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References from HSP70 activates selective autophagy via UBQLN2 to alleviate hSOD1G93A-mediated neurotoxicity in NSC-34 cellular model of ALS. Local targets link to admitted publications; unresolved targets remain external evidence.
Amyotrophic Lateral Sclerosis
10.1001/jama.2026.6385 · 2026 · External reference
Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis
10.1136/jnnp-2016-315018 · External reference
RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice
10.1016/j.ymthe.2025.05.010 · 2025 · External reference
10.2174/1871527317666180827111152
10.2174/1871527317666180827111152 · 2018 · External reference
Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies
10.3389/fncel.2026.1738415 · 2026 · External reference
Ubiquitination-Proteasome System (UPS) and Autophagy Two Main Protein Degradation Machineries in Response to Cell Stress
10.3390/cells11050851 · 2022 · External reference
Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
10.1186/s13041-017-0300-4 · 2017 · External reference
10.1186/s40478-019-0758-7
10.1186/s40478-019-0758-7 · 2019 · External reference
UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
10.1016/j.neuron.2021.04.023 · 2021 · External reference
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
10.1016/j.cell.2016.07.001 · 2016 · External reference
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function
10.1073/pnas.1917371117 · 2020 · External reference
The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation
10.3390/cells9081791 · 2020 · External reference
10.1111/febs.16129
10.1111/febs.16129 · 2020 · External reference
UBQLN2 and HSP70 participate in Parkin-mediated mitophagy by facilitating outer mitochondrial membrane rupture
10.15252/embr.202255859 · 2023 · External reference
10.1007/s11033-023-08619-7
10.1007/s11033-023-08619-7 · 2023 · External reference
Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate
10.1073/pnas.2405964121 · 2024 · External reference
Truncation mutation of CHMP2B disrupts late endosome function but reduces TDP-43 aggregation through HSP70 upregulation
10.1016/j.neuint.2025.105982 · 2025 · External reference
