Research graph
References from Regulatory Evolution of TEM β-lactamases through Large-Scale Genomic Analysis Reveals Promoter Diversity and its Impact on β-lactam Resistance in Escherichia coli. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular mechanisms of antibiotic resistance
10.1038/nrmicro3380 · 2015 · External reference
Origins and evolution of antibiotic resistance
10.1128/mmbr.00016-10 · 2010 · External reference
The regulation of bacterial transcription initiation
10.1038/nrmicro787 · 2004 · External reference
Bacterial sigma factors: a historical, structural, and genomic perspective
10.1146/annurev-micro-092412-155737 · 2014 · External reference
10.1038/35021219
10.1038/35021219 · 2000 · External reference
10.1038/s41579-019-0159-8
10.1038/s41579-019-0159-8 · 2019 · External reference
The structure of beta-lactamases
1980 · External reference
Updated functional classification of beta-lactamases
10.1128/aac.01009-09 · 2010 · External reference
10.1128/cmr.14.4.933-951.2001
10.1128/cmr.14.4.933-951.2001 · External reference
10.3389/fmolb.2018.00016
10.3389/fmolb.2018.00016 · 2018 · External reference
Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases
10.1016/j.ijantimicag.2021.106498 · 2022 · External reference
Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance
10.1111/j.1574-6976.2010.00222.x · 2010 · External reference
Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment
10.1016/j.sjbs.2014.08.002 · 2015 · External reference
10.1093/jacamr/dlab092
10.1093/jacamr/dlab092 · 2021 · External reference
10.1128/aac.01707-08
10.1128/aac.01707-08 · 2009 · External reference
10.1128/aac.49.3.1267-1268.2005
10.1128/aac.49.3.1267-1268.2005 · 2005 · External reference
Mobile Genetic Elements Associated with Antimicrobial Resistance
10.1128/cmr.00088-17 · 2018 · External reference
Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae
10.1093/jac/dkx488 · 2018 · External reference
P5 upstream from bla(TEM) genes and their relationship to beta-lactam resistance
10.1128/aac.46.12.4035-4037.2002 · 2002 · External reference
Piperacillin-Tazobactam (TZP) Resistance in Escherichia coli Due to Hyperproduction of TEM-1 β-Lactamase Mediated by the Promoter Pa/Pb
10.3389/fmicb.2019.00833 · 2019 · External reference
Gene sharing among plasmids and chromosomes reveals barriers for antibiotic resistance gene transfer
2022 · External reference
10.1093/ismejo/wrad032
10.1093/ismejo/wrad032 · 2024 · External reference
Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria
10.1038/s41467-024-45045-0 · 2024 · External reference
The Role of Integrative and Conjugative Elements in Antibiotic Resistance Evolution
10.1016/j.tim.2020.05.011 · 2021 · External reference
10.1128/mmbr.00119-22
10.1128/mmbr.00119-22 · 2024 · External reference
Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain
10.1128/aac.48.12.4873-4877.2004 · 2004 · External reference
Effect of bla regulators on the susceptible phenotype and phenotypic conversion for oxacillin-susceptible mecA-positive staphylococcal isolates
10.1093/jac/dkw123 · 2016 · External reference
10.1038/s41598-025-10760-1
10.1038/s41598-025-10760-1 · 2025 · External reference
10.1186/s12866-025-04394-6
10.1186/s12866-025-04394-6 · 2025 · External reference
10.3389/fmicb.2026.1842717
10.3389/fmicb.2026.1842717 · 2026 · External reference
10.1128/aac.01082-24
10.1128/aac.01082-24 · 2025 · External reference
Mobility of plasmids
10.1128/mmbr.00020-10 · 2010 · External reference
10.1111/1574-6976.12067
10.1111/1574-6976.12067 · 2014 · External reference
The organization of the bacterial genome
10.1146/annurev.genet.42.110807.091653 · 2008 · External reference
Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths
10.1371/journal.pgen.1000344 · 2009 · External reference
10.1128/aac.06393-11
10.1128/aac.06393-11 · 2012 · External reference
Genetic Environment of bla(TEM-1), bla(CTX-M-15), bla(CMY-42) and Characterization of Integrons of Escherichia coli Isolated From an Indian Urban Aquatic Environment
10.3389/fmicb.2018.00382 · 2018 · External reference
Complete nucleotide sequence of the Escherichia coli plasmid pBR322
