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References from Critical Roles of DGAT2, IL17D, and PLD6 in Polyploid Giant Cancer Cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation
10.3389/fcell.2024.1410637 · 2024 · External reference
Intratumor Heterogeneity and Treatment Resistance of Solid Tumors with a Focus on Polyploid/Senescent Giant Cancer Cells (PGCCs)
10.3390/ijms241411534 · 2023 · External reference
AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells
10.1158/0008-5472.can-21-2342 · 2022 · External reference
Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization
10.1016/j.jbc.2024.107136 · 2024 · External reference
Presence of cells in the polyaneuploid cancer cell (PACC) state predicts the risk of recurrence in prostate cancer
10.1002/pros.24459 · 2023 · External reference
Circulating Polyploid Giant Cancer Cells, a Potential Prognostic Marker in Patients with Carcinoma
10.3390/ijms25189841 · 2024 · External reference
Polyploid cancer cells reveal signatures of chemotherapy resistance
10.1038/s41388-024-03212-z · 2025 · External reference
Cells in the Polyaneuploid Cancer Cell State Are Prometastatic
10.1158/1541-7786.mcr-24-0689 · 2025 · External reference
Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted
10.3390/ijms23137241 · 2022 · External reference
Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
10.1007/s12032-023-02237-w · 2023 · External reference
Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasis
10.1002/ctm2.1567 · 2024 · External reference
Focus on the molecular mechanisms of cisplatin resistance based on multi-omics approaches
10.1039/d2mo00220e · 2023 · External reference
Construction of a cisplatin-induced polyploid giant cancer cell model
10.3969/j.issn.1004-616x.2024.06.010 · 2024 · External reference
The Gene Ontology knowledgebase in 2023
10.1093/genetics/iyad031 · 2023 · External reference
KEGG for taxonomy-based analysis of pathways and genomes
10.1093/nar/gkac963 · 2023 · External reference
Visualizing and interpreting cancer genomics data via the Xena platform
10.1038/s41587-020-0546-8 · 2020 · External reference
Maftools: efficient and comprehensive analysis of somatic variants in cancer
10.1101/gr.239244.118 · 2018 · External reference
Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells
10.1016/j.jep.2021.113845 · 2021 · External reference
Emodin-8-O-β-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis
10.1016/j.taap.2022.115909 · 2022 · External reference
Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment
10.3389/fphar.2020.00187 · 2020 · External reference
The Immune Landscape of Cancer
10.1016/j.immuni.2018.03.023 · 2018 · External reference
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
10.1016/j.cell.2018.03.034 · 2018 · External reference
Mutational landscape of cancer-driver genes across human cancers
10.1038/s41598-023-39608-2 · 2023 · External reference
Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer
10.1158/1078-0432.ccr-15-2477 · 2016 · External reference
TBCRC 030: a phase II study of preoperative cisplatin versus paclitaxel in triple-negative breast cancer: evaluating the homologous recombination deficiency (HRD) biomarker
10.1016/j.annonc.2020.08.2064 · 2020 · External reference
Increased HRD score in cisplatin resistant penile cancer cells
10.1186/s12885-022-10432-7 · 2022 · External reference
Giants and monsters: Unexpected characters in the story of cancer recurrence
10.1016/bs.acr.2020.03.001 · 2020 · External reference
Targeting autophagy and lipid metabolism in cancer stem cells
10.1016/j.bcp.2023.115550 · 2023 · External reference
Homologous Recombination Deficiency: Concepts, Definitions, and Assays
10.1093/oncolo/oyab053 · 2022 · External reference
The role of DGAT1 and DGAT2 in tumor progression via fatty acid metabolism: A comprehensive review
10.1016/j.ijbiomac.2024.134835 · 2024 · External reference
Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC
10.1172/jci.insight.158429 · 2023 · External reference
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway
10.18632/aging.204208 · 2022 · External reference
Phospholipase D6 activates Wnt/β-catenin signaling through mitochondrial metabolic reprogramming to promote tumorigenesis in colorectal cancer
10.1038/s12276-025-01446-9 · 2025 · External reference
Functional Roles of CD133: More than Stemness Associated Factor Regulated by the Microenvironment
10.1007/s12015-023-10647-6 · 2024 · External reference
The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer
10.3390/ijms242115812 · 2023 · External reference
CD44: a stemness driver, regulator, and marker—all in one?
