Research graph
References from Granzyme A amplifies human neutrophil pyroptosis. Local targets link to admitted publications; unresolved targets remain external evidence.
What's your age again? Determination of human neutrophil half-lives revisited
10.1189/jlb.1112571 · 2013 · External reference
Neutrophils: Between host defence, immune modulation, and tissue injury
10.1371/journal.ppat.1004651 · 2015 · External reference
The neutrophil collective
10.1016/j.cell.2025.11.001 · 2025 · External reference
Peculiarities of cell death mechanisms in neutrophils
10.1038/cdd.2011.75 · 2011 · External reference
Dysregulation of neutrophil in sepsis: recent insights and advances
10.1186/s12964-025-02098-y · 2025 · External reference
Neutrophil disorders and their management
10.1136/jcp.54.1.7 · 2001 · External reference
Unresolved reference
2020 · External reference
CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease
10.1111/eci.12949 · 2018 · External reference
The Neutrophil Life Cycle
10.1016/j.it.2019.04.013 · 2019 · External reference
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
10.1016/j.immuni.2005.01.011 · 2005 · External reference
Rhythmic modulation of the hematopoietic niche through neutrophil clearance
10.1016/j.cell.2013.04.040 · 2013 · External reference
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
10.1038/ncomms14128 · 2017 · External reference
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
10.1038/s41467-019-09397-2 · 2019 · External reference
Neutrophil extracellular traps kill bacteria
10.1126/science.1092385 · 2004 · External reference
Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression
10.1371/journal.pone.0157454 · 2016 · External reference
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
10.1038/s41418-018-0261-x · 2019 · External reference
Untangling "NETosis" from NETs
10.1002/eji.201747053 · 2019 · External reference
Unresolved reference
2021 · External reference
Neutrophil serine proteases: specific regulators of inflammation
10.1038/nri1841 · 2006 · External reference
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
10.1126/sciimmunol.ade5728 · 2022 · External reference
Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation
10.1172/jci.insight.174133 · 2024 · External reference
A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity
10.3390/molecules31040670 · 2026 · External reference
Inherited disorders of granulopoiesis: understanding pathogenesis to advance new therapies
10.1016/j.exphem.2026.105418 · 2026 · External reference
Remold-O'Donnell E. SerpinB1 protects the mature neutrophil reserve in the bone marrow
10.1189/jlb.0810461 · 2011 · External reference
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation
10.1016/j.celrep.2019.05.065 · 2019 · External reference
SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G
10.1182/blood-2012-09-455022 · 2013 · External reference
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
10.1002/jlb.60.5.555 · 1996 · External reference
Expression of granzyme A in human polymorphonuclear neutrophils
10.1111/j.1365-2567.2006.02551.x · 2007 · External reference
Human neutrophils lack granzyme A, granzyme B, and perforin
10.1182/blood-2004-03-0888 · 2004 · External reference
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
10.1016/j.immuni.2005.02.004 · 2005 · External reference
Death by a thousand cuts: granzyme pathways of programmed cell death
10.1146/annurev.immunol.26.021607.090404 · 2008 · External reference
Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe
10.1021/acs.jmedchem.9b02042 · 2020 · External reference
Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo
10.1002/sctm.18-0255 · 2019 · External reference
Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies
10.1016/j.stemcr.2015.01.005 · 2015 · External reference
Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity
10.1177/2050312120966456 · 2020 · External reference
Fed-batch methanol feeding strategy for recombinant protein production by Pichia pastoris in the presence of co-substrate sorbitol
10.1002/yea.1679 · 2009 · External reference
Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A*
10.1074/jbc.m806716200 · 2009 · External reference
Novel Macrocyclic Peptides as Potent and Selective Inhibitors of Human Neutrophil Serine Protease 4
10.1016/j.jmb.2026.169894 · 2026 · External reference
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
10.1038/srep43135 · 2017 · External reference
Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-carbamoylmethylcoumarin (ACC) Fluorophore
10.1021/jo016140o · 2002 · External reference
Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: identification of a distinct gelatinase-containing granule subset by combined immunocytochemistry and subcellular fractionation
10.1182/blood.v82.10.3183.bloodjournal82103183 · 1993 · External reference
Neutrophil granules and secretory vesicles in inflammation
10.1016/j.micinf.2003.09.008 · 2003 · External reference
Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
10.1016/j.bbrc.2008.10.101 · 2008 · External reference
Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells
10.1073/pnas.87.1.83 · 1990 · External reference
Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils
10.1021/jacs.7b04394 · 2017 · External reference
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
10.1126/science.aaz7548 · 2020 · External reference
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells
10.1038/s41418-023-01143-y · 2023 · External reference
Structural mechanisms for regulation of GSDMB pore-forming activity
10.1038/s41586-023-05872-5 · 2023 · External reference
Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing
10.1016/j.immuni.2025.12.009 · 2026 · External reference
Unresolved reference
2016 · External reference
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages
10.1016/j.chembiol.2017.03.009 · 2017 · External reference
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
10.1038/nature22393 · 2017 · External reference
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death
10.1016/j.cell.2008.03.032 · 2008 · External reference
Role of granule proteases in the life and death of neutrophils
10.1016/j.bbrc.2016.11.086 · 2017 · External reference
Granzyme A: an additional weapon of human polymorphonuclear neutrophils (PMNs) in innate immunity?