10.1101/sqb.1979.043.01.013 · 1979 · External reference
10.1128/aac.43.2.367
10.1128/aac.43.2.367 · 1999 · External reference
Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria
10.1038/s41559-016-0010 · 2016 · External reference
Strength and regulation of the different promoters for chromosomal beta-lactamases of Klebsiella oxytoca
10.1128/aac.43.4.850 · 1999 · External reference
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322
10.1073/pnas.75.8.3737 · 1978 · External reference
10.1038/s41467-025-63714-6
10.1038/s41467-025-63714-6 · 2025 · External reference
Effect of hyperproduction of TEM-1 beta-lactamase on in vitro susceptibility of Escherichia coli to beta-lactam antibiotics
10.1128/aac.38.3.494 · 1994 · External reference
Mechanisms of hyperproduction of TEM-1 beta-lactamase by clinical isolates of Escherichia coli
10.1093/jac/36.6.927 · 1995 · External reference
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors
10.1128/aac.38.5.1085 · 1994 · External reference
A novel extended-spectrum TEM-type beta-lactamase (TEM-52) associated with decreased susceptibility to moxalactam in Klebsiella pneumoniae
10.1128/aac.42.1.108 · 1998 · External reference
10.1038/s41467-020-18668-2
10.1038/s41467-020-18668-2 · 2020 · External reference
10.3389/fvets.2021.636715
10.3389/fvets.2021.636715 · External reference
10.1099/00221287-137-12-2681
10.1099/00221287-137-12-2681 · 1991 · External reference
Unresolved reference
2238 · External reference
10.1038/s41467-026-74934-9
10.1038/s41467-026-74934-9 · 2026 · External reference
How Should We Study the Indirect Effects of Antimicrobial Treatment Strategies? A Causal Perspective
10.1097/ede.0000000000001921 · 2025 · External reference
Structure of the bacterial RNA polymerase promoter specificity sigma subunit
10.1016/s1097-2765(02)00470-7 · 2002 · External reference
Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4
10.1016/j.jmb.2007.06.081 · 2007 · External reference
6S RNA binding to Esigma(70) requires a positively charged surface of sigma(70) region 4.2
10.1111/j.1365-2958.2009.06758.x · 2009 · External reference
Unresolved reference
1989 · External reference
An intersubunit contact stimulating transcription initiation by E coli RNA polymerase: interaction of the alpha C-terminal domain and sigma region 4
10.1101/gad.1079403 · 2003 · External reference
Functional interaction between RNA polymerase alpha subunit C-terminal domain and sigma70 in UP-element- and activator-dependent transcription
10.1016/s1097-2765(03)00201-6 · 2003 · External reference
Interactions between activating region 3 of the Escherichia coli cyclic AMP receptor protein and region 4 of the RNA polymerase sigma(70) subunit: application of suppression genetics
10.1006/jmbi.2000.3737 · 2000 · External reference
Structural basis of transcription initiation
10.1126/science.1227786 · 2012 · External reference
Escherichia coli promoter opening and – 10 recognition: mutational analysis of sigma70
10.1093/emboj/19.5.1130 · 2000 · External reference
Aromatic amino acids in region 2.3 of Escherichia coli sigma 70 participate collectively in the formation of an RNA polymerase-promoter open complex
10.1006/jmbi.2000.3808 · 2000 · External reference
Unresolved reference
2008 · External reference
Unresolved reference
2009 · External reference
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10.1021/bi972041m · 1998 · External reference
Structural basis for promoter-10 element recognition by the bacterial RNA polymerase σ subunit
10.1016/j.cell.2011.10.041 · 2011 · External reference
Changes in conserved region 2 of Escherichia coli sigma 70 affecting promoter recognition
10.1016/s0022-2836(05)80345-6 · 1990 · External reference
10.1093/nar/gkac1003
10.1093/nar/gkac1003 · 2023 · External reference
Unresolved reference
External reference
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10.1093/nar/gkac920 · 2023 · External reference
10.1093/bioinformatics/btx433
10.1093/bioinformatics/btx433 · 2017 · External reference
10.25080/majora-92bf1922-00a
10.25080/majora-92bf1922-00a · 2010 · External reference
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Unresolved reference