10.1093/stmcls/sxae060 · 2024 · External reference
Dormant cancer cells and polyploid giant cancer cells: The roots of cancer recurrence and metastasis
10.1002/ctm2.1567 · ExternalCitation · doi-reference
Presence of cells in the polyaneuploid cancer cell (PACC) state predicts the risk of recurrence in prostate cancer
10.1002/pros.24459 · ExternalCitation · doi-reference
Functional Roles of CD133: More than Stemness Associated Factor Regulated by the Microenvironment
10.1007/s12015-023-10647-6 · ExternalCitation · doi-reference
Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
10.1007/s12032-023-02237-w · ExternalCitation · doi-reference
Giants and monsters: Unexpected characters in the story of cancer recurrence
10.1016/bs.acr.2020.03.001 · ExternalCitation · doi-reference
TBCRC 030: a phase II study of preoperative cisplatin versus paclitaxel in triple-negative breast cancer: evaluating the homologous recombination deficiency (HRD) biomarker
10.1016/j.annonc.2020.08.2064 · ExternalCitation · doi-reference
Targeting autophagy and lipid metabolism in cancer stem cells
10.1016/j.bcp.2023.115550 · ExternalCitation · doi-reference
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
10.1016/j.cell.2018.03.034 · ExternalCitation · doi-reference
The role of DGAT1 and DGAT2 in tumor progression via fatty acid metabolism: A comprehensive review
10.1016/j.ijbiomac.2024.134835 · ExternalCitation · doi-reference
The Immune Landscape of Cancer
10.1016/j.immuni.2018.03.023 · ExternalCitation · doi-reference
Transcriptome analysis of polyploid giant cancer cells and their progeny reveals a functional role for p21 in polyploidization and depolyploidization
10.1016/j.jbc.2024.107136 · ExternalCitation · doi-reference
Exploration of components and mechanisms of Polygoni Multiflori Radix-induced hepatotoxicity using siRNA -mediated CYP3A4 or UGT1A1 knockdown liver cells
10.1016/j.jep.2021.113845 · ExternalCitation · doi-reference
Emodin-8-O-β-D-glucopyranoside, a natural hydroxyanthraquinone glycoside from plant, suppresses cancer cell proliferation via p21-CDKs-Rb axis
10.1016/j.taap.2022.115909 · ExternalCitation · doi-reference
Phospholipase D6 activates Wnt/β-catenin signaling through mitochondrial metabolic reprogramming to promote tumorigenesis in colorectal cancer
10.1038/s12276-025-01446-9 · ExternalCitation · doi-reference
Polyploid cancer cells reveal signatures of chemotherapy resistance
10.1038/s41388-024-03212-z · ExternalCitation · doi-reference
Visualizing and interpreting cancer genomics data via the Xena platform
10.1038/s41587-020-0546-8 · ExternalCitation · doi-reference
Mutational landscape of cancer-driver genes across human cancers
10.1038/s41598-023-39608-2 · ExternalCitation · doi-reference
Focus on the molecular mechanisms of cisplatin resistance based on multi-omics approaches
10.1039/d2mo00220e · ExternalCitation · doi-reference
The Gene Ontology knowledgebase in 2023
10.1093/genetics/iyad031 · ExternalCitation · doi-reference
KEGG for taxonomy-based analysis of pathways and genomes
10.1093/nar/gkac963 · ExternalCitation · doi-reference
Homologous Recombination Deficiency: Concepts, Definitions, and Assays
10.1093/oncolo/oyab053 · ExternalCitation · doi-reference
CD44: a stemness driver, regulator, and marker—all in one?
10.1093/stmcls/sxae060 · ExternalCitation · doi-reference
Maftools: efficient and comprehensive analysis of somatic variants in cancer
10.1101/gr.239244.118 · ExternalCitation · doi-reference
AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells
10.1158/0008-5472.can-21-2342 · ExternalCitation · doi-reference
Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer
10.1158/1078-0432.ccr-15-2477 · ExternalCitation · doi-reference
Cells in the Polyaneuploid Cancer Cell State Are Prometastatic
10.1158/1541-7786.mcr-24-0689 · ExternalCitation · doi-reference
Lipogenesis promotes mitochondrial fusion and maintains cancer stemness in human NSCLC
10.1172/jci.insight.158429 · ExternalCitation · doi-reference
Increased HRD score in cisplatin resistant penile cancer cells
10.1186/s12885-022-10432-7 · ExternalCitation · doi-reference
Interleukin-17D promotes lung cancer progression by inducing tumor-associated macrophage infiltration via the p38 MAPK signaling pathway
10.18632/aging.204208 · ExternalCitation · doi-reference
Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation
10.3389/fcell.2024.1410637 · ExternalCitation · doi-reference
Repositioning of Hypoglycemic Drug Linagliptin for Cancer Treatment
10.3389/fphar.2020.00187 · ExternalCitation · doi-reference
Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted
10.3390/ijms23137241 · ExternalCitation · doi-reference
Intratumor Heterogeneity and Treatment Resistance of Solid Tumors with a Focus on Polyploid/Senescent Giant Cancer Cells (PGCCs)
10.3390/ijms241411534 · ExternalCitation · doi-reference
The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer
10.3390/ijms242115812 · ExternalCitation · doi-reference
Circulating Polyploid Giant Cancer Cells, a Potential Prognostic Marker in Patients with Carcinoma
10.3390/ijms25189841 · ExternalCitation · doi-reference
Construction of a cisplatin-induced polyploid giant cancer cell model
10.3969/j.issn.1004-616x.2024.06.010 · ExternalCitation · doi-reference
