References

Melanoma biology and new targeted therapy

10.1038/nature05661 · 2007 · External reference

Melanoma, nevogenesis, and stem cell biology

10.1038/jid.2008.166 · 2008 · External reference

Molecular correlates of site-specific metastasis

10.1016/j.semradonc.2005.12.005 · 2006 · External reference

Targeting key steps in metastatic tumour progression

10.1016/j.gde.2004.12.001 · 2005 · External reference

Understanding signaling cascades in melanoma

10.1111/j.1751-1097.2007.00254.x · 2008 · External reference

The RAS/RAF/MEK/ERK and PI3K/AKTsignaling pathways present molecular targets for the effective treatment of advanced melanoma

10.2741/1755 · 2005 · External reference

Expression of activated extracellular signal-regulated kinases 1/2 in malignant melanomas: relationship with clinical outcome

2003 · External reference

STAT3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction

10.1593/neo.06820 · 2007 · External reference

STAT1 acts as a tumor promoter for leukemia development

10.1016/j.ccr.2006.05.025 · 2006 · External reference

STAT2 contributes to promotion of colorectal and skin carcinogenesis

10.1158/1940-6207.capr-09-0105 · 2010 · External reference

A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models

10.1074/jbc.m413309200 · 2005 · External reference

Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells

10.1007/s11060-010-0273-y · 2011 · External reference

A family of cytokine-inducible inhibitors of signalling

10.1038/43206 · 1997 · External reference

Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts

10.1073/pnas.090084797 · 2000 · External reference

The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities

10.1074/jbc.273.52.35056 · 1998 · External reference

SOCS proteins, cytokine signalling and immune regulation

10.1038/nri2093 · 2007 · External reference

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

10.1101/gad.1252404 · 2004 · External reference

SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome

10.1128/mcb.24.20.9092-9101.2004 · 2004 · External reference

Molecular basis for the critical role of suppressor of cytokine signaling-1 in melanoma brain metastasis

10.1158/0008-5472.can-08-1429 · 2008 · External reference

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

10.1093/emboj/18.5.1309 · 1999 · External reference

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity

10.1038/ng0501-29 · 2001 · External reference

SOCS1 silencing enhances antitumor activity of type I IFNs by regulating apoptosis in neuroendocrine tumor cells

10.1158/0008-5472.can-06-2575 · 2007 · External reference

Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells

10.1111/j.1349-7006.2008.00850.x · 2008 · External reference

Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

10.1186/1471-2407-10-142 · 2010 · External reference

Development of IFN-γ resistance is associated with attenuation of SOCS genes induction and constitutive expression of SOCS 3 in melanoma cells

10.1038/sj.bjc.6603849 · 2007 · External reference

Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma

10.1111/j.0022-202x.2004.23408.x · 2004 · External reference

Expression of SOCS1 and SOCS3 genes is differentially regulated in breast cancer cells in response to proinflammatory cytokine and growth factor signals

10.1038/sj.onc.1209993 · 2007 · External reference

Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases

10.2353/ajpath.2009.080751 · 2009 · External reference

Protective, anti-tumor monoclonal antibody recognizes a conformational epitope similar to melibiose at the surface of invasive murine melanoma cells

10.1089/153685902761022661 · 2002 · External reference

SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition

10.1038/sj.onc.1208818 · 2005 · External reference

Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma

10.1136/gut.2006.111633 · 2007 · External reference

Growth control of melanoma cells and melanocytes by cytokines

10.1007/978-3-642-78771-3_12 · 1995 · External reference

Molecular biology of human melanoma development and progression

10.1002/(sici)1098-2744(199811)23:3<132::aid-mc2>3.0.co;2-1 · 1998 · External reference

Malignant melanoma

10.5858/2001-125-1295-mm · 2001 · External reference

Defect of insulin receptor in insulin-resistant variants of Cloudman S91 mouse melanoma cells

10.1097/00008390-199207000-00006 · 1992 · External reference

Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation

10.1074/jbc.m202823200 · 2002 · External reference

Socs1 deficiency enhances hepatic insulin signaling

10.1074/jbc.m502163200 · 2005 · External reference

Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling

10.1242/jcs.02740 · 2006 · External reference

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

10.1038/35074525 · 2001 · External reference