Research graph
References from Pleiotropic genetic architecture linking schizophrenia and substance use disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevalence of psychotic disorders and its association with methodological issues. A systematic review and meta-analyses
10.1371/journal.pone.0195687 · External reference
10.1016/s0140-6736(15)01121-6
10.1016/s0140-6736(15)01121-6 · 2016 · External reference
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
10.1038/s41586-022-04434-5 · 2022 · External reference
Cannabis use disorders in the USA: Prevalence, correlates and co-morbidity
10.1017/s0033291706008361 · 2006 · External reference
Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse: Results From the Epidemiologic Catchment Area (ECA) Study
10.1001/jama.1990.03450190043026 · 1990 · External reference
Genetics of substance use disorders: a review
10.1017/s0033291721000969 · 2021 · External reference
Characteristics of subgroups of individuals with psychotic illness and a comorbid substance use disorder
10.1176/appi.ps.54.4.554 · 2003 · External reference
Substance use in a population-based clinic sample of people with first-episode psychosis
10.1192/bjp.bp.106.024448 · 2007 · External reference
Initiation of daily smoking and nicotine dependence in schizophrenia and mood disorders
10.1016/s0920-9964(01)00217-1 · 2002 · External reference
Opioid use and schizophrenia
10.1097/yco.0000000000000593 · 2020 · External reference
Substance Use Disorders in Schizophrenia—Clinical Implications of Comorbidity
10.1093/schbul/sbp016 · 2009 · External reference
Comorbid substance use disorder in schizophrenia: a selective overview of neurobiological and cognitive underpinnings
10.1111/pcn.12072 · 2013 · External reference
The link between schizophrenia and substance use disorder: A unifying hypothesis
10.1016/j.schres.2017.04.016 · 2018 · External reference
Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci
10.1111/add.15680 · 2022 · External reference
Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking
10.1038/s41386-024-01886-3 · 2024 · External reference
Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression
10.1111/adb.13282 · 2023 · External reference
A genetically informed study of the relationship between cannabis use, schizophrenia, and bipolar disorder
10.1016/s2215-0366(23)00143-8 · 2023 · External reference
The genetic relationship between cannabis use disorder, cannabis use and psychiatric disorders
10.1038/s44220-025-00440-4 · 2025 · External reference
Mapping the genetic landscape across 14 psychiatric disorders
10.1038/s41586-025-09820-3 · External reference
Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications
10.1038/s41588-023-01563-z · 2023 · External reference
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
10.1038/s41591-023-02653-5 · 2023 · External reference
Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes
10.1101/2023.03.27.23287713 · External reference
Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction
10.1038/s41593-022-01160-z · 2022 · External reference
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
10.1038/s44220-023-00034-y · 2023 · External reference
Shared vulnerability and sex-dependent polygenic burden in psychotic disorders
10.1016/j.euroneuro.2024.04.017 · 2024 · External reference
A longitudinal approach to biological psychiatric research: The PsyCourse study
10.1002/ajmg.b.32639 · 2019 · External reference
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
10.1038/ng.3211 · 2015 · External reference
A global reference for human genetic variation
10.1038/nature15393 · 2015 · External reference
Integrating common and rare genetic variation in diverse human populations
10.1038/nature09298 · 2010 · External reference
An integrated framework for local genetic correlation analysis
10.1038/s41588-022-01017-y · 2022 · External reference
topr: an R package for viewing and annotating genetic association results
10.1186/s12859-023-05301-4 · 2023 · External reference
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
10.1038/s41467-019-10310-0 · 2019 · External reference
Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits
10.1038/s41562-019-0566-x · 2019 · External reference
Unresolved reference
External reference
lavaan: An R Package for Structural Equation Modeling
10.18637/jss.v048.i02 · 2012 · External reference
Polygenic prediction via Bayesian regression and continuous shrinkage priors
10.1038/s41467-019-09718-5 · 2019 · External reference
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
10.1086/519795 · 2007 · External reference
Unresolved reference
2026 · External reference
The MR-base platform supports systematic causal inference across the human phenome
10.7554/elife.34408 · External reference
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
10.1038/s41588-018-0099-7 · 2018 · External reference
Efficient design for mendelian randomization studies: Subsample and 2-sample instrumental variable estimators
10.1093/aje/kwt084 · 2013 · External reference
Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
10.1002/gepi.21965 · 2016 · External reference
Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
10.1093/ije/dyx102 · 2017 · External reference
Orienting the causal relationship between imprecisely measured traits using GWAS summary data
10.1371/journal.pgen.1007081 · 2017 · External reference
Assessing the suitability of summary data for two-sample mendelian randomization analyses using MR-Egger regression: The role of the I 2 statistic
10.1093/ije/dyw220 · 2016 · External reference
Interpreting findings from Mendelian randomization using the MR-Egger method
10.1007/s10654-017-0255-x · 2017 · External reference
PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics
10.1093/bioinformatics/btac228 · 2022 · External reference
Functional mapping and annotation of genetic associations with FUMA
10.1038/s41467-017-01261-5 · 2017 · External reference
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
10.1089/omi.2011.0118 · 2012 · External reference
Relationships between substance abuse/dependence and psychiatric disorders based on polygenic scores
10.1111/gbb.12504 · 2019 · External reference
Cannabis use is associated with 3 years earlier onset of schizophrenia spectrum disorder in a naturalistic, multi-site sample (N = 1119)
10.1016/j.schres.2015.11.027 · 2016 · External reference
