Research graph
References from Metronomic Chemotherapy: Possible Clinical Application in Advanced Hepatocellular Carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Liver cancer: an evolving challenge reaching research maturity
10.1002/hep.22259 · 2008 · External reference
The anti-angiogenic basis of metronomic chemotherapy
10.1038/nrc1369 · 2004 · External reference
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
10.1056/nejmoa011954 · 2002 · External reference
The verdict is not in yet. Analysis of the randomized trials of high-dose chemotherapy for breast cancer
2003 · External reference
High-dose chemotherapy for breast cancer: the French PEGASE experience
10.1177/107327480301000105 · 2003 · External reference
Repopulation of cancer cells during therapy: an important cause of treatment failure
10.1038/nrc1650 · 2005 · External reference
Tumor angiogenesis: therapeutic implications
10.1056/nejm197111182852108 · 1971 · External reference
What is the evidence that tumors are angiogenesis dependent?
10.1093/jnci/82.1.4 · 1990 · External reference
The implications of angiogenesis for the biology and therapy of cancer metastasis
10.1016/0092-8674(94)90187-2 · 1994 · External reference
Orthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study
10.1038/sj.bjc.6600318 · 2002 · External reference
Vascular endothelial-targeted therapy combined with cytotoxic chemotherapy induces inflammatory intratumoral infiltrates and inhibits tumor relapses after surgery
10.1593/neo.12208 · 2012 · External reference
Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
10.1002/bies.950130106 · 1991 · External reference
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
10.1172/jci8829 · 2000 · External reference
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
2000 · External reference
Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
10.1172/jci9872 · 2000 · External reference
Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity
10.1182/blood-2005-04-1422 · 2005 · External reference
10.1593/tlo.11124 · 2011 · Admitted local publication
Cancer survival in Africa, Asia, the Caribbean and Central America: database and attributes
2011 · External reference
Has the time come for metronomics in low-income and middle-income countries?
10.1016/s1470-2045(13)70056-1 · 2013 · External reference
Global cancer statistics
2011 · External reference
Estimating the world cancer burden: Globocan 2000
10.1002/ijc.1440 · 2001 · External reference
Benign and malignant nodules in cirrhotic livers: distinction based on blood supply
10.1148/radiology.178.2.1846240 · 1991 · External reference
Vascular changes in hepatocellular carcinoma: correlation of radiologic and pathologic findings
10.2214/ajr.173.5.10541091 · 1999 · External reference
Vascular changes in hepatocellular carcinoma
10.1002/ar.20668 · 2008 · External reference
Management of hepatocellular carcinoma
10.1002/hep.20933 · 2005 · External reference
Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection
10.1053/j.gastro.2010.12.032 · 2011 · External reference
Sorafenib in advanced hepatocellular carcinoma
10.1056/nejmoa0708857 · 2008 · External reference
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, doubleblind, placebo-controlled trial
10.1016/s1470-2045(08)70285-7 · 2009 · External reference
Recent progress in the management of hepatocellular carcinoma detected during a surveillance program in Japan
10.1111/j.1872-034x.2010.00706.x · 2010 · External reference
Effect of atorvastatin therapy on borderline vulnerable lesions in patients with acute coronary syndrome
10.5114/aoms.2011.23408 · 2011 · External reference
Manganese-enhanced MRI predicts the histological grade of hepatocellular carcinoma in potential surgical candidates
10.1016/j.crad.2010.08.007 · 2011 · External reference
Surveillance and early diagnosis of hepatocellular carcinoma
10.1016/s1590-8658(10)60509-9 · 2010 · External reference
Hepatocellular carcinoma
10.1016/s0140-6736(03)14964-1 · 2003 · External reference
Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with portal vein tumor thrombosis: analysis of 48 cases
10.1002/cncr.10694 · 2002 · External reference
Intra-arterial therapy with cisplatin suspension in lipiodol and 5-fluorouracil for hepatocellular carcinoma with portal vein tumour thrombosis
10.1111/j.1365-2036.2010.04379.x · 2010 · External reference
Medical treatment of hepatocellular carcinoma
10.1016/s0889-8553(21)00333-2 · 1987 · External reference
Immunotherapy of HCC
10.2174/157488708783330549 · 2008 · External reference
Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival
10.1053/jhep.2003.50047 · 2003 · External reference
Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial
