Research graph
References from CXCR4 Expression and Treatment with SDF-1α or Plerixafor Modulate Proliferation and Chemosensitivity of Colon Cancer Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Colorectal carcinoma: diagnostic prognostic and molecular features
10.1097/01.mp.0000062859.46942.93 · 2003 · External reference
10.1093/annonc/mdm379
10.1093/annonc/mdm379 · 2007 · External reference
Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study
10.1200/jco.2007.11.3357 · 2007 · External reference
New insights on the role of CXCR4 in cancer metastasis
10.1002/path.2350 · 2008 · External reference
Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival
10.1200/jco.2005.07.078 · 2005 · External reference
Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer
10.1158/1078-0432.ccr-04-1195 · 2005 · External reference
The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood
10.1084/jem.185.1.111 · 1997 · External reference
Involvement of chemokine receptors in breast cancer metastasis
10.1038/35065016 · 2001 · External reference
Organ selectivity in metastasis: regulation by chemokines and their receptors
10.1007/s10585-007-9097-3 · 2008 · External reference
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis
10.1634/stemcells.2004-0342 · 2005 · External reference
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
10.1016/j.cell.2005.02.034 · 2005 · External reference
Stromal fibroblasts in cancer: a novel tumor-promoting cell type
10.4161/cc.5.15.3112 · 2006 · External reference
Vascular endothelial growth factor secreted by activated stroma enhances angiogenesis and hormone-independent growth of estrogen receptor-positive breast cancer
10.1158/0008-5472.can-09-4373 · 2010 · External reference
Metastatic breast cancer cells in the bone marrow microenvironment: novel insights into oncoprotection
10.1007/s12156-010-0071-y · 2011 · External reference
Dissecting the metastatic cascade
10.1038/nrc1370 · 2004 · External reference
Dissemination and growth of cancer cells in metastatic sites
10.1038/nrc865 · 2002 · External reference
Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients
10.1006/scbi.2001.0386 · 2001 · External reference
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
10.1182/blood-2005-08-3182 · 2006 · External reference
Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
10.1097/01.qai.0000137371.80695.ef · 2004 · External reference
Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers
10.1128/aac.44.6.1667-1673.2000 · 2000 · External reference
Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
10.1182/blood-2003-02-0663 · 2003 · External reference
CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers
10.1038/leu.2008.299 · 2009 · External reference
A lentiviral CXCR4 overexpression and knockdown model in colorectal cancer cell lines reveals Plerixafor-dependent suppression of SDF-1α-induced migration and invasion
2011 · External reference
The AMD3100 story: the path to the discovery of a stem cell mobilizer (Mozobil)
10.1016/j.bcp.2008.12.014 · 2009 · External reference
Stroma-conditioned media improve expansion of human primitive hematopoietic stem cells and progenitor cells
10.1038/sj.leu.2400530 · 1997 · External reference
High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
10.1089/10430340252898984 · 2002 · External reference
Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer
10.1158/1541-7786.mcr-09-0326 · 2010 · External reference
Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O6-methylguanine-DNA methyltransferaseP140K
10.1038/gt.2009.133 · 2010 · External reference
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
10.1016/0065-2571(84)90007-4 · 1984 · External reference
Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib
10.1080/10428190903150847 · 2009 · External reference
The α-chemokine, stromal cell-derived factor-1α, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways
10.1074/jbc.273.36.23169 · 1998 · External reference
CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation
10.1016/j.yexcr.2005.07.006 · 2005 · External reference
AMD3100 is a CXCR7 ligand with allosteric agonist properties
10.1124/mol.108.053389 · 2009 · External reference
Stromal fibroblasts in cancer initiation and progression
10.1038/nature03096 · 2004 · External reference
Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines
10.1182/blood.v93.5.1658 · 1999 · External reference
Tumor microenvironment and drug resistance in hematologic malignancies
10.1016/j.blre.2005.08.003 · 2006 · External reference
Targeting leukemic stem cells by breaking their dormancy
10.1016/j.molonc.2010.06.001 · 2010 · External reference
The significance of cancer cell expression of the chemokine receptor CXCR4
10.1016/j.semcancer.2003.10.003 · 2004 · External reference
Influence of CXCR4/SDF-1 axis on E-cadherin/β-catenin complex expression in HT29 colon cancer cells
10.3748/wjg.v17.i5.625 · 2011 · External reference
The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases
2003 · External reference
Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis
10.1593/neo.07559 · 2007 · External reference
CXCR4 regulates the early extravasation of metastatic tumor cells in vivo
10.1593/neo.09272 · 2009 · External reference
Chemokines
10.1182/blood.v90.3.909 · 1997 · External reference
The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2mnull mice
10.1038/sj.leu.2402684 · 2002 · External reference
The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia—CXCR4 antagonists as potential adjuvants for monoclonal antibodies
10.1111/j.1365-2141.2010.08316.x · 2010 · External reference
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
10.1182/blood-2008-10-186668 · 2009 · External reference
17β-Estradiol promotes breast cancer cell proliferation-inducing stromal cell-derived factor-1-mediated epidermal growth factor receptor transactivation: reversal by gefitinib pretreatment
10.1124/mol.107.039974 · 2008 · External reference
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti-EGFR treatment in colorectal cancer: a cohort study
10.1016/s1470-2045(05)70102-9 · 2005 · External reference
