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References from CXCR2 Macromolecular Complex in Pancreatic Cancer: A Potential Therapeutic Target in Tumor Growth. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2012
2012 · External reference
Molecular targeted approaches for treatment of pancreatic cancer
10.2174/138161211796957427 · 2011 · External reference
Tumor microenvironment and pancreatic cancer
2012 · External reference
Chemokines and chemokine receptors in leukocyte trafficking
10.1152/ajpregu.00738.2001 · 2002 · External reference
Transcriptional anti-angiogenesis therapy of human pancreatic cancer
10.1016/j.cytogfr.2006.01.002 · 2006 · External reference
NF-κB activity blockade impairs the angiogenic potential of human pancreatic cancer cells
10.1002/ijc.11562 · 2004 · External reference
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic
1999 · External reference
Understanding the role of cytokines in glioblastoma multiforme pathogenesis
10.1016/j.canlet.2011.11.001 · 2012 · External reference
The interleukin-8 pathway in cancer
10.1158/1078-0432.ccr-07-4843 · 2008 · External reference
The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours
10.1016/j.cyto.2009.11.010 · 2010 · External reference
Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer
10.1016/j.ajpath.2010.11.058 · 2011 · External reference
Autocrine growth effect of IL-8 and GROalpha on a human pancreatic cancer cell line, Capan-1
10.1097/00006676-200007000-00051 · 2000 · External reference
Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface: impact on human pancreatic carcinoma cell growth by autocrine regulation.
10.1002/cncr.10812 · 2002 · External reference
Potential involvement of IL-8 and its receptors in the invasiveness of pancreatic cancer cells
2003 · External reference
Effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells
10.1007/s002620050503 · 1998 · External reference
Enhanced ENA-78 and IL-8 expression in patients with malignant pancreatic diseases
10.1159/000151776 · 2008 · External reference
Identification of critical regions on phospholipase C-β1 required for activation by G-proteins
10.1016/s0021-9258(18)53750-9 · 1993 · External reference
PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane
10.1172/jci6509 · 1999 · External reference
CFTR chloride channel in the apical compartments: spatiotemporal coupling to its interacting partners
10.1039/b924455g · 2010 · External reference
A macromolecular complex of β2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA
10.1073/pnas.0135434100 · 2003 · External reference
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions
10.1084/jem.20050421 · 2005 · External reference
Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia
10.1016/j.cell.2007.09.037 · 2007 · External reference
Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer
10.1016/j.canlet.2009.12.009 · 2010 · External reference
In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes
2012 · External reference
The interaction of phospholipase C-β3 with Shank2 regulates mGluR-mediated calcium signal
10.1074/jbc.m410740200 · 2005 · External reference
Subtype-specific role of phospholipase C-β in bradykinin and LPA signaling through differential binding of different PDZ scaffold proteins.
10.1016/j.cellsig.2010.03.010 · 2010 · External reference
Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles
10.1152/physiolgenomics.00001.2010 · 2010 · External reference
Regulation of phospholipase C-β3 activity by Na+/H+ exchanger regulatory factor 2
10.1074/jbc.m001410200 · 2000 · External reference
Breakthroughs and views—the roles of PDZ-containing proteins in PLC-beta-mediated signaling
10.1006/bbrc.2001.5710 · 2001 · External reference
A chemokine receptor CXCR2 macro-molecular complex regulates neutrophil functions in inflammatory diseases
10.1074/jbc.m111.315762 · 2012 · External reference
The carboxyl-terminal PDZ ligand motif of chemokine receptor CXCR2 modulates post-endocytic sorting and cellular chemotaxis
10.1074/jbc.m804054200 · 2008 · External reference
Phospholipase C-β3 and -β1 form homodimers, but not heterodimers, through catalytic and carboxyl-terminal domains
10.1124/mol.105.021923 · 2006 · External reference
Broad-spectrum G protein-coupled receptor antagonist, [D-Arg1,D-Trp5,7,9,Leu11]SP: a dual inhibitor of growth and angiogenesis in pancreatic cancer
10.1158/0008-5472.can-04-3197 · 2005 · External reference
CXC-chemokine/ CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer
10.1002/ijc.24383 · 2009 · External reference
CXCL8/IL-8 and CXCL12/SDF-1α cooperatively promote invasiveness and angiogenesis in pancreatic cancer
10.1002/ijc.24040 · 2009 · External reference
Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis
10.1016/j.canlet.2005.10.041 · 2006 · External reference
CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination
10.1371/journal.pone.0011340 · 2010 · External reference
Met receptor tyrosine kinase signaling induces secretion of the angiogenic chemokine interleukin-8/CXCL8 in pancreatic cancer
10.1371/journal.pone.0040420 · 2012 · External reference
Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer
10.1111/j.1349-7006.2008.00740.x · 2008 · External reference
TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche
10.1158/0008-5472.can-08-1748 · 2008 · External reference
Subtype-specific roles of phospholipase C-β via differential interactions with PDZ domain proteins
10.1016/j.advenzreg.2010.10.004 · 2011 · External reference
The role of carboxyl-terminal basic amino acids in Gqα-dependent, activation, particulate association, and nuclear localization of phospholipase C-β1
10.1074/jbc.271.35.21187 · 1996 · External reference
Regulation of phosphoinositide-specific phospholipase C
10.1146/annurev.biochem.70.1.281 · 2001 · External reference
Regulation of phospholipase C-beta 4 by ribonucleotides and the alpha subunit of Gq
10.1016/s0021-9258(18)47252-3 · 1994 · External reference
A β2 adrenergic receptor signaling complex assembled with the Ca2+ channel Cav1.2
10.1126/science.293.5527.98 · 2001 · External reference