Research graph
References from Notch Pathway Is Activated by MAPK Signaling and Influences Papillary Thyroid Cancer Proliferation. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2010
2010 · External reference
Increasing incidence of thyroid cancer in the United States, 1973–2002
10.1001/jama.295.18.2164 · 2006 · External reference
Unresolved reference
2004 · External reference
Mini-review: RET: normal and abnormal functions
10.1210/en.2004-0922 · 2004 · External reference
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
2003 · External reference
Molecular diagnostics and predictors in thyroid cancer
10.1089/thy.2009.0240 · 2009 · External reference
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis
10.1210/mend-4-10-1474 · 1990 · External reference
The RET proto-oncogene in human cancers
10.1038/sj.onc.1203857 · 2000 · External reference
Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation
10.1172/jci46382 · 2011 · External reference
The canonical Notch signaling pathway: unfolding the activation mechanism
10.1016/j.cell.2009.03.045 · 2009 · External reference
Notch signaling: cell fate control and signal integration in development
10.1126/science.284.5415.770 · 1999 · External reference
HES and HERP families: multiple effectors of the Notch signaling pathway
10.1002/jcp.10208 · 2003 · External reference
Notch and Schwann cell transformation
10.1038/sj.onc.1207068 · 2004 · External reference
Active Notch1 confers a transformed phenotype to primary human melanocytes
10.1158/0008-5472.can-08-3767 · 2009 · External reference
Aberrant activation of notch signaling in human breast cancer
10.1158/0008-5472.can-05-3054 · 2006 · External reference
Notch1 is an effector of Akt and hypoxia in melanoma development
10.1172/jci36157 · 2008 · External reference
Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomas
10.1593/neo.08356 · 2008 · External reference
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
10.1126/science.1102160 · 2004 · External reference
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
10.1038/nrc1186 · 2003 · External reference
Notch signalling in solid tumours: a little bit of everything but not all the time
10.1038/nrc3035 · 2011 · External reference
Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion
10.1073/pnas.0610733104 · 2007 · External reference
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
10.1038/nm754 · 2002 · External reference
Conditional expression of RET/PTC induces a weak oncogenic drive in thyroid PCCL3 cells and inhibits thyrotropin action at multiple levels
10.1210/me.2003-0041 · 2003 · External reference
Effects of let-7 microRNA on cell growth and differentiation of papillary thyroid cancer
10.1593/tlo.09151 · 2009 · External reference
A new mathematical model for relative quantification in real-time RT-PCR
10.1093/nar/29.9.e45 · 2001 · External reference
Expression of SMAD proteins, TGF-beta/activin signaling mediators, in human thyroid tissues
10.1590/s0004-27302010000400010 · 2010 · External reference
MicroRNA miR-146b-5p regulates signal transduction of TGF-β by repressing SMAD4 in thyroid cancer
10.1038/onc.2011.381 · 2011 · External reference
Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
10.1158/0008-5472.can-05-0047 · 2005 · External reference
Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
10.1016/s1535-6108(03)00140-5 · 2003 · External reference
Notch signaling is involved in expression of thyrocyte differentiation markers and is down-regulated in thyroid tumors
10.1210/jc.2008-0528 · 2008 · External reference
Delta-like 4/Notch pathway is differentially regulated in benign and malignant thyroid tissues
10.1089/thy.2010.0444 · 2011 · External reference
Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
10.1016/j.ccr.2005.06.004 · 2005 · External reference
Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK
10.1016/j.ccr.2012.06.014 · 2012 · External reference
Conditional activation of RET/ PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling
10.1158/0008-5472.can-06-0739 · 2006 · External reference
Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer
10.1038/sj.onc.1207980 · 2004 · External reference
RET/PTC1-driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation
10.1593/neo.08916 · 2009 · External reference
BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor κB activation
10.1210/en.2006-0400 · 2006 · External reference
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
10.1073/pnas.0606108103 · 2006 · External reference
Notch-dependent cell cycle arrest is associated with downregulation of minichromosome maintenance proteins
10.1161/01.res.0000174380.06673.81 · 2005 · External reference
Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1
10.1158/0008-5472.can-06-0974 · 2006 · External reference
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
10.1101/gad.341405 · 2005 · External reference
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1
10.1128/mcb.25.10.4262-4271.2005 · 2005 · External reference
JAGGED1 expression is associated with prostate cancer metastasis and recurrence
10.1158/0008-5472.can-04-2500 · 2004 · External reference
Notch1 receptor as a marker of lymph node metastases in papillary thyroid cancer
10.1111/j.1349-7006.2011.02161.x · 2011 · External reference
Rational targeting of Notch signaling in cancer
10.1038/onc.2008.226 · 2008 · External reference
High level of Notch1 protein is associated with poor overall survival in colorectal cancer
10.1245/s10434-009-0893-7 · 2010 · External reference
