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References from Endoplasmic Reticulum Stress Plays a Pivotal Role in Cell Death Mediated by the Pan-Deacetylase Inhibitor Panobinostat in Human Hepatocellular Cancer Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Cell death and hepatocarcinogenesis: dysregulation of apoptosis signaling pathways
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Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
10.1186/1756-8722-3-5 · 2010 · External reference
Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges
10.1016/j.canlet.2009.02.019 · 2009 · External reference
New drugs, old fashioned ways: ER stress induced cell death
10.2174/138920112802501962 · 2011 · External reference
Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells
10.1158/1535-7163.mct-09-0988 · 2010 · External reference
Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stressmediated apoptosis in oral squamous cell carcinoma cells
10.1007/s00280-009-0969-x · 2009 · External reference
Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat
10.1593/neo.91422 · 2010 · External reference
Combination of the deacetylase inhibitor panobinostat and the multi-kinase inhibitor sorafenib for the treatment of metastatic hepatocellular carcinoma-review of the underlying molecular mechanisms and first case report
10.7150/jca.4211 · 2012 · External reference
Novel therapeutics in multiple myeloma
10.1179/102453312x13336169156131 · 2012 · External reference
The pandeacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis
2010 · External reference
The unfolded protein response: from stress pathway to homeostatic regulation
10.1126/science.1209038 · 2011 · External reference
Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis
10.1111/j.1349-7006.2006.00235.x · 2006 · External reference
Signal integration in the endoplasmic reticulum unfolded protein response
10.1038/nrm2199 · 2007 · External reference
Fine-tuning of the unfolded protein response: assembling the IRE1α interactome
10.1016/j.molcel.2009.08.021 · 2009 · External reference
Endoplasmic reticulum stress in liver disease
10.1016/j.jhep.2010.11.005 · 2011 · External reference
A trip to the ER: coping with stress
10.1016/j.tcb.2003.11.001 · 2004 · External reference
Stress management at the ER: regulators of ER stress-induced apoptosis
10.1016/j.pharmthera.2012.02.003 · 2012 · External reference
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
10.1038/ncb0311-184 · 2011 · External reference
Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases
10.1111/j.1463-1326.2010.01282.x · 2010 · External reference
Downregulation of HMGA2 by the pandeacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines
10.1016/j.yexcr.2012.04.018 · 2012 · External reference
Quantitative immunohistochemistry of fluorescence labelled probes using low-cost software
10.1016/j.jim.2005.04.006 · 2005 · External reference
Use of ferrocyanide reduced osmium in electron microscopy
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Measurement of section thickness
1968 · External reference
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10.1083/jcb.4.3.233 · 1958 · External reference
Roles of CHOP/GADD153 in endoplasmic reticulum stress
10.1038/sj.cdd.4401373 · 2004 · External reference
Unconventional splicing of XBP-1 mRNA in the unfolded protein response
10.1089/ars.2007.1800 · 2007 · External reference
Extensive immunoglobulin production sensitizes myeloma cells for proteasome inhibition
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Improved chemotherapy for hepatocellular carcinoma
2012 · External reference
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Histone deacetylase inhibitors for treatment of hepatocellular carcinoma
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10.1038/icb.2011.100 · 2012 · External reference
Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors
2011 · External reference
Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors
10.2217/fon.09.36 · 2009 · External reference
Histone deacetylase inhibitors: signalling towards p21cip1/waf1
10.1016/j.biocel.2007.03.001 · 2007 · External reference
Deacetylase inhibitors-focus on non-histone targets and effects
10.4331/wjbc.v1.i5.55 · 2010 · External reference
Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells
10.1158/1535-7163.mct-11-0979 · 2012 · External reference
Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma
10.4161/auto.6.8.13365 · 2010 · External reference
ER chaperones in mammalian development and human diseases
10.1016/j.febslet.2007.04.045 · 2007 · External reference
GRP78 induction in cancer: therapeutic and prognostic implications
10.1158/0008-5472.can-07-0325 · 2007 · External reference
ER stress inducer, thapsigargin, decreases extracellular-superoxide dismutase through MEK/ERK signalling cascades in COS7 cells
10.3109/10715762.2011.567985 · 2011 · External reference
Intersection of the unfolded protein response and hepatic lipid metabolism
10.1007/s00018-009-0049-8 · 2009 · External reference
Sensing endoplasmic reticulum stress
10.1007/978-1-4614-1680-7_10 · 2012 · External reference
XBP1 controls diverse cell type- and conditionspecific transcriptional regulatory networks
10.1016/j.molcel.2007.06.011 · 2007 · External reference
Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response
10.1038/sj.cdd.4402154 · 2007 · External reference
A review of the mammalian unfolded protein response
10.1002/bit.23282 · 2011 · External reference
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
10.1038/nrm3270 · 2012 · External reference
Pathophysiological roles of ASK1-MAP kinase signaling pathways
2007 · External reference
Caspase-12 and ER-stressmediated apoptosis: the story so far
10.1196/annals.1299.032 · 2003 · External reference
ER stress and apoptosis: a new mechanism for retinal cell death
10.1155/2012/589589 · 2012 · External reference
Caspases involved in ER stress- mediated cell death
10.1016/j.jchemneu.2004.05.008 · 2004 · External reference
Caspases in cell survival, proliferation and differentiation
10.1038/sj.cdd.4402047 · 2007 · External reference
In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis C
10.1002/path.2703 · 2010 · External reference
PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1α signaling and endoplasmic reticulum stress
10.1242/dev.028118 · 2008 · External reference
Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients
10.1016/j.nbd.2010.12.005 · 2011 · External reference
Scotin: a new p63 target gene expressed during epidermal differentiation
10.1016/j.bbrc.2007.12.115 · 2008 · External reference
p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis
10.1016/j.devcel.2011.07.012 · 2011 · External reference
Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes
10.4049/jimmunol.1001822 · 2011 · External reference
Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis
2012 · External reference
Stress-induced selfcannibalism: on the regulation of autophagy by endoplasmic reticulum stress
2012 · External reference
Modulating stress responses by the UPRosome: a matter of life and death
10.1016/j.tibs.2011.03.001 · 2011 · External reference
DAPK plays an important role in panobinostat-induced autophagy and commits cells to apoptosis under autophagy deficient conditions
10.1007/s10495-012-0757-7 · 2012 · External reference
The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes
10.1074/jbc.m111.304956 · 2011 · External reference
A CHOP-regulated micro- RNA controls rhodopsin expression
10.1083/jcb.201010055 · 2011 · External reference
ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer
10.1371/journal.pone.0031518 · 2012 · External reference
Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia
10.1182/blood-2011-05-351510 · 2012 · External reference
The histone deacetylase inhibitor trichostatin A alters microRNA expression profiles in apoptosis-resistant breast cancer cells
2012 · External reference
Suberoylanilide hydroxamic acid (SAHA) changes micro- RNA expression profiles in A549 human non-small cell lung cancer cells
2009 · External reference
Downregulation of HMGA2 by the pandeacetylase inhibitor panobinostat is dependent on hsa-let-7b expression in liver cancer cell lines
10.1016/j.yexcr.2012.04.018 · 2012 · External reference
The pan-deacetylase inhibitor panobinostat inhibits growth of hepatocellular carcinoma models by alternative pathways of apoptosis
2010 · External reference
