757-3230-6_14 · 1999 · External reference
Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanate
10.1093/carcin/21.12.2287 · 2000 · External reference
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure
10.1073/pnas.89.6.2399 · 1992 · External reference
HPLC method validation for measurement of sulforaphane level in broccoli by-products
10.1002/bmc.1303 · 2010 · External reference
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
10.1073/pnas.94.19.10367 · 1997 · External reference
Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms
1994 · External reference
Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C
10.1074/jbc.m313538200 · 2004 · External reference
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
10.1093/carcin/bgl049 · 2006 · External reference
Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells
2002 · External reference
Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention
2004 · External reference
Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae
10.1016/j.mrfmmm.2006.01.007 · 2006 · External reference
Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells
10.1207/s15327914nc5202_11 · 2005 · External reference
Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
2000 · External reference
The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
10.1158/1535-7163.1239.3.10 · 2004 · External reference
Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo
10.1093/carcin/bgg178 · 2004 · External reference
Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo
2007 · External reference
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
10.1016/j.canlet.2005.09.012 · 2006 · External reference
Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
10.1158/0008-5472.can-06-0300 · 2006 · External reference
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
10.1073/pnas.112203099 · 2002 · External reference
Augmentation of natural killer cell and antibodydependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma
10.1080/08923970600928049 · 2006 · External reference
Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane
10.1080/08923970701511728 · 2007 · External reference
The changing epidemiology of esophageal cancer
1999 · External reference
Changing patterns in the incidence of esophageal and gastric carcinoma in the United States
10.1002/(sici)1097-0142(19981115)83:10<2049::aid-cncr1>3.0.co;2-2 · 1998 · External reference
10.1038/sj.neo.7900097 · 2000 · Admitted local publication
Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells
10.1111/j.1572-0241.2007.01773.x · 2008 · External reference
Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro
10.1136/gut.52.2.174 · 2003 · External reference
Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells
2007 · External reference
In vitro antiproliferative effects of sulforaphane on human colon cancer cell line SW620
10.14712/18059694.2017.78 · 2007 · External reference
Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells
2007 · External reference
Sulforaphane sensitizes tumor necrosis factor-related apoptosisinducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells
10.1093/carcin/bgl251 · 2007 · External reference
The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
10.1158/0008-5472.can-07-0340 · 2007 · External reference
Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3
2007 · External reference
Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells
2006 · External reference
Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells
10.1158/1535-7163.mct-06-0404 · 2007 · External reference
Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines
10.1158/1535-7163.mct-06-0494 · 2007 · External reference
Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells
10.1093/carcin/bgi185 · 2005 · External reference
PAK-104P, a pyridine analogue, reverses paclitaxel and doxorubicin resistance in cell lines and nude mice bearing xenografts that overexpress the multidrug resistance protein
1996 · External reference
Covalent binding to tubulin by isothiocyanates: a mechanism of cell growth arrest and apoptosis
10.1074/jbc.m802330200 · 2008 · External reference
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells
10.1093/carcin/bgi265 · 2006 · External reference
Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line
10.1158/1535-7163.mct-06-0807 · 2007 · External reference
p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1
10.1007/s00280-005-0050-3 · 2006 · External reference
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
10.1158/0008-5472.can-04-1326 · 2004 · External reference
Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line
10.1023/b:pham.0000022412.69380.d7 · 2004 · External reference
Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells
10.1016/j.bcp.2005.03.015 · 2005 · External reference
Suppression of NF-κB and NF-κB-regulated gene expression by sulforaphane and PEITC through IκBα, IKK pathway in human prostate cancer PC-3 cells
10.1038/sj.onc.1208656 · 2005 · External reference