10.1182/blood-2003-10-3708 · 2004 · External reference
Granzymes A and B are not expressed in human neutrophils
10.1182/blood-2004-03-0858 · 2004 · External reference
Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils
10.1182/blood-2003-04-1069 · 2004 · External reference
Neutrophil serine proteases fine-tune the inflammatory response
10.1016/j.biocel.2007.11.008 · 2008 · External reference
Perturbation of azurophilic granule integrity drives NLRP3-independent IL-1β processing and release in neutrophils
10.1093/jimmun/vkag033 · 2026 · External reference
The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes
10.4049/jimmunol.136.3.1038 · 1986 · External reference
Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages
10.1038/s41419-022-04841-6 · 2022 · External reference
Unresolved reference
2024 · External reference
Pyroptosis Induction and Detection
10.1002/cpim.52 · 2018 · External reference
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
10.4049/jimmunol.1600699 · 2016 · External reference
Non-canonical inflammasome activation targets caspase-11
10.1038/nature10558 · 2011 · External reference
The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding
10.1038/s41419-019-1412-9 · 2019 · External reference
The role of lysosome in regulated necrosis
10.1016/j.apsb.2020.07.003 · 2020 · External reference
Lysosomal membrane permeabilization in cell death: Concepts and challenges
10.1016/j.mito.2014.06.006 · 2014 · External reference
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents
10.4161/15384101.2014.991194 · 2015 · External reference
N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
10.1038/s41467-020-16043-9 · 2020 · External reference
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
10.1016/s1097-2765(02)00599-3 · 2002 · External reference
Pyroptosis Induction and Detection
10.1002/cpim.52 · ExternalCitation · doi-reference
Untangling "NETosis" from NETs
10.1002/eji.201747053 · ExternalCitation · doi-reference
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies
10.1002/jlb.60.5.555 · ExternalCitation · doi-reference
Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo
10.1002/sctm.18-0255 · ExternalCitation · doi-reference
Fed-batch methanol feeding strategy for recombinant protein production by Pichia pastoris in the presence of co-substrate sorbitol
10.1002/yea.1679 · ExternalCitation · doi-reference
The role of lysosome in regulated necrosis
10.1016/j.apsb.2020.07.003 · ExternalCitation · doi-reference
Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity
10.1016/j.bbrc.2008.10.101 · ExternalCitation · doi-reference
Role of granule proteases in the life and death of neutrophils
10.1016/j.bbrc.2016.11.086 · ExternalCitation · doi-reference
Neutrophil serine proteases fine-tune the inflammatory response
10.1016/j.biocel.2007.11.008 · ExternalCitation · doi-reference
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death
10.1016/j.cell.2008.03.032 · ExternalCitation · doi-reference
Rhythmic modulation of the hematopoietic niche through neutrophil clearance
10.1016/j.cell.2013.04.040 · ExternalCitation · doi-reference
The neutrophil collective
10.1016/j.cell.2025.11.001 · ExternalCitation · doi-reference
Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation
10.1016/j.celrep.2019.05.065 · ExternalCitation · doi-reference
Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages
10.1016/j.chembiol.2017.03.009 · ExternalCitation · doi-reference
Inherited disorders of granulopoiesis: understanding pathogenesis to advance new therapies
10.1016/j.exphem.2026.105418 · ExternalCitation · doi-reference
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
10.1016/j.immuni.2005.01.011 · ExternalCitation · doi-reference
Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis
10.1016/j.immuni.2005.02.004 · ExternalCitation · doi-reference
Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing
10.1016/j.immuni.2025.12.009 · ExternalCitation · doi-reference
The Neutrophil Life Cycle
10.1016/j.it.2019.04.013 · ExternalCitation · doi-reference
Novel Macrocyclic Peptides as Potent and Selective Inhibitors of Human Neutrophil Serine Protease 4
10.1016/j.jmb.2026.169894 · ExternalCitation · doi-reference
Neutrophil granules and secretory vesicles in inflammation
10.1016/j.micinf.2003.09.008 · ExternalCitation · doi-reference
Lysosomal membrane permeabilization in cell death: Concepts and challenges
10.1016/j.mito.2014.06.006 · ExternalCitation · doi-reference
Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies
10.1016/j.stemcr.2015.01.005 · ExternalCitation · doi-reference
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
10.1016/s1097-2765(02)00599-3 · ExternalCitation · doi-reference
Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe
10.1021/acs.jmedchem.9b02042 · ExternalCitation · doi-reference
Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils
10.1021/jacs.7b04394 · ExternalCitation · doi-reference
Expedient Solid-Phase Synthesis of Fluorogenic Protease Substrates Using the 7-Amino-4-carbamoylmethylcoumarin (ACC) Fluorophore
10.1021/jo016140o · ExternalCitation · doi-reference