10.1016/s0140-6736(02)08649-x · 2002 · External reference
Hepatocellular carcinoma: the role of the North American GI Steering Committee Hepatobiliary Task Force and the advent of effective drug therapy
10.1634/theoncologist.12-12-1425 · 2007 · External reference
Complete pathological remission is possible with systemic combination chemotherapy for inoperable hepatocellular carcinoma
1999 · External reference
A randomized phase III study of doxorubicin versus cisplatin/interferon α-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma
10.1093/jnci/dji315 · 2005 · External reference
Phase III randomized controlled trial comparing the survival of patients with unresectable hepatocellular carcinoma treated with nolatrexed or doxorubicin
10.1200/jco.2006.08.4046 · 2007 · External reference
Treatment of hepatocellular carcinoma with tamoxifen: a double-blind placebo-controlled trial in 120 patients
10.1016/0016-5085(95)90402-6 · 1995 · External reference
Treatment of hepatocellular carcinoma with combined suppression and inhibition of sex hormones: a randomized, controlled trial
1995 · External reference
Tamoxifen does not improve survival of patients with advanced hepatocellular carcinoma
10.1097/00004836-199804000-00010 · 1998 · External reference
Oral capecitabine for the treatment of hepatocellular carcinoma, cholangiocarcinoma, and gallbladder carcinoma
10.1002/cncr.20368 · 2004 · External reference
A phase II trial of gemcitabine in patients with advanced hepatocellular carcinoma
10.1002/cncr.10607 · 2002 · External reference
A phase 2 study of cisplatin in patients with hepatocellular carcinoma
10.1159/000227142 · 1993 · External reference
5-Fluorouracil and alpha-interferonin hepatocellular carcinoma
10.1097/00000421-199604000-00009 · 1996 · External reference
5-Fluorouracil and high-dose calcium leucovorin for hepatocellular carcinoma: a phase II trial
10.3109/07357909509024907 · 1995 · External reference
Phase II trial of mitoxantrone in advanced primary liver cancer: a Cancer and Leukemia Group B Study
1986 · External reference
Phase 2 study of high dose etoposide (VP16-213) in hepatocellular carcinoma
1987 · External reference
A phase II study of etoposide in patients with hepatocellular carcinoma by the Tokyo Liver Cancer Chemotherapy Study Group
1989 · External reference
Phase II study of fludarabine phosphate in previously untreated patients with colorectal carcinoma: a Southwest Oncology Group Study
1987 · External reference
Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum
10.1016/s1470-2045(04)01508-6 · 2004 · External reference
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
10.1158/0008-5472.can-04-1443 · 2004 · External reference
Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
10.1200/jco.2005.06.124 · 2005 · External reference
BAY 43-9006 inhibition of oncogenic RET mutants
10.1093/jnci/djj069 · 2006 · External reference
Current strategy for staging and treatment: the BCLC update and future prospects
10.1055/s-0030-1247133 · 2010 · External reference
Targeted therapies for hepatocellular carcinoma
10.1053/j.gastro.2011.03.006 · 2011 · External reference
Highly efficacious nontoxic preclinical treatment for advanced metastatic breast cancer using combination oral UFT-cyclophosphamide metronomic chemotherapy
10.1158/0008-5472.can-05-4411 · 2006 · External reference
Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer
10.1158/1535-7163.mct-09-0960 · 2010 · External reference
Acute tubulointerstitial nephritis due to Salmonella typhimurium infection
10.1016/j.ejim.2004.05.009 · 2004 · External reference
Immunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase
10.1158/0008-5472.can-05-0646 · 2005 · External reference
Inhibition of CD4+25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
10.1182/blood-2004-06-2410 · 2005 · External reference
Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts
10.1038/labinvest.2012.65 · 2012 · External reference
Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors
10.1158/0008-5472.can-06-4238 · 2007 · External reference
Antiangiogenesis enhances intratumoral drug retention
10.1158/0008-5472.can-10-3242 · 2011 · External reference
Docetaxel versus paclitaxel for antiangiogenesis
10.1089/152581602753448577 · 2002 · External reference
Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells
10.1158/0008-5472.can-04-2624 · 2005 · External reference
A phase II randomized trial of gefitinib alone or with tegafur/uracil treatment in patients with pulmonary adenocarcinoma who had failed previous chemotherapy
10.1097/jto.0b013e3182121c09 · 2011 · External reference
Anti-angiogenic effect of 5-fluorouracil-based drugs against human colon cancer xenografts
