Research graph
References from Orbital Spaceflight Remodels miRNA Expression and Suppresses miRNA Biogenesis Machinery in Astronaut PBMCs. Local targets link to admitted publications; unresolved targets remain external evidence.
Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration
10.1016/j.cell.2020.10.050 · 2020 · External reference
The NASA Twins Study: a multidimensional analysis of a year-long human spaceflight
10.1126/science.aau8650 · 2019 · External reference
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
10.1016/j.cell.2020.11.002 · 2020 · External reference
Direct RNA sequencing of astronaut blood reveals transcriptomic and epitranscriptomic adaptations to spaceflight
10.1038/s41467-024-48929-3 · 2024 · External reference
Unresolved reference
2018 · External reference
MicroRNAs: small RNAs with a big role in gene regulation
10.1038/nrg1379 · 2004 · External reference
Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
10.1038/s41580-018-0059-1 · 2019 · External reference
Posttranscriptional crossregulation between Drosha and DGCR8
2009 · External reference
Unresolved reference
2016 · External reference
Structural features within precursor microRNA-20a regulate Dicer–TRBP processing
2025 · External reference
Unresolved reference
2025 · External reference
AGO–RBP crosstalk on target mRNAs: an emerging mechanism of post-transcriptional gene regulation
2022 · External reference
Advances in miRNA research: unraveling the complexities of gene regulation
2025 · External reference
Mechanisms of post-transcriptional regulation by microRNAs
10.1038/nrg2290 · 2008 · External reference
Circulating miRNA spaceflight signature reveals targets for countermeasure development
10.1016/j.celrep.2020.108448 · 2020 · External reference
Beyond low-Earth orbit: characterizing immune and microRNA differentials following simulated deep-spaceflight conditions in mice
10.1016/j.isci.2020.101747 · 2020 · External reference
The role of microRNAs in human cells exposed to spatially simulated microgravity and real microgravity
2016 · External reference
Microgravity influences microRNA expression in human follicular thyroid cancer cells
2016 · External reference
A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response
10.1371/journal.pone.0199621 · 2018 · External reference
Transient gene and microRNA expression profile changes of confluent human fibroblast cells in spaceflight
10.1096/fj.201500121 · 2016 · External reference
Systematic analysis of mRNA and miRNA expression of 3D-cultured neural stem cells in spaceflight
10.3389/fncel.2017.00434 · 2018 · External reference
Changes in miRNA expression profile of space-flown Caenorhabditis elegans during the Shenzhou-8 mission
2014 · External reference
Space flight-associated changes in astronauts’ plasma-derived small extracellular vesicle microRNA: biomarker identification
10.1002/ctm2.845 · 2022 · External reference
Immune system dysregulation during spaceflight: potential countermeasures for deep space exploration missions
10.3389/fimmu.2018.01437 · 2018 · External reference
MicroRNAs responding to space radiation
10.3390/ijms21186603 · 2020 · External reference
Emerging role of exosomal long non-coding RNAs in spaceflight-associated risks in astronauts
10.3389/fgene.2021.812188 · 2022 · External reference
10.1101/2025.04.09.647940
10.1101/2025.04.09.647940 · 2025 · External reference
Use of ranks in one-criterion variance analysis
10.1080/01621459.1952.10483441 · 1952 · External reference
10.64898/2026.06.01.729304
10.64898/2026.06.01.729304 · 2026 · External reference
The transcriptome response of astronaut leukocytes to long missions aboard the International Space Station reveals immune modulation
10.3389/fimmu.2023.1171103 · 2023 · External reference
Inspiration4 data access through the NASA Open Science Data Repository
10.1038/s41526-024-00393-5 · 2024 · External reference
Aging and putative frailty biomarkers are altered by spaceflight
10.1038/s41598-024-57948-5 · 2024 · External reference
Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel
10.1038/s41598-024-79315-0 · 2024 · External reference
Unresolved reference
2024 · External reference