2011 · External reference
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10.1017/cbo9780511803161 · 2009 · External reference
Unresolved reference
2023 · External reference
Unresolved reference
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10.1093/biomet/70.1.41 · 1983 · External reference
10.1093/biomet/87.3.706
10.1093/biomet/87.3.706 · 2000 · External reference
Cryo-EM structure of Escherichia coli σ(70) RNA polymerase and promoter DNA complex revealed a role of σ non-conserved region during the open complex formation
10.1074/jbc.ra118.002161 · 2018 · External reference
Unresolved reference
2025 · External reference
10.1021/acs.jctc.1c00302
10.1021/acs.jctc.1c00302 · 2021 · External reference
Interactions between activating region 3 of the Escherichia coli cyclic AMP receptor protein and region 4 of the RNA polymerase sigma(70) subunit: application of suppression genetics
10.1006/jmbi.2000.3737 · ExternalCitation · doi-reference
Aromatic amino acids in region 2.3 of Escherichia coli sigma 70 participate collectively in the formation of an RNA polymerase-promoter open complex
10.1006/jmbi.2000.3808 · ExternalCitation · doi-reference
Structural basis for promoter-10 element recognition by the bacterial RNA polymerase σ subunit
10.1016/j.cell.2011.10.041 · ExternalCitation · doi-reference
Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases
10.1016/j.ijantimicag.2021.106498 · ExternalCitation · doi-reference
Crystal structure of the Escherichia coli regulator of sigma70, Rsd, in complex with sigma70 domain 4
10.1016/j.jmb.2007.06.081 · ExternalCitation · doi-reference
Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment
10.1016/j.sjbs.2014.08.002 · ExternalCitation · doi-reference
The Role of Integrative and Conjugative Elements in Antibiotic Resistance Evolution
10.1016/j.tim.2020.05.011 · ExternalCitation · doi-reference
Changes in conserved region 2 of Escherichia coli sigma 70 affecting promoter recognition
10.1016/s0022-2836(05)80345-6 · ExternalCitation · doi-reference
Structure of the bacterial RNA polymerase promoter specificity sigma subunit
10.1016/s1097-2765(02)00470-7 · ExternalCitation · doi-reference
Functional interaction between RNA polymerase alpha subunit C-terminal domain and sigma70 in UP-element- and activator-dependent transcription
10.1016/s1097-2765(03)00201-6 · ExternalCitation · doi-reference
10.1017/cbo9780511803161
10.1017/cbo9780511803161 · ExternalCitation · doi-reference
10.1021/acs.jctc.1c00302
10.1021/acs.jctc.1c00302 · ExternalCitation · doi-reference
10.1021/bi972041m
10.1021/bi972041m · ExternalCitation · doi-reference
10.1038/35021219
10.1038/35021219 · ExternalCitation · doi-reference
Molecular mechanisms of antibiotic resistance
10.1038/nrmicro3380 · ExternalCitation · doi-reference
The regulation of bacterial transcription initiation
10.1038/nrmicro787 · ExternalCitation · doi-reference
10.1038/s41467-020-18668-2
10.1038/s41467-020-18668-2 · ExternalCitation · doi-reference
Plasmid-mediated phenotypic noise leads to transient antibiotic resistance in bacteria
10.1038/s41467-024-45045-0 · ExternalCitation · doi-reference
10.1038/s41467-025-63714-6
10.1038/s41467-025-63714-6 · ExternalCitation · doi-reference
10.1038/s41467-026-74934-9
10.1038/s41467-026-74934-9 · ExternalCitation · doi-reference
Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria
10.1038/s41559-016-0010 · ExternalCitation · doi-reference
10.1038/s41579-019-0159-8
10.1038/s41579-019-0159-8 · ExternalCitation · doi-reference
10.1038/s41586-020-2649-2
10.1038/s41586-020-2649-2 · ExternalCitation · doi-reference
10.1038/s41598-025-10760-1
10.1038/s41598-025-10760-1 · ExternalCitation · doi-reference
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322
10.1073/pnas.75.8.3737 · ExternalCitation · doi-reference
Cryo-EM structure of Escherichia coli σ(70) RNA polymerase and promoter DNA complex revealed a role of σ non-conserved region during the open complex formation
10.1074/jbc.ra118.002161 · ExternalCitation · doi-reference
10.1093/bioinformatics/btx433
10.1093/bioinformatics/btx433 · ExternalCitation · doi-reference
10.1093/biomet/70.1.41