10.1016/j.canlet.2008.03.008 · 2008 · External reference
10.1593/tlo.12295 · 2013 · Admitted local publication
Tumors that acquire resistance to low-dose metronomic cyclophosphamide retain sensitivity to maximum tolerated dose cyclophosphamide
10.1593/neo.101174 · 2011 · External reference
Inhibition of in vitro vascular endothelial cell proliferation and in vivo neovascularization by low-dose methotrexate
10.1002/anr.1780320903 · 1989 · External reference
The microtubule-affecting drug paclitaxel has antiangiogenic activity
1996 · External reference
Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs
2002 · External reference
Antiangiogenesis is produced by nontoxic doses of vinblastine
10.1182/blood.v94.12.4143 · 1999 · External reference
Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly
10.1097/00001813-200301000-00003 · 2003 · External reference
Comparison of antiangiogenic activities using paclitaxel (taxol) and docetaxel (taxotere)
10.1002/ijc.10907 · 2003 · External reference
Endogenous inhibitors of angiogenesis
10.1158/0008-5472.can-04-2427 · 2005 · External reference
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
10.1073/pnas.2135406100 · 2003 · External reference
Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1
10.1593/neo.12772 · 2012 · External reference
Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression
10.1158/0008-5472.can-03-3126 · 2004 · External reference
CD36 mediates the in vitro inhibitory effects of thrombospondin-1 on endothelial cells
10.1083/jcb.138.3.707 · 1997 · External reference
Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells
1997 · External reference
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
10.1038/71517 · 2000 · External reference
Binding and displacement of vascular endothelial growth factor (VEGF) by thrombospondin: effect on human microvascular endothelial cell proliferation and angiogenesis
10.1023/a:1009018702832 · 1999 · External reference
Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition
10.1158/1535-7163.mct-09-0274 · 2009 · External reference
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumorinduced mobilization of circulating angiogenic cells
10.1073/pnas.0812801106 · 2009 · External reference
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
10.1042/cs20040370 · 2005 · External reference
The biology of VEGF and its receptors
10.1038/nm0603-669 · 2003 · External reference
Metronomic low-dose oral cyclophosphamide and methotrexate plus or minus thalidomide in metastatic breast cancer: antitumor activity and biological effects
10.1093/annonc/mdj066 · 2006 · External reference
A novel metronomic chemotherapy regimen of weekly platinum and daily oral etoposide in high-risk non-small cell lung cancer patients
2006 · External reference
Isolation of putative progenitor endothelial cells for angiogenesis
10.1126/science.275.5302.964 · 1997 · External reference
Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization
10.1172/jci6889 · 1999 · External reference
A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature
10.1172/jci24751 · 2006 · External reference
Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy
10.1158/0008-5472.can-04-4337 · 2005 · External reference
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
10.1016/j.cell.2005.02.034 · 2005 · External reference
Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells
2003 · External reference
Classification of chemotherapeutic agents based on their differential in vitro effects on dendritic cells
10.1158/0008-5472.can-09-1101 · 2009 · External reference
CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
10.1007/s00262-005-0092-8 · 2006 · External reference
CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
10.1002/eji.200324181 · 2004 · External reference
Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model
10.1007/s00262-009-0671-1 · 2009 · External reference
Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
10.1007/s00262-006-0225-8 · 2007 · External reference
Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation
10.1158/0008-5472.can-09-1106 · 2009 · External reference
Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water
2002 · External reference
Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts
2002 · External reference
Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis
10.1038/mt.2010.34 · 2010 · External reference
Impact of metronomic UFT/cyclophosphamide chemotherapy and antiangiogenic drug assessed in a new preclinical model of locally advanced orthotopic hepatocellular carcinoma
10.1593/neo.91872 · 2010 · External reference
Low-dose metronomic chemotherapy with cisplatin: can it suppress angiogenesis in H22 hepatocarcinoma cells?