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA
10.1093/emboj/cdf620 · 2002 · External reference
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
10.1038/s41586-024-07639-y · 2024 · External reference
Molecular and physiological changes in the SpaceX Inspiration4 civilian crew
10.1038/s41586-024-07648-x · 2024 · External reference
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
10.1038/s41467-024-49211-2 · 2024 · External reference
Unresolved reference
External reference
Space flight-associated changes in astronauts’ plasma-derived small extracellular vesicle microRNA: biomarker identification
10.1002/ctm2.845 · ExternalCitation · doi-reference
Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration
10.1016/j.cell.2020.10.050 · ExternalCitation · doi-reference
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
10.1016/j.cell.2020.11.002 · ExternalCitation · doi-reference
Circulating miRNA spaceflight signature reveals targets for countermeasure development
10.1016/j.celrep.2020.108448 · ExternalCitation · doi-reference
Beyond low-Earth orbit: characterizing immune and microRNA differentials following simulated deep-spaceflight conditions in mice
10.1016/j.isci.2020.101747 · ExternalCitation · doi-reference
MicroRNAs: small RNAs with a big role in gene regulation
10.1038/nrg1379 · ExternalCitation · doi-reference
Mechanisms of post-transcriptional regulation by microRNAs
10.1038/nrg2290 · ExternalCitation · doi-reference
Direct RNA sequencing of astronaut blood reveals transcriptomic and epitranscriptomic adaptations to spaceflight
10.1038/s41467-024-48929-3 · ExternalCitation · doi-reference
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
10.1038/s41467-024-49211-2 · ExternalCitation · doi-reference
Inspiration4 data access through the NASA Open Science Data Repository
10.1038/s41526-024-00393-5 · ExternalCitation · doi-reference
Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
10.1038/s41580-018-0059-1 · ExternalCitation · doi-reference
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
10.1038/s41586-024-07639-y · ExternalCitation · doi-reference
Molecular and physiological changes in the SpaceX Inspiration4 civilian crew
10.1038/s41586-024-07648-x · ExternalCitation · doi-reference
Aging and putative frailty biomarkers are altered by spaceflight
10.1038/s41598-024-57948-5 · ExternalCitation · doi-reference
Impact of microgravity and lunar gravity on murine skeletal and immune systems during space travel
10.1038/s41598-024-79315-0 · ExternalCitation · doi-reference
Use of ranks in one-criterion variance analysis
10.1080/01621459.1952.10483441 · ExternalCitation · doi-reference
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA
10.1093/emboj/cdf620 · ExternalCitation · doi-reference
Transient gene and microRNA expression profile changes of confluent human fibroblast cells in spaceflight
10.1096/fj.201500121 · ExternalCitation · doi-reference
10.1101/2025.04.09.647940
10.1101/2025.04.09.647940 · ExternalCitation · doi-reference
The NASA Twins Study: a multidimensional analysis of a year-long human spaceflight
10.1126/science.aau8650 · ExternalCitation · doi-reference
A microRNA signature and TGF-β1 response were identified as the key master regulators for spaceflight response
10.1371/journal.pone.0199621 · ExternalCitation · doi-reference
Emerging role of exosomal long non-coding RNAs in spaceflight-associated risks in astronauts
10.3389/fgene.2021.812188 · ExternalCitation · doi-reference
Immune system dysregulation during spaceflight: potential countermeasures for deep space exploration missions
10.3389/fimmu.2018.01437 · ExternalCitation · doi-reference
The transcriptome response of astronaut leukocytes to long missions aboard the International Space Station reveals immune modulation
10.3389/fimmu.2023.1171103 · ExternalCitation · doi-reference
Systematic analysis of mRNA and miRNA expression of 3D-cultured neural stem cells in spaceflight
10.3389/fncel.2017.00434 · ExternalCitation · doi-reference
MicroRNAs responding to space radiation
10.3390/ijms21186603 · ExternalCitation · doi-reference
10.64898/2026.06.01.729304
10.64898/2026.06.01.729304 · ExternalCitation · doi-reference
