Research graph
References from Antivascular Therapy for Multidrug-Resistant Ovarian Tumors by Macitentan, a Dual Endothelin Receptor Antagonist. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2009
2009 · External reference
Cancer of the ovary
10.1056/nejm199311183292108 · 1993 · External reference
Treatment of relapsed epithelial ovarian cancer
2001 · External reference
AACR Centennial Series: the biology of cancer metastasis: historical perspective
10.1158/0008-5472.can-10-1040 · 2010 · External reference
Biochemistry of multidrug resistance mediated by the multidrug transporter
10.1146/annurev.bi.62.070193.002125 · 1993 · External reference
Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer
10.1093/jnci/djj211 · 2006 · External reference
Macitentan (ACT-064992), a tissue-targeting endothelin receptor antagonist, enhances therapeutic efficacy of paclitaxel by modulating survival pathways in orthotopic models of metastatic human ovarian cancer
10.1593/neo.10806 · 2011 · External reference
Endothelins
10.1056/nejm199508103330607 · 1995 · External reference
Structural organization and chromosomal assignment of the gene encoding endothelin
10.1016/s0021-9258(18)81698-2 · 1989 · External reference
Endothelins in health and disease: an overview
10.1046/j.1440-1681.1999.03014.x · 1999 · External reference
Endothelin receptor antagonism
10.1016/s1054-3589(08)60665-1 · 1995 · External reference
Endothelin receptor antagonists: current status and perspectives
10.1097/00005344-200000002-00015 · 2000 · External reference
Endothelin-1 promotes myofibroblasts induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibro tic fibroblasts
10.1091/mbc.e03-12-0902 · 2004 · External reference
Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade
10.1161/01.cir.100.1.5 · 1999 · External reference
Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice
10.1165/ajrcmb.23.1.4030 · 2000 · External reference
The endothelin axis: emerging role in cancer
10.1038/nrc990 · 2003 · External reference
Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade
10.1158/0008-5472.can-08-1879 · 2009 · External reference
Endothelin-1 is a critical mediator of mitogenic tone in tumor arterioles: implications for cancer treatment
10.1158/0008-5472.can-03-1291 · 2004 · External reference
Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells
10.1158/0008-5472.can-05-2123 · 2005 · External reference
Endothelium-derived factors as paracrine mediators of prostate cancer progression
2000 · External reference
Studies on the expression of endothelin, its receptor subtypes, and converting enzymes in lung cancer and in human bronchial epithelium
10.1165/ajrcmb.22.4.3795 · 2000 · External reference
Increased endothelin-1 in colorectal cancer and reduction of tumour growth by ET(A) receptor antagonism
10.1054/bjoc.2001.2193 · 2001 · External reference
Endothelin-1 promotes cell survival in renal cell carcinoma through the ET(A) receptor
10.1016/j.canlet.2006.02.007 · 2007 · External reference
Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade
2002 · External reference
The endothelin system in human glioblastoma
10.1038/labinvest.3780178 · 2000 · External reference
ZD4054, a specific antagonist of the endothelin A receptor, inhibits tumor growth and enhances paclitaxel activity in human ovarian carcinoma in vitro and in vivo
10.1158/1535-7163.mct-07-0151 · 2007 · External reference
Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells
10.1158/0008-5472.can-08-2093 · 2008 · External reference
β-Arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis
10.1073/pnas.0807158106 · 2009 · External reference
Role of the endothelin axis and its antagonists in the treatment of cancer
10.1111/j.1476-5381.2011.01217.x · 2011 · External reference
Pharmacology of macitentan, an orally active tissue targeting dual endothelin receptor antagonist
10.1124/jpet.108.142976 · 2008 · External reference
The pathogenesis of cancer metastasis: the “seed and soil” hypothesis revisited (Timeline)
10.1038/nrc1098 · 2003 · External reference
Antivascular therapy for orthotopic human ovarian carcinoma through blockade of the vascular endothelial growth factor and epidermal growth factor receptors
10.1158/1078-0432.ccr-04-2060 · 2005 · External reference
Combination drug delivery strategy for the treatment of multidrug resistant ovarian cancer
10.1021/mp100323z · 2011 · External reference
Ovarian cancer: strategies for overcoming resistance to chemotherapy
10.1038/nrc1123 · 2003 · External reference
Mechanisms of resistance to cisplatin and carboplatin
10.1016/j.critrevonc.2007.02.001 · 2007 · External reference
Regulators of G-protein signaling RGS10 and RGS17 regulate chemoresistance in ovarian cancer cells
10.1186/1476-4598-9-289 · 2010 · External reference
Endothelin-1 and transforming growth factor-β1 independently induce fibroblast resistance to apoptosis via AKT activation
10.1165/rcmb.2008-0447oc · 2009 · External reference
Endothelin receptor blockade potentiates FasL-induced apoptosis in colon carcinoma cells via the protein kinase C pathway
10.1097/00005344-200036051-00103 · 2000 · External reference
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells
2000 · External reference
Endothelin receptor A blockade enhances taxane effects in prostate cancer
10.1593/neo.06388 · 2006 · External reference
Modulation of the organ microenvironment for the treatment of cancer metastasis
10.1093/jnci/87.21.1588 · 1995 · External reference