10.1111/j.1365-2613.2009.00684.x · 2010 · External reference
Beneficial effect of metronomic chemotherapy on tumor suppression and survival in a rat model of hepatocellular carcinoma with liver cirrhosis
10.1007/s00280-009-1108-4 · 2010 · External reference
Development of a resistance-like phenotype to sorafenib by human hepatocellular carcinoma cells is reversible and can be delayed by metronomic UFT chemotherapy
10.1593/neo.10804 · 2010 · External reference
Metronomic chemotherapy in combination with antiangiogenic treatment induces mosaic vascular reduction and tumor growth inhibition in hepatocellular carcinoma xenografts
10.1007/s00432-012-1270-7 · 2012 · External reference
Metronomic S-1 chemotherapy and vandetanib: an efficacious and nontoxic treatment for hepatocellular carcinoma
10.1593/neo.101186 · 2011 · External reference
Suppression of hepatic tumor growth and metastasis by metronomic therapy in a rat model of hepatocellular carcinoma
10.3858/emm.2011.43.5.033 · 2011 · External reference
Metronomic chemotherapy: new rationale for new directions
10.1038/nrclinonc.2010.82 · 2010 · External reference
Metronomic chemotherapy for cancer treatment: a decade of clinical studies
10.1007/s00280-013-2125-x · 2013 · External reference
The role of angiogenesis in human non-Hodgkin lymphomas
10.1593/neo.121962 · 2013 · External reference
Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer
10.1186/1471-2407-6-225 · 2006 · External reference
A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung
10.1056/nejmoa032792 · 2004 · External reference
Oral uracil and tegafur compared with classic cyclophosphamide, methotrexate, fluorouracil as postoperative chemotherapy in patients with node-negative, high-risk breast cancer: National Surgical Adjuvant Study for Breast Cancer 01 Trial
10.1200/jco.2008.18.3939 · 2009 · External reference
UKT-04 trial of continuous metronomic low-dose chemotherapy with methotrexate and cyclophosphamide for recurrent glioblastoma
10.1007/s11060-004-1726-y · 2005 · External reference
Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults
10.1215/15228517-2007-006 · 2007 · External reference
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study
10.1038/sj.bjc.6605412 · 2009 · External reference
Randomized phase II trial of chemoradiotherapy followed by either dose-dense or metronomic temozolomide for newly diagnosed glioblastoma
10.1200/jco.2008.20.7944 · 2009 · External reference
Combined oral cyclophosphamide and bevacizumab in heavily pre-treated ovarian cancer
10.1007/s12094-008-0254-7 · 2008 · External reference
Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
10.1200/jco.2007.12.1939 · 2008 · External reference
Strategies for improving the clinical benefit of antiangiogenic drug based therapies for breast cancer
10.1007/s10911-012-9266-0 · 2012 · External reference
Impact of different anticancer regimens on biomarkers of angiogenesis in patients with advanced hepatocellular cancer
10.1007/s00432-008-0443-x · 2009 · External reference
Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma
10.1016/j.jhep.2010.01.035 · 2010 · External reference
Dynamic contrast-enhanced magnetic resonance imaging biomarkers predict survival and response in hepatocellular carcinoma patients treated with sorafenib and metronomic tegafur/uracil
10.1016/j.jhep.2011.01.032 · 2011 · External reference
Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: presence of lung metastasis predicts poor response
10.1002/cncr.24029 · 2009 · External reference
Efficacy and safety of metronomic chemotherapy for patients with advanced primary hepatocellular carcinoma with major portal vein tumor thrombosis
10.3350/kjhep.2012.18.1.32 · 2012 · External reference
Early alphafetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma
10.1002/cncr.25257 · 2010 · External reference
Efficacy, safety, and potential biomarkers of thalidomide plus metronomic chemotherapy for advanced hepatocellular carcinoma
10.1159/000336126 · 2012 · External reference
High circulating endothelial progenitor levels associated with poor survival of advanced hepatocellular carcinoma patients receiving sorafenib combined with metronomic chemotherapy
10.1159/000331684 · 2011 · External reference
Long-lasting response with metronomic capecitabine in advanced hepatocellular carcinoma
10.1177/030089161009600521 · 2010 · External reference
Durable complete response of hepatocellular carcinoma after metronomic capecitabine
10.1177/548.6527 · 2010 · External reference
Clinical, pharmacokinetic and pharmacodynamic evaluations of metronomic UFT and cyclophosphamide plus celecoxib in patients with advanced refractory gastrointestinal cancers
10.1007/s10456-012-9260-6 · 2012 · External reference