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References from Role of IGF-1 Receptor in Radiation Response. Local targets link to admitted publications; unresolved targets remain external evidence.
Structure and function of the type 1 insulin-like growth factor receptor
10.1007/pl00000744 · 2000 · External reference
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity
10.1002/j.1460-2075.1986.tb04528.x · 1986 · External reference
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade
10.1073/pnas.89.15.6924 · 1992 · External reference
The proto-oncogene Crk-II enhances apoptosis by a Ras-dependent, Raf-1/MAP kinase-independent pathway
10.1006/bbrc.1997.6641 · 1997 · External reference
Cancer treatment strategies targeting sphingolipid metabolism
10.1007/978-1-4419-6741-1_13 · 2010 · External reference
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
10.1126/science.278.5338.687 · 1997 · External reference
Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis
1995 · External reference
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of β1-integrin and phosphatidylinositol 3′-kinase/AKT signaling
2003 · External reference
The type 1 insulin-like growth factor receptor pathway
10.1158/1078-0432.ccr-07-4879 · 2008 · External reference
Annexin II: a mediator of the plasmin/plasminogen activator system
10.1016/s1050-1738(99)00020-1 · 1999 · External reference
Extracellular annexin II is associated with divalent cation-dependent tumor cell-endothelial cell adhesion of metastatic RAW117 large-cell lymphoma cells
10.1002/jcb.240530311 · 1993 · External reference
Secretion of annexin II via activation of insulin receptor and insulin-like growth factor receptor
10.1074/jbc.m210545200 · 2003 · External reference
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene
10.1126/science.3500513 · 1987 · External reference
Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
10.1371/journal.pmed.0020313 · 2005 · External reference
Malignant transformation and EGFR activation of immortalized mouse liver epithelial cells caused by HBV enhancer-X from a human hepatocellular carcinoma
10.1002/(sici)1097-0215(20000215)85:4<518::aid-ijc12>3.0.co;2-7 · 2000 · External reference
A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor
1994 · External reference
Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells
10.1074/jbc.m002915200 · 2000 · External reference
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
2002 · External reference
Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer
1990 · External reference
Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer
1993 · External reference
The prognostic value of insulin-like growth factor-I in breast cancer patients. Results of a follow-up study on 126 patients
10.1016/0959-8049(94)90247-x · 1994 · External reference
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice
10.1002/hep.22194 · 2008 · External reference
Enhancing radiotherapy through a greater understanding of homologous recombination
10.1016/j.semradonc.2010.05.001 · 2010 · External reference
Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways
10.1016/j.mrfmmm.2011.02.005 · 2011 · External reference
Antiapoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after gamma-irradiation
2001 · External reference
Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
1997 · External reference
The insulin-like growth factor I receptor: a key to tumor growth?
1995 · External reference
Differential insulin-like growth factor I receptor signaling and function in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cells
2001 · External reference
Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
10.1038/sj.onc.1204565 · 2001 · External reference
Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors
1992 · External reference
The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo
1995 · External reference
IGF-1R expression in localized cervical carcinoma patients treated by radiochemotherapy
10.1016/j.ygyno.2007.04.004 · 2007 · External reference
Expression and clinical significance of epidermal growth factor receptor and type 1 insulin-like growth factor receptor in nasopharyngeal carcinoma
10.1177/000348940811700306 · 2008 · External reference
Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy
10.1016/j.radonc.2010.03.009 · 2010 · External reference
IGF-1R expression predicts clinical outcome in patients with locally advanced oral squamous cell carcinoma
10.1016/j.oraloncology.2011.05.005 · 2011 · External reference
Low activation of insulin-like growth factor 1-receptor (IGF1R) is associated with local recurrence in early breast carcinoma
10.1007/s10549-008-0139-6 · 2009 · External reference
Clinical implications of insulin-like growth factors through the presence of their binding proteins and receptors expressed in gynecological cancers
2004 · External reference
Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
10.1002/ijc.2910310104 · 1983 · External reference
Clinical evidence for tumor clonogen regeneration: interpretations of the data
10.1016/0167-8140(91)90019-d · 1991 · External reference
Markers of radioresistance in squamous cell carcinomas of the head and neck: a clinicopathologic and immunohistochemical study
10.1200/jco.1997.15.3.1030 · 1997 · External reference
Tumor proliferation, p53 expression, and apoptosis in laryngeal carcinoma: relation to the results of radiotherapy
10.1002/(sici)1097-0142(19981215)83:12<2493::aid-cncr13>3.0.co;2-c · 1998 · External reference
Can Ki67 immunostaining predict response to radiotherapy in oral squamous cell carcinoma?
