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References from Inhibition of DNA demethylation attenuates experimental necrotizing enterocolitis via suppression of TLR4-mediated inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
Neonatal Necrotizing Enterocolitis -Inflammation and Intestinal Immaturity
10.2174/187152309789152020 · 2009 · External reference
Unresolved reference
2023 · External reference
Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis
10.1186/s12887-020-02231-5 · 2020 · External reference
Defining necrotizing enterocolitis: current difficulties and future opportunities
10.1038/s41390-020-1074-4 · 2020 · External reference
Contemporary Outcomes for Infants with Necrotizing Enterocolitis-A Systematic Review
10.1016/j.jpeds.2019.11.011 · 2020 · External reference
Necrotizing enterocolitis
10.1056/nejmra1005408 · 2011 · External reference
Royal Australasia of Surgeons Guest Lecture. Necrotizing enterocolitis: prevention, treatment, and outcome
10.1016/j.jpedsurg.2013.08.006 · 2013 · External reference
Unresolved reference
2021 · External reference
Unresolved reference
2021 · External reference
Antibiotic therapy and necrotizing enterocolitis
10.1016/j.sempedsurg.2023.151308 · 2023 · External reference
Coagulation Gene Expression Profiling in Infants With Necrotizing Enterocolitis
10.1097/mpg.0000000000001215 · 2016 · External reference
Deoxycholic acid aggravates necrotizing enterocolitis through downregulation of mesenchymal-epithelial transition factor expression
10.1590/1414-431x2024e14046 · 2024 · External reference
Gene expression profiling in necrotizing enterocolitis reveals pathways common to those reported in Crohn's disease
10.1186/s12920-016-0166-9 · 2016 · External reference
Targeted RNA sequencing identified gene expression profiles linked to severe necrosis and mortality in preterm infants with surgical necrotizing enterocolitis
2025 · External reference
Intestinal cytokine gene expression in infants with acute necrotizing enterocolitis: interleukin-11 mRNA expression inversely correlates with extent of disease
10.1053/jpsu.2001.25726 · 2001 · External reference
Gene expression profile of necrotizing enterocolitis model in neonatal mice
10.1016/j.ijsu.2015.09.049 · 2015 · External reference
Selective hypermethylation is evident in small intestine samples from infants with necrotizing enterocolitis
10.1186/s13148-022-01266-y · 2022 · External reference
Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis
10.1186/s13148-020-00983-6 · 2020 · External reference
Neonatal necrotizing enterocolitis-associated DNA methylation signatures in the colon are evident in stool samples of affected individuals
10.2217/epi-2021-0078 · 2021 · External reference
Detection of an intestinal cell DNA methylation signature in blood samples from neonates with necrotizing enterocolitis
10.1080/17501911.2025.2459552 · 2025 · External reference
Hypermethylation of CTDSPL2 prior to necrotizing enterocolitis onset
10.2217/epi-2023-0119 · 2023 · External reference
Multi-strain probiotic administration decreases necrotizing enterocolitis severity and alters the epigenetic profile in mice
10.1038/s41390-024-03716-0 · 2025 · External reference
DNA Methylation of TLR4, VEGFA, and DEFA5 Is Associated With Necrotizing Enterocolitis in Preterm Infants
10.3389/fped.2021.630817 · 2021 · External reference
Epigenetic changes associated with severe necrosis and survival in preterm infants with surgical necrotizing enterocolitis
2025 · External reference
Marked methylation changes in intestinal genes during the perinatal period of preterm neonates
10.1186/1471-2164-15-716 · 2014 · External reference
Epigenome-Microbiome crosstalk: A potential new paradigm influencing neonatal susceptibility to disease
10.1080/15592294.2016.1155011 · 2016 · External reference
Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs
10.1093/dnares/dsy001 · 2018 · External reference
Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer
10.3748/wjg.v28.i40.5845 · 2022 · External reference
TET1 Knockdown Inhibits Porphyromonas gingivalis LPS/IFN-γ-Induced M1 Macrophage Polarization through the NF-κB Pathway in THP-1 Cells
2019 · External reference
TET1 is an important transcriptional activator of TNFα expression in macrophages
10.1371/journal.pone.0218551 · 2019 · External reference
Formation and sequence analysis of secretoneurin, a neuropeptide derived from secretogranin II, in mammalian, bird, reptile, amphibian and fish brains
10.1016/s0304-3940(98)00345-0 · 1998 · External reference
TET2 promotes IL-1β expression in J774.1 cells through TLR4/MAPK signaling pathway with demethylation of TAB2 promoter
10.1016/j.molimm.2020.08.003 · 2020 · External reference
