Research graph
References from Glucose Metabolism Measured by [18F]Fluorodeoxyglucose Positron Emission Tomography Is Independent of PTEN/AKT Status in Human Colon Carcinoma Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
10.1038/nrc2664 · 2009 · External reference
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
10.1038/nrc1819 · 2006 · External reference
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
10.1126/science.275.5308.1943 · 1997 · External reference
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
10.1038/ng0497-356 · 1997 · External reference
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
10.1073/pnas.96.8.4240 · 1999 · External reference
Activation of Akt/protein kinase B overcomes a G(2)/M cell cycle checkpoint induced by DNA damage
10.1128/mcb.22.22.7831-7841.2002 · 2002 · External reference
Targeting the phosphoinositide 3-kinase pathway in cancer
10.1038/nrd2926 · 2009 · External reference
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
10.1038/onc.2008.246 · 2008 · External reference
Imaging the life and death of tumors in living subjects: preclinical PET imaging of proliferation and apoptosis
10.1039/c0ib00066c · 2010 · External reference
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
10.1002/jcp.20166 · 2005 · External reference
Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
10.1074/jbc.m305689200 · 2003 · External reference
Imaging of tumor glucose utilization with positron emission tomography
10.1007/s10555-008-9151-x · 2008 · External reference
Akt stimulates aerobic glycolysis in cancer cells
10.1158/0008-5472.can-03-2904 · 2004 · External reference
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
10.1101/gad.889901 · 2001 · External reference
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
10.1038/nm1052 · 2004 · External reference
Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
10.1074/jbc.m010551200 · 2001 · External reference
Akt-dependent transformation: there is more to growth than just surviving
10.1038/sj.onc.1209097 · 2005 · External reference
PTEN gene targeting reveals a radiation-induced size checkpoint in human cancer cells
10.1158/0008-5472.can-04-1767 · 2004 · External reference
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
10.1016/j.ccr.2005.05.014 · 2005 · External reference
Guidelines for the welfare and use of animals in cancer research
10.1038/sj.bjc.6605642 · 2010 · External reference
PTEN, more than the AKT pathway
10.1093/carcin/bgm052 · 2007 · External reference
PI 3-kinase, Akt and cell survival
10.1016/j.semcdb.2004.01.002 · 2004 · External reference
Essential role of AKT-1/protein kinase Bα in PTEN-controlled tumorigenesis
10.1128/mcb.22.11.3842-3851.2002 · 2002 · External reference
Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer
10.1093/carcin/bgl190 · 2007 · External reference
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
10.1128/mcb.21.6.2203-2212.2001 · 2001 · External reference
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations
10.1038/onc.2009.516 · 2010 · External reference
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
10.1038/nature03918 · 2005 · External reference
Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA
10.1128/mcb.00537-06 · 2007 · External reference
A prostatic intraepithelial neoplasia-dependent p27Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression
10.1016/j.ccr.2008.06.002 · 2008 · External reference
Targeting metabolic transformation for cancer therapy
10.1038/nrc2817 · 2010 · External reference
Understanding the Warburg effect: the metabolic requirements of cell proliferation
10.1126/science.1160809 · 2009 · External reference
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises
10.1016/j.coph.2008.08.004 · 2008 · External reference
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
10.1016/s0021-9258(17)37680-9 · 1994 · External reference
AKT1(E17K) in human solid tumours
10.1038/onc.2008.170 · 2008 · External reference
PIK3CA mutations are mutually exclusive with PTEN loss in diffuse large B-cell lymphoma
10.1038/sj.leu.2404873 · 2007 · External reference
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
10.1158/0008-5472-can-04-3913 · 2005 · External reference
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer
10.1158/1078-0432.ccr-06-1609 · 2007 · External reference
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
10.1158/0008-5472.can-07-6854 · 2008 · External reference
Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models
10.1371/journal.pone.0009305 · 2010 · External reference
Dose-response relationship in cyclophosphamide-treated B-cell lymphoma xenografts monitored with [18F]FDG PET
10.1007/s00259-010-1479-0 · 2010 · External reference
Does FDG uptake measure proliferative activity of human cancer cells? In vitro comparison with DNA flow cytometry and tritiated thymidine uptake
1993 · External reference
Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. European Organization for Research and Treatment of Cancer (EORTC) PET Study Group
10.1016/s0959-8049(99)00229-4 · 1999 · External reference
Specificity and mechanism of action of some commonly used protein kinase inhibitors
10.1042/bj3510095 · 2000 · External reference
Exploring the specificity of the PI3K family inhibitor LY294002
10.1042/bj20061489 · 2007 · External reference
Molecular pharmacology of phosphatidylinositol 3-kinase inhibition in human glioma
10.4161/cc.8.3.7643 · 2009 · External reference
