Research graph
References from 2-Hydroxyglutarate as a Magnetic Resonance Biomarker for Glioma Subtyping. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
10.1038/nature08617 · 2009 · External reference
Unresolved reference
External reference
IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas
10.2353/ajpath.2009.080958 · 2009 · External reference
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
10.1007/s00401-009-0561-9 · 2009 · External reference
An integrated genomic analysis of human glioblastoma multiforme
10.1126/science.1164382 · 2008 · External reference
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
10.1016/j.ccr.2010.11.015 · 2010 · External reference
Analysis of the IDH1 codon 132 mutation in brain tumors
10.1007/s00401-008-0455-2 · 2008 · External reference
IDH1 and IDH2 mutations in gliomas
10.1056/nejmoa0808710 · 2009 · External reference
Genetic pathways to primary and secondary glioblastoma
10.2353/ajpath.2007.070011 · 2007 · External reference
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
10.1158/1078-0432.ccr-09-0715 · 2009 · External reference
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
10.1073/pnas.1019393108 · 2011 · External reference
Metabolic profiles of cancer cells
10.1038/nrc1390 · 2004 · External reference
Magnetic resonance spectroscopy of cancer metabolism and response to therapy
10.1667/rr2903.1 · 2012 · External reference
2-Hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
10.1038/nm.2682 · 2012 · External reference
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
10.1126/scitranslmed.3002693 · 2012 · External reference
Unresolved reference
2000 · External reference
Nuclear magnetic resonance spectra from a crystal rotated at high speed
10.1038/1821659a0 · 1958 · External reference
High-resolution magic angle spinning MRS of breast cancer tissue
10.1002/nbm.775 · 2002 · External reference
MR-determined metabolic phenotype of breast cancer in prediction of lymphatic spread, grade, and hormone status
10.1007/s10549-006-9400-z · 2007 · External reference
Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens
1998 · External reference
Predicting long-term survival and treatment response in breast cancer patients receiving neoadjuvant chemotherapy by MR metabolic profiling
10.1002/nbm.1762 · 2012 · External reference
HR MAS MR spectroscopy in metabolic characterization of cancer
10.2174/156802611793611869 · 2011 · External reference
Magnetic resonance metabolomics of intact tissue: a biotechnological tool in cancer diagnostics and treatment evaluation
10.1158/0008-5472.can-10-0437 · 2010 · External reference
Lactate and glycine—potential MR biomarkers of prognosis in estrogen receptor-positive breast cancers
10.1002/nbm.2798 · 2012 · External reference
Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy
10.1002/mrm.21647 · 2008 · External reference
Cancer-associated IDH mutations: biomarker and therapeutic opportunities
10.1038/onc.2010.444 · 2010 · External reference
Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
10.1126/scitranslmed.3002796 · 2012 · External reference
Detection of “oncometabolite” 2-hydroxyglutarate by magnetic resonance analysis as a biomarker of IDH1/2 mutations in glioma
10.1007/s00109-012-0888-x · 2012 · External reference
Sterilization by means of ethylene oxide
1975 · External reference
Spatial localization in NMR spectroscopy in vivo
10.1111/j.1749-6632.1987.tb32915.x · 1987 · External reference
Low-power adiabatic sequences for in vivo localized two-dimensional chemical shift correlated MR spectroscopy
10.1002/mrm.22535 · 2010 · External reference
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
10.1007/s11060-011-0737-8 · 2012 · External reference
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
10.1002/mrm.1910300604 · 1993 · External reference
An in vivo patient-derived model of endogenous IDH1-mutant glioma
10.1093/neuonc/nor207 · 2012 · External reference
Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors
10.1111/j.1750-3639.2009.00352.x · 2010 · External reference
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
10.1215/15228517-2009-025 · 2009 · External reference
IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
10.1158/1078-0432.ccr-09-2902 · 2010 · External reference
Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network
10.1200/jco.2009.23.0805 · 2009 · External reference
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo
10.1002/ana.22390 · 2011 · External reference