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
10.1126/science.1170116 · 2009 · External reference
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
10.1126/science.1210944 · 2011 · External reference
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
10.1126/science.1210597 · 2011 · External reference
Glutamine with probiotics attenuates intestinal inflammation and oxidative stress in a rat burn injury model through altered iNOS gene aberrant methylation
2017 · External reference
DNA methylcytosine dioxygenase ten-eleven translocation 2 enhances lipopolysaccharide-induced cytokine expression in human dental pulp cells by regulating MyD88 hydroxymethylation
10.1007/s00441-018-2826-x · 2018 · External reference
TET2 and TET3 loss disrupts small intestine differentiation and homeostasis
10.1038/s41467-023-39512-3 · 2023 · External reference
Unresolved reference
External reference
Unresolved reference
2022 · External reference
Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration
10.1016/j.xcrm.2021.100320 · 2021 · External reference
Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays
10.1136/gutjnl-2013-306651 · 2015 · External reference
Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
10.3791/65605 · 2023 · External reference
Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions
10.1016/j.celrep.2019.01.108 · 2019 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
Urolithin A attenuates inflammation and enhances barrier integrity in an experimental NEC-in-a-Dish model
2026 · External reference
Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut
10.4049/jimmunol.1402490 · 2015 · External reference
A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair
10.4049/jimmunol.179.7.4808 · 2007 · External reference
DNA methylation in necrotizing enterocolitis
10.1017/erm.2024.16 · 2024 · External reference
Tet2 restrains inflammatory gene expression in macrophages
10.1016/j.exphem.2017.08.001 · 2017 · External reference
Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by Escherichia coli
2021 · External reference
Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression
10.1093/intimm/dxz008 · 2019 · External reference
Unresolved reference
2019 · External reference
TET proteins regulate the lineage specification and TCR-mediated expansion of iNKT cells
10.1038/ni.3630 · 2017 · External reference
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6
10.1038/nature15252 · 2015 · External reference
Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis
10.1093/eurheartj/ehae546 · 2024 · External reference
Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis
10.1038/s44161-023-00281-3 · 2023 · External reference
Unresolved reference
2025 · External reference
Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism
10.1161/circresaha.124.324492 · 2024 · External reference
10.1158/2643-3230.c.8335703
10.1158/2643-3230.c.8335703 · External reference
Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling
10.1182/blood.2022016835 · 2023 · External reference
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
10.1016/j.stem.2018.10.013 · 2018 · External reference
Cytosine-Based TET Enzyme Inhibitors
10.1021/acsmedchemlett.8b00474 · 2019 · External reference
The Binomial Inflammation-Epigenetics in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell Line
10.3390/ijms232315422 · 2022 · External reference
The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of the TET2/NLRP3 inflammasome signaling pathway
10.1016/j.kint.2025.04.016 · 2025 · External reference
Vitamin C enhances cisplatin sensitivity in bladder cancer via 5hmC-mediated epigenetic modulation of ATF4
10.1186/s13148-025-02011-x · 2025 · External reference
Ferroptosis inhibitor ferrostatin–1 alleviates homocysteine–induced ovarian granulosa cell injury by regulating TET activity and DNA methylation
2022 · External reference
Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells
10.1074/jbc.m113.460386 · 2013 · External reference
Unresolved reference
2013 · External reference
TET3-OGT interaction increases the stability and the presence of OGT in chromatin
10.1111/gtc.12107 · 2014 · External reference
Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT)
10.1074/jbc.m113.524140 · 2014 · External reference
10.1038/s41594-025-01505-9
10.1038/s41594-025-01505-9 · External reference
Toll-Like Receptor-Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis
10.1016/j.jcmgh.2018.04.001 · 2018 · External reference
Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation
10.1101/gad.288035.116 · 2016 · External reference
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development
10.1136/gutjnl-2017-314817 · 2019 · External reference
