Research graph
References from Species-dependent opioid receptor pharmacology in dogs revealed by binding, signaling, and structural analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
State of the art analgesia- recent developments in pharmacological approaches to acute pain management in dogs and cats. Part 1
10.1016/j.tvjl.2018.06.003 · 2018 · External reference
Species differences in pharmacokinetics and pharmacodynamics
10.1007/978-3-642-10324-7_2 · 2010 · External reference
Pharmacogenetics of opioid analgesics in dogs
10.1111/jvp.12452 · 2018 · External reference
Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids
10.1002/j.1532-2149.2011.00070.x · 2012 · External reference
Antinociceptive and adverse effects of mu- and kappa-opioid receptor agonists: a comparison of morphine and U50488-H
10.1111/j.1742-7843.2008.00306.x · 2008 · External reference
Peripheral kappa-opioid agonists for visceral pain
10.1038/sj.bjp.0705763 · 2004 · External reference
Delta opioid receptors in brain function and diseases
10.1016/j.pharmthera.2013.06.003 · 2013 · External reference
Molecular mechanisms and regulation of opioid receptor signaling
10.1146/annurev.pharmtox.40.1.389 · 2000 · External reference
A novel noncanonical signaling pathway for the µ-opioid receptor
10.1124/mol.113.088278 · 2013 · External reference
Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies
10.1038/s41598-020-65589-7 · 2020 · External reference
Receptor endocytosis counteracts the development of opioid tolerance
10.1124/mol.104.004994 · 2005 · External reference
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors
10.1039/d1md00041a · 2021 · External reference
The safety and effectiveness of a long-acting transdermal fentanyl solution compared with oxymorphone for the control of postoperative pain in dogs: a randomized, multicentered clinical study
10.1111/jvp.12096 · 2014 · External reference
Evaluation of histamine release during constant rate infusion of morphine in dogs
10.1111/j.1467-2995.2005.00218.x · 2006 · External reference
Effects of medetomidine and buprenorphine administered for sedation in dogs
10.1111/j.1748-5827.2001.tb02498.x · 2001 · External reference
Comparison of sedative effects induced by medetomidine, medetomidine-midazolam and medetomidine-butorphanol in dogs
10.1292/jvms.56.951 · 1994 · External reference
Dose response to butorphanol administered subcutaneously to increase visceral nociceptive threshold in dogs
10.2460/ajvr.1991.52.11.1826 · 1991 · External reference
Modeling of kappa-opioid receptor/agonists interactions using pharmacophore-based and docking simulations
10.1021/jm991161k · 2000 · External reference
Deciphering the molecular basis of the kappa opioid receptor selectivity: A Molecular Dynamics study
10.1016/j.jmgm.2021.107940 · 2021 · External reference
Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism
10.1124/mol.110.064956 · 2011 · External reference
Intrinsic Efficacy of Opioid Ligands and Its Importance for Apparent Bias, Operational Analysis, and Therapeutic Window
10.1124/mol.119.119214 · 2020 · External reference
Comparison of the in vitro efficacy of mu, delta, kappa and ORL1 receptor agonists and non-selective opioid agonists in dog brain membranes
2006 · External reference
IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
10.1093/nar/gkn728 · 2009 · External reference
Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants
10.3390/ijms22073779 · 2021 · External reference
A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling
10.1074/jbc.m006352200 · 2001 · External reference
Signal transduction correlates of mu opioid agonist intrinsic efficacy: receptor-stimulated [35S]GTP gamma S binding in mMOR-CHO cells and rat thalamus
10.1016/s0022-3565(24)37462-2 · 1998 · External reference
Pharmacokinetics and physiological effects of two intravenous infusion rates of morphine in conscious dogs
10.1111/j.1365-2885.2007.00849.x · 2007 · External reference
Preperitoneal ropivacaine infusion versus epidural ropivacaine-morphine for postoperative analgesia in dogs undergoing ovariohysterectomy: a randomized clinical trial
10.1016/j.vaa.2021.04.009 · 2021 · External reference
Structure of the δ-opioid receptor bound to naltrindole
10.1038/nature11111 · 2012 · External reference
Molecular recognition of morphine and fentanyl by the human µ-opioid receptor
10.1016/j.cell.2022.09.041 · 2022 · External reference
Structural Determinants of Buprenorphine Partial Agonism at the µ-Opioid Receptor
10.1021/acs.jcim.5c00078 · 2025 · External reference
Molecular Interaction Between Butorphanol and κ-Opioid Receptor
10.1213/ane.0000000000005017 · 2020 · External reference
Molecular determinants of ligand efficacy and potency in GPCR signaling
10.1126/science.adh1859 · 2023 · External reference
Pain polymorphisms and opioids: An evidence based review
2019 · External reference
Database resources of the National Center for Biotechnology Information in 2025
10.1093/nar/gkae979 · 2025 · External reference
Protein measurement with the Folin phenol reagent
10.1016/s0021-9258(19)52451-6 · 1951 · External reference
GPCR-radioligand binding assays
10.1016/bs.mcb.2015.11.004 · 2016 · External reference
Calculating receptor number from binding experiments using same compound as radioligand and competitor
10.1016/0165-6147(89)90266-6 · 1989 · External reference
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
10.1016/0006-2952(73)90196-2 · 1973 · External reference
Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor
10.1038/s41467-025-64882-1 · 2025 · External reference
Unresolved reference
2022 · External reference
ColabFold: making protein folding accessible to all
10.1038/s41592-022-01488-1 · 2022 · External reference
Unresolved reference
2025 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
UniProt: the Universal Protein Knowledgebase in 2025
10.1093/nar/gkae1010 · 2024 · External reference
PubChem 2025 update
10.1093/nar/gkae1059 · 2024 · External reference
UCSF ChimeraX: Tools for structure building and analysis
10.1002/pro.4792 · 2023 · External reference
A systematic approach to quantitative Western blot analysis
10.1016/j.ab.2020.113608 · 2020 · External reference
Protter: interactive protein feature visualization and integration with experimental proteomic data
10.1093/bioinformatics/btt607 · 2014 · External reference