Research graph
References from GL3, a Novel 4β-Anilino-4′-O-Demethyl-4-Desoxypodophyllotoxin Analog, Traps Topoisomerase II Cleavage Complexes and Exerts Anticancer Activities. Local targets link to admitted publications; unresolved targets remain external evidence.
Cellular roles of DNA topoisomerases: a molecular perspective
10.1038/nrm831 · 2002 · External reference
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs
10.1016/j.chembiol.2010.04.012 · 2010 · External reference
DNA topoisomerase poisons as antitumor drugs
10.1146/annurev.bi.58.070189.002031 · 1989 · External reference
Catalytic inhibitors of DNA topoisomerase II
10.1016/s0167-4781(98)00133-x · 1998 · External reference
Cellular response to etoposide treatment
10.1016/j.canlet.2006.11.005 · 2007 · External reference
Etoposide: four decades of development of a topoisomerase II inhibitor
10.1016/s0959-8049(98)00228-7 · 1998 · External reference
Etoposide, topoisomerase II and cancer
10.2174/1568011054222364 · 2005 · External reference
Synthesis and biological evaluation of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents
10.1016/j.ejmech.2010.11.016 · 2011 · External reference
R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II
10.1158/1535-7163.mct-06-0584 · 2007 · External reference
Potent antitumor activity of 10-methoxy-9-nitrocamptothecin
10.1158/1535-7163.mct-05-0385 · 2006 · External reference
F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system
10.1158/0008-5472.can-08-2748 · 2008 · External reference
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage
10.1021/bi200094z · 2011 · External reference
5k, a novel β-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis
10.1007/s10637-010-9423-5 · 2011 · External reference
Catalytic topoisomerase II inhibitors in cancer therapy
10.1016/s0163-7258(03)00058-5 · 2003 · External reference
DNA topoisomerase II rescue by catalytic inhibitors: a new strategy to improve the antitumor selectivity of etoposide
10.1016/s0006-2952(97)00116-0 · 1997 · External reference
ICRF-187 (dexrazoxan) protects from adriamycin-induced nephrotic syndrome in rats
10.1093/ndt/13.8.1975 · 1998 · External reference
Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines
1998 · External reference
Maleimide is a potent inhibitor of topoisomerase II in vitro and in vivo: a new mode of catalytic inhibition
10.1016/s0026-895x(24)12220-1 · 2002 · External reference
Tirapazamine: a hypoxia-activated topoisomerase II poison
2002 · External reference
Antagonistic effect of aclarubicin on the cytotoxicity of etoposide and 4′-(9-acridinylamino)methanesulfon-m-anisidide in human small cell lung cancer cell lines and on topoisomerase II-mediated DNA cleavage
1990 · External reference
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II
1991 · External reference
