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References from Biotransformation of indole to indigo and indirubin by engineered Komagataella phaffii expressing MaFMO from Methylophaga aminisulfidivorans SK1. Local targets link to admitted publications; unresolved targets remain external evidence.
An overview of microbial indigo-forming enzymes
10.1007/s00253-019-10292-5 · 2020 · External reference
Overview of indigo biosynthesis by flavin-containing monooxygenases: History, industrialization challenges, and strategies, Biotechnol
10.1016/j.biotechadv.2024.108374 · 2024 · External reference
A review of recent progress in the synthesis of bio-indigoids and their biologically assisted end-use applications
10.1016/j.dyepig.2020.108570 · 2020 · External reference
Pharmacological properties of indirubin and its derivatives
10.1016/j.biopha.2022.113112 · 2022 · External reference
Molecular mechanisms of indirubin and its derivatives: Novel anticancer molecules with their origin in traditional Chinese phytomedicine
10.1007/s00432-004-0579-8 · 2004 · External reference
Indirubins inhibit glycogen synthase kinase-3β and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease
10.1074/jbc.m002466200 · 2001 · External reference
GSK-3-selective inhibitors derived from Tyrian purple indirubins
10.1016/j.chembiol.2003.11.010 · 2003 · External reference
A microbial factory for bio-indigo synthesis: Demonstration of sustainable denim dyeing
10.1039/d5gc01293g · 2025 · External reference
Expression of naphthalene oxidation genes in Escherichia coli results in the biosynthesis of indigo
10.1126/science.6353574 · 1983 · External reference
Mutations of toluene-4-monooxygenase that alter regiospecificity of indole oxidation and lead to production of novel indigoid pigments
10.1128/aem.71.9.5476-5483.2005 · 2005 · External reference
Elucidating cysteine-assisted synthesis of indirubin by a flavin-containing monooxygenase
10.1021/acscatal.9b02613 · 2019 · External reference
Enhanced indirubin production in recombinant Escherichia coli harboring a flavin-containing monooxygenase gene by cysteine supplementation
10.1016/j.jbiotec.2012.08.015 · 2012 · External reference
Bio-indigo production in two different fermentation systems using recombinant Escherichia coli cells harboring a flavin-containing monooxygenase gene
10.1016/j.procbio.2010.10.018 · 2011 · External reference
Protein engineering of toluene ortho-monooxygenase of Burkholderia cepacia G4 for regiospecific hydroxylation of indole to form various indigoid compounds
10.1007/s00253-004-1698-z · 2005 · External reference
Indigo formation by microorganisms expressing styrene monooxygenase activity
10.1128/aem.63.11.4287-4291.1997 · 1997 · External reference
Enhancing indigo production by over-expression of the styrene monooxygenase in Pseudomonas putida
10.1007/s00284-016-1055-3 · 2016 · External reference
Indigo production by Escherichia coli carrying the phenol hydroxylase gene from Acinetobacter sp. strain ST-550 in a water–organic solvent two-phase system
10.1007/s00253-002-1187-1 · 2003 · External reference
Metabolic engineering of Saccharomyces cerevisiae for heterologous indigo biosynthesis via tryptophan flux redirection
10.1016/j.dyepig.2026.113822 · 2026 · External reference
A novel flavin-containing monooxygenase from Methylophaga sp. strain SK1 and its indigo synthesis in Escherichia coli
10.1016/s0006-291x(03)01087-8 · 2003 · External reference
Structure-based redesign of a self-sufficient flavin-containing monooxygenase towards indigo production
10.3390/ijms20246148 · 2019 · External reference
Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO)
10.1007/s00253-018-09579-w · 2019 · External reference
Metabolic engineering of Escherichia coli BL21(DE3) for efficient production of indigo using Methylophaga aminisulfidivorans flavin-containing monooxygenase
10.1016/j.dyepig.2025.112682 · 2025 · External reference
Enhancement of indigo production by metabolically engineered Escherichia coli MG1655 using membrane engineering and two-stage cultivation
10.1021/acs.jafc.5c01400 · 2025 · External reference
Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin
10.1186/s40643-022-00559-7 · 2022 · External reference
Characterization of a flavin-containing monooxygenase from Corynebacterium glutamicum and its application to production of indigo and indirubin
10.1007/s10529-015-1824-2 · 2015 · External reference
Heterologous protein expression in the methylotrophic yeast Pichia pastoris, FEMS Microbiol
10.1111/j.1574-6976.2000.tb00532.x · 2000 · External reference
Recombinant protein expression in Pichia pastoris
10.1385/mb:16:1:23 · 2000 · External reference
Komagataella phaffii as emerging model organism in fundamental research
10.3389/fmicb.2020.607028 · 2021 · External reference
Advances in cell engineering of the Komagataella phaffii platform for recombinant protein production
10.3390/metabo12040346 · 2022 · External reference
Current advances of Pichia pastoris as cell factories for production of recombinant proteins
10.3389/fmicb.2022.1059777 · 2022 · External reference
Isolation of an Acinetobacter sp. ST-550 which produces a high level of indigo in a water–organic solvent two-phase system containing high levels of indole
10.1007/s00253-001-0919-y · 2002 · External reference
Biodegradation and biotransformation of indole: Advances and perspectives
10.3389/fmicb.2018.02625 · 2018 · External reference
Application of metabolic engineering to improve both the production and use of biotech indigo
10.1038/sj.jim.7000228 · 2002 · External reference
PAOX1 expression in mixed-substrate continuous cultures of Komagataella phaffii (Pichia pastoris) is completely determined by methanol consumption regardless of the secondary carbon source
10.3389/fbioe.2023.1123703 · 2023 · External reference
Fed-batch high-cell-density fermentation strategies for Pichia pastoris growth and production
10.1080/07388551.2018.1554620 · 2019 · External reference