10.1136/jcp.47.2.109 · 1994 · External reference
The role of Ki67 proliferation assessment in predicting local control in bladder cancer patients treated by radical radiation therapy
10.1016/s0167-8140(98)00033-4 · 1998 · External reference
The decreased influence of overall treatment time on the response of human breast tumor xenografts following prolongation of the potential doubling time (Tpot)
10.1016/0360-3016(94)00540-0 · 1995 · External reference
Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR
2003 · External reference
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
10.1126/science.7792600 · 1995 · External reference
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
10.1073/pnas.98.4.1676 · 2001 · External reference
Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry
10.1083/jcb.112.2.225 · 1991 · External reference
Radiation-induced EGFR-signaling and control of DNA-damage repair
10.1080/09553000701769970 · 2007 · External reference
PARP-1, a determinant of cell survival in response to DNA damage
10.1016/s0301-472x(03)00083-3 · 2003 · External reference
MVP expression is related to IGF1-R in cervical carcinoma patients treated by radiochemotherapy
10.1016/j.ygyno.2008.04.034 · 2008 · External reference
Major vault protein may affect nonhomologous end-joining repair and apoptosis through Ku70/80 and bax downregulation in cervical carcinoma tumors
10.1016/j.ijrobp.2008.11.013 · 2009 · External reference
BCL-2, in combination with MVP and IGF-1R expression, improves prediction of clinical outcome in complete response cervical carcinoma patients treated by radiochemotherapy
10.1016/j.ygyno.2011.05.037 · 2011 · External reference
Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation
10.1073/pnas.0706700105 · 2008 · External reference
Bcl2 negatively regulates DNA double-strand-break repair through a nonhomologous end-joining pathway
10.1016/j.molcel.2007.12.029 · 2008 · External reference
PARP-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells
10.1038/sj.emboj.7601015 · 2006 · External reference
Ionizing radiation activates IGF-1R triggering a cytoprotective signaling by interfering with Ku-DNA binding and by modulating Ku86 expression via a p38 kinase-dependent mechanism
10.1038/sj.onc.1210037 · 2007 · External reference
Genetic blockade of the insulin-like growth factor-I receptor: a promising strategy for human pancreatic cancer
2003 · External reference
Modulation of response to radiation of human lung cancer cells following insulin-like growth factor 1 receptor inactivation
10.1016/j.canlet.2004.10.002 · 2005 · External reference
Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines
10.1016/j.ygyno.2011.01.008 · 2011 · External reference
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
10.1016/j.bmcl.2011.02.075 · 2011 · External reference
Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline
10.1016/j.bmcl.2011.06.090 · 2011 · External reference
The insulin-like growth factor-1 receptor kinase inhibitor, NVP-ADW742, suppresses survival and resistance to chemotherapy in acute myeloid leukemia cells
10.3727/096504010x12828372551821 · 2010 · External reference
Potent and selective cyclohexylderived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy
10.1016/j.bmcl.2010.12.094 · 2011 · External reference
Insulin-like growth factor-I receptor signaling blockade combined with radiation
10.1158/0008-5472.can-06-2000 · 2007 · External reference
Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers
10.1016/j.ijrobp.2010.10.003 · 2011 · External reference
Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells
10.1158/1078-0432.ccr-09-0478 · 2009 · External reference
Lentivirus-mediated RNAi knockdown of insulin-like growth factor-1 receptor inhibits growth, reduces invasion, and enhances radiosensitivity in human osteosarcoma cells
10.1007/s11010-009-0064-y · 2009 · External reference
SiRNA-mediated IGF-1R inhibition sensitizes human colon cancer SW480 cells to radiation
10.3109/02841860903334429 · 2010 · External reference
Dual targeting of IGF-1R and PDGFR inhibits proliferation in high-grade gliomas cells and induces radiosensitivity in JNK-1 expressing cells
10.1007/s11060-007-9417-0 · 2007 · External reference
Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy
10.2174/156800909789271495 · 2009 · External reference
Dual inhibition of epidermal growth factor receptor and insulin-like growth factor receptor I: reduction of angiogenesis and tumor growth in cutaneous squamous cell carcinoma
10.1002/hed.21419 · 2011 · External reference
The insulin-like growth factor system and cancer
10.1016/s0304-3835(03)00159-9 · 2003 · External reference
AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice
10.1158/1078-0432.ccr-04-1665 · 2005 · External reference
Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis
10.1016/j.bbrc.2004.06.175 · 2004 · External reference
Inhibition of insulin-like growth factor I receptor increases the antitumor activity of doxorubicin and vincristine against Ewing's sarcoma cells
2001 · External reference
A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity
10.1074/jbc.m500815200 · 2005 · External reference
ZD1839 (“Iressa”), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model
10.1038/sj.bjc.6600182 · 2002 · External reference