Research graph
References from KIF18A inhibition enhances glioma response to radiotherapy through activation of cGAS–STING signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015–2019
2022 · External reference
Management of glioblastoma: State of the art and future directions
10.3322/caac.21613 · 2020 · External reference
Recurrence Pattern Analysis of Primary Glioblastoma
10.1016/j.wneu.2017.04.053 · 2017 · External reference
Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis
10.1007/s11060-017-2564-z · 2017 · External reference
Molecular mechanisms of tumor resistance to radiotherapy
2023 · External reference
Exploration of inhibitors targeting KIF18A with ploidy-specific lethality
10.1016/j.drudis.2024.104142 · 2024 · External reference
The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression
10.1016/j.cub.2007.02.036 · 2007 · External reference
The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment
10.1016/j.devcel.2007.11.014 · 2008 · External reference
Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores
10.1016/j.cub.2018.06.026 · 2018 · External reference
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma
2018 · External reference
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer
10.12659/msm.917352 · 2019 · External reference
Kif18A is involved in human breast carcinogenesis
10.1093/carcin/bgq134 · 2010 · External reference
Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma
10.1002/iub.2030 · 2019 · External reference
The Proliferation of Glioblastoma Is Contributed to Kinesin Family Member 18A and Medical Data Analysis of GBM
10.3389/fgene.2022.858882 · 2022 · External reference
KIF18A inhibition: the next big player in the search for cancer therapeutics
10.1007/s10555-024-10225-3 · 2024 · External reference
Genome doubling shapes the evolution and prognosis of advanced cancers
10.1038/s41588-018-0165-1 · 2018 · External reference
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
10.1038/s41586-020-03133-3 · 2021 · External reference
Chromosomally unstable tumor cells specifically require KIF18A for proliferation
10.1038/s41467-021-21447-2 · 2021 · External reference
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
10.1038/s41586-020-03114-6 · 2021 · External reference
Numerical chromosomal instability mediates susceptibility to radiation treatment
10.1038/ncomms6990 · 2015 · External reference
Chromosome Missegregation as a Modulator of Radiation Sensitivity
10.1016/j.semradonc.2021.09.002 · 2022 · External reference
Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers
10.1038/s43018-023-00699-5 · 2024 · External reference
Targeting chromosomally unstable tumors with a selective KIF18A inhibitor
10.1038/s41467-024-55300-z · 2025 · External reference
A designer peptide against the EAG2–Kvβ2 potassium channel targets the interaction of cancer cells and neurons to treat glioblastoma
10.1038/s43018-023-00626-8 · 2023 · External reference
Generation and biobanking of patient-derived glioblastoma organoids and their application in CAR T cell testing
10.1038/s41596-020-0402-9 · 2020 · External reference
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma
10.1016/j.cmet.2024.07.011 · 2024 · External reference
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
10.1038/ng.3984 · 2017 · External reference
Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma
2021 · External reference
Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response
10.1038/s41588-021-00926-8 · 2021 · External reference
Discovery and preclinical characterization of AMG 650, a first-in-class inhibitor of kinesin KIF18A motor protein with potent activity against chromosomally unstable cancers
10.1158/1538-7445.am2023-516 · 2023 · External reference
Human organoids: model systems for human biology and medicine
10.1038/s41580-020-0259-3 · 2020 · External reference
Organoids — Preclinical Models of Human Disease
10.1056/nejmra1806175 · 2019 · External reference
Unresolved reference
2002 · External reference
Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair
10.1038/s41388-021-01878-3 · 2021 · External reference
Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis
10.1083/jcb.202101165 · 2021 · External reference
The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer
10.1158/2159-8290.cd-19-0761 · 2020 · External reference
cGAS surveillance of micronuclei links genome instability to innate immunity
10.1038/nature23449 · 2017 · External reference
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer
10.1186/s12935-020-01191-1 · 2020 · External reference
Kinesin 18A expression: clinical relevance to colorectal cancer progression
10.1002/ijc.25916 · 2011 · External reference
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma
2014 · External reference
Comprehensive Pan-Cancer Analysis of KIF18A as a Marker for Prognosis and Immunity
2023 · External reference
Recurrence- and Malignant Progression-Associated Biomarkers in Low-Grade Gliomas and Their Roles in Immunotherapy
10.3389/fimmu.2022.899710 · 2022 · External reference
Prognostic Biomarker KIF18A and Its Correlations With Immune Infiltrates and Mitosis in Glioma
10.3389/fgene.2022.852049 · 2022 · External reference
Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells
10.18632/oncotarget.4613 · 2015 · External reference
Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective
10.1016/j.cell.2023.12.013 · 2024 · External reference
Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis
2022 · External reference
KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer
10.1016/j.bbrc.2021.04.020 · 2021 · External reference
BTB-1: A Small Molecule Inhibitor of the Mitotic Motor Protein Kif18A
10.1002/anie.200904510 · 2009 · External reference
Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe
10.1021/acs.jmedchem.1c02030 · 2022 · External reference
Discovery of potent, orally active KIF18A inhibitors targeting CIN-high cancer cells
2022 · External reference
Unresolved reference
2024 · External reference
Unresolved reference
External reference
Loss of JAK1 Function Causes G2/M Cell Cycle Defects Vulnerable to KIF18A Inhibition
10.1158/0008-5472.can-25-1423 · 2026 · External reference
Mitotic lethality prevents inflammation
10.1038/s41556-024-01529-1 · 2025 · External reference
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage
10.1038/s41556-024-01557-x · 2025 · External reference
From polyploidy to aneuploidy, genome instability and cancer
10.1038/nrm1276 · 2004 · External reference
Targeting KIF18A triggers antitumor immunity and enhances efficiency of PD-1 blockade in colorectal cancer with chromosomal instability phenotype
10.1038/s41420-025-02437-5 · 2025 · External reference
Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines
10.1016/j.mrgentox.2013.06.010 · 2013 · External reference
Proliferation of aneuploid human cells is limited by a p53-dependent mechanism
10.1083/jcb.200905057 · 2010 · External reference
Homing in on genomic instability as a therapeutic target in cancer
10.1038/s41467-021-23965-5 · 2021 · External reference
