Research graph
References from Genomic Amplification of Metabolic-Risk Rankings Identifies a Candidate Noradrenergic Axis in Antidepressant Liability: Implications for Precision Psychiatry. Local targets link to admitted publications; unresolved targets remain external evidence.
Antidepressants and body weight: a comprehensive review and meta-analysis
10.4088/jcp.09r05346blu · 2010 · External reference
Effects of antidepressant and antipsychotic use on weight gain: a systematic review
10.1111/obr.12934 · 2019 · External reference
Medication-induced weight change across common antidepressant treatments: a target trial emulation study
10.7326/m23-2742 · 2024 · External reference
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis
10.1016/s0140-6736(25)01293-0 · 2025 · External reference
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
10.1038/sj.npp.1300027 · 2003 · External reference
Receptor occupancy-based analysis of the contributions of various receptors to antipsychotic-induced weight gain and diabetes mellitus
10.2133/dmpk.20.368 · 2005 · External reference
Mechanisms underlying metabolic disturbances associated with psychosis and antipsychotic drug treatment
10.1177/0269881117722987 · 2017 · External reference
Antipsychotic drugs: from receptor-binding profiles to metabolic side effects
10.2174/1570159x15666170630163616 · 2018 · External reference
Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
10.1073/pnas.0611417104 · 2007 · External reference
Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors
10.1210/en.2007-1321 · 2008 · External reference
Brain serotonin system in the coordination of food intake and body weight
10.1016/j.pbb.2010.09.003 · 2010 · External reference
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
10.1038/374542a0 · 1995 · External reference
The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C
10.1172/jci93362 · 2017 · External reference
Molecular mechanisms of antipsychotic drug-induced diabetes
10.3389/fnins.2017.00643 · 2017 · External reference
Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia
10.2337/diabetes.54.5.1552 · 2005 · External reference
Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor
10.1007/s40263-013-0115-5 · 2013 · External reference
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
10.1038/35065604 · 2001 · External reference
Mechanisms linking obesity to insulin resistance and type 2 diabetes
10.1038/nature05482 · 2006 · External reference
Insulin receptor signaling in normal and insulin-resistant states
10.1101/cshperspect.a009191 · 2014 · External reference
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
10.1126/science.292.5522.1728 · 2001 · External reference
Olanzapine impairs glycogen synthesis and insulin signaling in L6 skeletal muscle cells
10.1038/sj.mp.4001729 · 2005 · External reference
Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease
10.2337/db13-0430 · 2013 · External reference
The importance of free fatty acids in the development of type 2 diabetes
10.1111/j.1464-5491.2007.02186.x · 2007 · External reference
Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants
10.1002/cpt.2903 · 2023 · External reference
Serotonin transporter genetic variation and antidepressant response and tolerability: a systematic review and meta-analysis
10.3390/jpm11121334 · 2021 · External reference
Understanding genetic risk factors for common side effects of antidepressant medications
10.1038/s43856-021-00046-8 · 2021 · External reference
Risperidone-related weight gain: genetic and nongenetic predictors
10.1097/01.jcp.0000203196.65710.2b · 2006 · External reference
Association between kidney stones and CKD: a bidirectional Mendelian randomization study
10.1681/asn.0000000000000453 · 2024 · External reference
H1-histamine receptor affinity predicts weight gain with antidepressants
10.1016/j.euroneuro.2016.08.012 · 2016 · External reference
Neuronal circuits that regulate feeding behavior and metabolism
10.1016/j.tem.2013.05.003 · 2013 · External reference
Peripheral innervation in the regulation of glucose homeostasis
10.1016/j.tins.2020.10.015 · 2021 · External reference
Neural innervation of white adipose tissue and the control of lipolysis
10.1016/j.yfrne.2014.04.001 · 2014 · External reference
Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A genotypes and serotonin reuptake inhibitor antidepressants
