Research graph
References from The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs. Local targets link to admitted publications; unresolved targets remain external evidence.
Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors
1999 · External reference
Unresolved reference
1992 · External reference
Effect of antigen turnover rate and expression level on antibody penetration into tumor spheroids
10.1158/1535-7163.mct-08-0067 · 2008 · External reference
Intermittent blood flow in a murine tumor: radiobiological effects
1987 · External reference
High interstitial fluid pressure—an obstacle in cancer therapy
10.1038/nrc1456 · 2004 · External reference
Barriers to drug delivery in solid tumors
10.1038/scientificamerican0794-58 · 1994 · External reference
Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier
10.1073/pnas.92.19.8999 · 1995 · External reference
Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab′)2, and Fab in tumors
1989 · External reference
From whole monoclonal antibodies to single domain antibodies: think small
10.1007/978-1-61779-968-6_1 · 2012 · External reference
Antibody engineering for the development of therapeutic antibodies
10.1016/s1016-8478(23)25245-0 · 2005 · External reference
Drug penetration in solid tumours
10.1038/nrc1893 · 2006 · External reference
Theoretic criteria for antibody penetration into solid tumors and micrometastases
10.2967/jnumed.106.037069 · 2007 · External reference
Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu
10.1038/bjc.1998.233 · 1998 · External reference
High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules
2001 · External reference
10.4161/mabs.2.1.10786 · 2010 · Admitted local publication
Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms
1992 · External reference
Targeting of bivalent anti-ErbB2 diabody antibody fragments to tumor cells is independent of the intrinsic antibody affinity
2000 · External reference
Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size
10.1158/0008-5472.can-09-2724 · 2010 · External reference
Avidity-mediated enhancement of in vivo tumor targeting by single-chain Fv dimers
10.1158/1078-0432.ccr-05-2217 · 2006 · External reference
Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth
10.1158/1078-0432.ccr-10-2317 · 2011 · External reference
The effect of antibody protein dose on the uniformity of tumor distribution of radioantibodies: an autoradiographic study
10.1007/bf01741594 · 1991 · External reference
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy
10.1016/s0022-2836(03)00992-6 · 2003 · External reference
Chemical generation of bispecific antibodies
10.1073/pnas.1016478108 · 2010 · External reference
Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention
10.1016/j.jhep.2008.08.015 · 2009 · External reference
Influence of affinity and antigen internalization on the uptake and penetration of anti-HER2 antibodies in solid tumors
10.1158/0008-5472.can-10-2277 · 2011 · External reference
Liver-specific activities of FGF19 require Klotho beta
10.1074/jbc.m704244200 · 2007 · External reference
Sp1-mediated transcriptional control of fibroblast growth factor receptor 4 in sarcomas of skeletal muscle lineage
10.1158/1078-0432.ccr-04-0223 · 2004 · External reference
The strength of small: improved targeting of insulin-like growth factor-1 receptor (IGF-1R) with F(ab′)-R1507 fragments in Ewing sarcomas
2013 · External reference
A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio
2012 · External reference
Practical theoretic guidance for the design of tumor-targeting agents
10.1016/b978-0-12-396962-0.00010-0 · 2012 · External reference
Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo
10.1158/0008-5472.can-05-1093 · 2005 · External reference
Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
10.1158/0008-5472.can-05-4199 · 2006 · External reference
Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts
1988 · External reference
Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
1988 · External reference
Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies
10.1158/1535-7163.mct-11-1038 · 2012 · External reference
The fate of antibodies bound to the surface of tumor cells in vitro
1992 · External reference
Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking
10.1126/science.7516582 · 1994 · External reference
FGF19 and cancer
10.1007/978-1-4614-0887-1_12 · 2012 · External reference
