Research graph
References from DJ-1 Protein Ameliorates Mitochondrial Dynamics Imbalance via the PGC1α/DRP1 Pathway in Parkinson's Disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Parkinson's disease pathogenesis and therapeutic strategies
2026 · External reference
Unresolved reference
External reference
DJ-1 alleviates anoxia and hypoglycemia injury in cardiac microvascular via AKT and GSH
10.1016/j.mcp.2020.101600 · External reference
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease
10.1007/s12035-014-8893-4 · External reference
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
10.1038/s41593-022-01140-3 · 2022 · External reference
Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
10.1111/j.1471-4159.2012.07734.x · 2012 · External reference
Pathogenesis of DJ-1/PARK7-Mediated Parkinson's Disease
10.3390/cells13040296 · External reference
IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells
10.3390/ijms25147679 · 2024 · External reference
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway
10.1186/s12967-024-05089-8 · 2024 · External reference
DJ-1 binds to mitochondrial complex I and maintains its activity
10.1016/j.bbrc.2009.10.025 · 2009 · External reference
The Parkinson's Disease-Associated Protein DJ-1 Protects Dictyostelium Cells from AMPK-Dependent Outcomes of Oxidative Stress
10.3390/cells10081874 · External reference
Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients
10.1016/j.bbrc.2004.05.187 · 2004 · External reference
Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
10.1038/s41392-023-01353-3 · 2023 · External reference
Mitochondrial dysfunction in Parkinson's disease - a key disease hallmark with therapeutic potential
10.1186/s13024-023-00676-7 · 2023 · External reference
Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease
10.1042/bst20130189 · 2013 · External reference
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease
10.1186/s40478-024-01915-8 · 2024 · External reference
A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction
10.1016/j.heliyon.2023.e14039 · 2023 · External reference
Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation
10.1038/s41401-023-01104-8 · 2023 · External reference
Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
10.3390/nu14071504 · External reference
Differential DJ-1 gene expression in Parkinson's disease
10.1016/j.nbd.2009.08.011 · 2009 · External reference
Mutant-TMEM230-induced neurodegeneration and impaired axonal mitochondrial transport
10.1093/hmg/ddab128 · External reference
The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells
10.1038/s41419-019-1833-5 · 2019 · External reference
Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson's disease model
10.1186/s13578-023-01068-6 · 2023 · External reference
DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission
10.1016/j.yjmcc.2016.04.008 · 2016 · External reference
Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation
10.1093/hmg/ddn230 · 2008 · External reference
Study on the role of Dihuang Yinzi in regulating the AMPK/SIRT1/PGC-1α pathway to promote mitochondrial biogenesis and improve Alzheimer's disease
10.1016/j.jep.2024.118859 · 2025 · External reference
Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway
10.1111/jpi.12491 · 2018 · External reference
PGC-1α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure
10.3389/fcell.2022.871357 · 2022 · External reference
Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease
10.1002/adma.202304654 · 2023 · External reference
Nanoparticles for drug delivery in Parkinson's disease
10.1007/s00415-020-10291-x · 2021 · External reference
Brain-Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha-Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease
10.1002/adma.202304654 · ExternalCitation · doi-reference
Nanoparticles for drug delivery in Parkinson's disease
10.1007/s00415-020-10291-x · ExternalCitation · doi-reference
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease
10.1007/s12035-014-8893-4 · ExternalCitation · doi-reference
Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients
10.1016/j.bbrc.2004.05.187 · ExternalCitation · doi-reference
DJ-1 binds to mitochondrial complex I and maintains its activity
10.1016/j.bbrc.2009.10.025 · ExternalCitation · doi-reference
A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction
10.1016/j.heliyon.2023.e14039 · ExternalCitation · doi-reference
Study on the role of Dihuang Yinzi in regulating the AMPK/SIRT1/PGC-1α pathway to promote mitochondrial biogenesis and improve Alzheimer's disease
10.1016/j.jep.2024.118859 · ExternalCitation · doi-reference
DJ-1 alleviates anoxia and hypoglycemia injury in cardiac microvascular via AKT and GSH
10.1016/j.mcp.2020.101600 · ExternalCitation · doi-reference
Differential DJ-1 gene expression in Parkinson's disease
10.1016/j.nbd.2009.08.011 · ExternalCitation · doi-reference
DJ-1 protects the heart against ischemia-reperfusion injury by regulating mitochondrial fission
10.1016/j.yjmcc.2016.04.008 · ExternalCitation · doi-reference
Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions
10.1038/s41392-023-01353-3 · ExternalCitation · doi-reference
Loss of DJ-1 function contributes to Parkinson's disease pathogenesis in mice via RACK1-mediated PKC activation and MAO-B upregulation
10.1038/s41401-023-01104-8 · ExternalCitation · doi-reference
The effect of cysteine oxidation on DJ-1 cytoprotective function in human alveolar type II cells
10.1038/s41419-019-1833-5 · ExternalCitation · doi-reference
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
10.1038/s41593-022-01140-3 · ExternalCitation · doi-reference
Monitoring mitochondrial dynamics and complex I dysfunction in neurons: implications for Parkinson's disease
10.1042/bst20130189 · ExternalCitation · doi-reference
Mutant-TMEM230-induced neurodegeneration and impaired axonal mitochondrial transport
10.1093/hmg/ddab128 · ExternalCitation · doi-reference
Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation
10.1093/hmg/ddn230 · ExternalCitation · doi-reference
Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction
10.1111/j.1471-4159.2012.07734.x · ExternalCitation · doi-reference
Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1α pathway
10.1111/jpi.12491 · ExternalCitation · doi-reference
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway
10.1186/s12967-024-05089-8 · ExternalCitation · doi-reference
Mitochondrial dysfunction in Parkinson's disease - a key disease hallmark with therapeutic potential
10.1186/s13024-023-00676-7 · ExternalCitation · doi-reference
Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson's disease model
10.1186/s13578-023-01068-6 · ExternalCitation · doi-reference
BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease
10.1186/s40478-024-01915-8 · ExternalCitation · doi-reference
PGC-1α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure
10.3389/fcell.2022.871357 · ExternalCitation · doi-reference
The Parkinson's Disease-Associated Protein DJ-1 Protects Dictyostelium Cells from AMPK-Dependent Outcomes of Oxidative Stress
10.3390/cells10081874 · ExternalCitation · doi-reference
Pathogenesis of DJ-1/PARK7-Mediated Parkinson's Disease
10.3390/cells13040296 · ExternalCitation · doi-reference
IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells
10.3390/ijms25147679 · ExternalCitation · doi-reference
Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
10.3390/nu14071504 · ExternalCitation · doi-reference