10.1002/cpt.2903 · ExternalCitation · doi-reference
Second generation antipsychotic-induced type 2 diabetes: a role for the muscarinic M3 receptor
10.1007/s40263-013-0115-5 · ExternalCitation · doi-reference
H1-histamine receptor affinity predicts weight gain with antidepressants
10.1016/j.euroneuro.2016.08.012 · ExternalCitation · doi-reference
Brain serotonin system in the coordination of food intake and body weight
10.1016/j.pbb.2010.09.003 · ExternalCitation · doi-reference
Neuronal circuits that regulate feeding behavior and metabolism
10.1016/j.tem.2013.05.003 · ExternalCitation · doi-reference
Peripheral innervation in the regulation of glucose homeostasis
10.1016/j.tins.2020.10.015 · ExternalCitation · doi-reference
Neural innervation of white adipose tissue and the control of lipolysis
10.1016/j.yfrne.2014.04.001 · ExternalCitation · doi-reference
The effects of antidepressants on cardiometabolic and other physiological parameters: a systematic review and network meta-analysis
10.1016/s0140-6736(25)01293-0 · ExternalCitation · doi-reference
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean
10.1038/35065604 · ExternalCitation · doi-reference
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
10.1038/374542a0 · ExternalCitation · doi-reference
Mechanisms linking obesity to insulin resistance and type 2 diabetes
10.1038/nature05482 · ExternalCitation · doi-reference
Understanding genetic risk factors for common side effects of antidepressant medications
10.1038/s43856-021-00046-8 · ExternalCitation · doi-reference
Olanzapine impairs glycogen synthesis and insulin signaling in L6 skeletal muscle cells
10.1038/sj.mp.4001729 · ExternalCitation · doi-reference
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs
10.1038/sj.npp.1300027 · ExternalCitation · doi-reference
Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase
10.1073/pnas.0611417104 · ExternalCitation · doi-reference
Risperidone-related weight gain: genetic and nongenetic predictors
10.1097/01.jcp.0000203196.65710.2b · ExternalCitation · doi-reference
Insulin receptor signaling in normal and insulin-resistant states
10.1101/cshperspect.a009191 · ExternalCitation · doi-reference
The importance of free fatty acids in the development of type 2 diabetes
10.1111/j.1464-5491.2007.02186.x · ExternalCitation · doi-reference
Effects of antidepressant and antipsychotic use on weight gain: a systematic review
10.1111/obr.12934 · ExternalCitation · doi-reference
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
10.1126/science.292.5522.1728 · ExternalCitation · doi-reference
The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C
10.1172/jci93362 · ExternalCitation · doi-reference
Mechanisms underlying metabolic disturbances associated with psychosis and antipsychotic drug treatment
10.1177/0269881117722987 · ExternalCitation · doi-reference
Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors
10.1210/en.2007-1321 · ExternalCitation · doi-reference
Association between kidney stones and CKD: a bidirectional Mendelian randomization study
10.1681/asn.0000000000000453 · ExternalCitation · doi-reference
Receptor occupancy-based analysis of the contributions of various receptors to antipsychotic-induced weight gain and diabetes mellitus
10.2133/dmpk.20.368 · ExternalCitation · doi-reference
Antipsychotic drugs: from receptor-binding profiles to metabolic side effects
10.2174/1570159x15666170630163616 · ExternalCitation · doi-reference
Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease
10.2337/db13-0430 · ExternalCitation · doi-reference
Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia
10.2337/diabetes.54.5.1552 · ExternalCitation · doi-reference
Molecular mechanisms of antipsychotic drug-induced diabetes
10.3389/fnins.2017.00643 · ExternalCitation · doi-reference
Serotonin transporter genetic variation and antidepressant response and tolerability: a systematic review and meta-analysis
10.3390/jpm11121334 · ExternalCitation · doi-reference
Antidepressants and body weight: a comprehensive review and meta-analysis
10.4088/jcp.09r05346blu · ExternalCitation · doi-reference
Medication-induced weight change across common antidepressant treatments: a target trial emulation study
10.7326/m23-2742 · ExternalCitation · doi-reference