Peculiarities of cell death mechanisms in neutrophils
10.1038/cdd.2011.75 · ExternalCitation · doi-reference
Non-canonical inflammasome activation targets caspase-11
10.1038/nature10558 · ExternalCitation · doi-reference
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
10.1038/nature22393 · ExternalCitation · doi-reference
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death
10.1038/ncomms14128 · ExternalCitation · doi-reference
Neutrophil serine proteases: specific regulators of inflammation
10.1038/nri1841 · ExternalCitation · doi-reference
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
10.1038/s41418-018-0261-x · ExternalCitation · doi-reference
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells
10.1038/s41418-023-01143-y · ExternalCitation · doi-reference
The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding
10.1038/s41419-019-1412-9 · ExternalCitation · doi-reference
Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages
10.1038/s41419-022-04841-6 · ExternalCitation · doi-reference
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
10.1038/s41467-019-09397-2 · ExternalCitation · doi-reference
N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
10.1038/s41467-020-16043-9 · ExternalCitation · doi-reference
Structural mechanisms for regulation of GSDMB pore-forming activity
10.1038/s41586-023-05872-5 · ExternalCitation · doi-reference
Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
10.1038/srep43135 · ExternalCitation · doi-reference
Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells
10.1073/pnas.87.1.83 · ExternalCitation · doi-reference
Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A*
10.1074/jbc.m806716200 · ExternalCitation · doi-reference
Perturbation of azurophilic granule integrity drives NLRP3-independent IL-1β processing and release in neutrophils
10.1093/jimmun/vkag033 · ExternalCitation · doi-reference
CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease
10.1111/eci.12949 · ExternalCitation · doi-reference
Expression of granzyme A in human polymorphonuclear neutrophils
10.1111/j.1365-2567.2006.02551.x · ExternalCitation · doi-reference
Neutrophil extracellular traps kill bacteria
10.1126/science.1092385 · ExternalCitation · doi-reference
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
10.1126/science.aaz7548 · ExternalCitation · doi-reference
Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement
10.1126/sciimmunol.ade5728 · ExternalCitation · doi-reference
Neutrophil disorders and their management
10.1136/jcp.54.1.7 · ExternalCitation · doi-reference
Death by a thousand cuts: granzyme pathways of programmed cell death
10.1146/annurev.immunol.26.021607.090404 · ExternalCitation · doi-reference
Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation
10.1172/jci.insight.174133 · ExternalCitation · doi-reference
Long-term single-cell passaging of human iPSC fully supports pluripotency and high-efficient trilineage differentiation capacity
10.1177/2050312120966456 · ExternalCitation · doi-reference
Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils
10.1182/blood-2003-04-1069 · ExternalCitation · doi-reference
Granzyme A: an additional weapon of human polymorphonuclear neutrophils (PMNs) in innate immunity?
10.1182/blood-2003-10-3708 · ExternalCitation · doi-reference
Granzymes A and B are not expressed in human neutrophils
10.1182/blood-2004-03-0858 · ExternalCitation · doi-reference
Human neutrophils lack granzyme A, granzyme B, and perforin
10.1182/blood-2004-03-0888 · ExternalCitation · doi-reference
SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G
10.1182/blood-2012-09-455022 · ExternalCitation · doi-reference
Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: identification of a distinct gelatinase-containing granule subset by combined immunocytochemistry and subcellular fractionation
10.1182/blood.v82.10.3183.bloodjournal82103183 · ExternalCitation · doi-reference
Dysregulation of neutrophil in sepsis: recent insights and advances
10.1186/s12964-025-02098-y · ExternalCitation · doi-reference
Remold-O'Donnell E. SerpinB1 protects the mature neutrophil reserve in the bone marrow
10.1189/jlb.0810461 · ExternalCitation · doi-reference
What's your age again? Determination of human neutrophil half-lives revisited
10.1189/jlb.1112571 · ExternalCitation · doi-reference
Neutrophil Extracellular Trap Formation Is Independent of De Novo Gene Expression
10.1371/journal.pone.0157454 · ExternalCitation · doi-reference
Neutrophils: Between host defence, immune modulation, and tissue injury
10.1371/journal.ppat.1004651 · ExternalCitation · doi-reference
A Double-Edged Sword: Extracellular Serine Proteases as Facilitators of Infection and Mediators of Immunity
10.3390/molecules31040670 · ExternalCitation · doi-reference
The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes
10.4049/jimmunol.136.3.1038 · ExternalCitation · doi-reference
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
10.4049/jimmunol.1600699 · ExternalCitation · doi-reference
Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents
10.4161/15384101.2014.991194 · ExternalCitation · doi-reference