10.1093/biomet/70.1.41 · ExternalCitation · doi-reference
10.1093/biomet/87.3.706
10.1093/biomet/87.3.706 · ExternalCitation · doi-reference
Escherichia coli promoter opening and – 10 recognition: mutational analysis of sigma70
10.1093/emboj/19.5.1130 · ExternalCitation · doi-reference
10.1093/ismejo/wrad032
10.1093/ismejo/wrad032 · ExternalCitation · doi-reference
Mechanisms of hyperproduction of TEM-1 beta-lactamase by clinical isolates of Escherichia coli
10.1093/jac/36.6.927 · ExternalCitation · doi-reference
Effect of bla regulators on the susceptible phenotype and phenotypic conversion for oxacillin-susceptible mecA-positive staphylococcal isolates
10.1093/jac/dkw123 · ExternalCitation · doi-reference
Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae
10.1093/jac/dkx488 · ExternalCitation · doi-reference
10.1093/jacamr/dlab092
10.1093/jacamr/dlab092 · ExternalCitation · doi-reference
10.1093/nar/gkac1003
10.1093/nar/gkac1003 · ExternalCitation · doi-reference
CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
10.1093/nar/gkac920 · ExternalCitation · doi-reference
How Should We Study the Indirect Effects of Antimicrobial Treatment Strategies? A Causal Perspective
10.1097/ede.0000000000001921 · ExternalCitation · doi-reference
10.1099/00221287-137-12-2681
10.1099/00221287-137-12-2681 · ExternalCitation · doi-reference
An intersubunit contact stimulating transcription initiation by E coli RNA polymerase: interaction of the alpha C-terminal domain and sigma region 4
10.1101/gad.1079403 · ExternalCitation · doi-reference
Complete nucleotide sequence of the Escherichia coli plasmid pBR322
10.1101/sqb.1979.043.01.013 · ExternalCitation · doi-reference
10.1111/1574-6976.12067
10.1111/1574-6976.12067 · ExternalCitation · doi-reference
6S RNA binding to Esigma(70) requires a positively charged surface of sigma(70) region 4.2
10.1111/j.1365-2958.2009.06758.x · ExternalCitation · doi-reference
Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance
10.1111/j.1574-6976.2010.00222.x · ExternalCitation · doi-reference
Structural basis of transcription initiation
10.1126/science.1227786 · ExternalCitation · doi-reference
Updated functional classification of beta-lactamases
10.1128/aac.01009-09 · ExternalCitation · doi-reference
10.1128/aac.01082-24
10.1128/aac.01082-24 · ExternalCitation · doi-reference
10.1128/aac.01707-08
10.1128/aac.01707-08 · ExternalCitation · doi-reference
10.1128/aac.06393-11
10.1128/aac.06393-11 · ExternalCitation · doi-reference
Effect of hyperproduction of TEM-1 beta-lactamase on in vitro susceptibility of Escherichia coli to beta-lactam antibiotics
10.1128/aac.38.3.494 · ExternalCitation · doi-reference
Emergence of clinical isolates of Escherichia coli producing TEM-1 derivatives or an OXA-1 beta-lactamase conferring resistance to beta-lactamase inhibitors
10.1128/aac.38.5.1085 · ExternalCitation · doi-reference
A novel extended-spectrum TEM-type beta-lactamase (TEM-52) associated with decreased susceptibility to moxalactam in Klebsiella pneumoniae
10.1128/aac.42.1.108 · ExternalCitation · doi-reference
10.1128/aac.43.2.367
10.1128/aac.43.2.367 · ExternalCitation · doi-reference
Strength and regulation of the different promoters for chromosomal beta-lactamases of Klebsiella oxytoca
10.1128/aac.43.4.850 · ExternalCitation · doi-reference
P5 upstream from bla(TEM) genes and their relationship to beta-lactam resistance
10.1128/aac.46.12.4035-4037.2002 · ExternalCitation · doi-reference
Beta-lactamase gene expression in a penicillin-resistant Bacillus anthracis strain
10.1128/aac.48.12.4873-4877.2004 · ExternalCitation · doi-reference
10.1128/aac.49.3.1267-1268.2005
10.1128/aac.49.3.1267-1268.2005 · ExternalCitation · doi-reference
Mobile Genetic Elements Associated with Antimicrobial Resistance
10.1128/cmr.00088-17 · ExternalCitation · doi-reference
10.1128/cmr.14.4.933-951.2001
10.1128/cmr.14.4.933-951.2001 · ExternalCitation · doi-reference
Origins and evolution of antibiotic resistance
10.1128/mmbr.00016-10 · ExternalCitation · doi-reference
Mobility of plasmids
10.1128/mmbr.00020-10 · ExternalCitation · doi-reference
10.1128/mmbr.00119-22
10.1128/mmbr.00119-22 · ExternalCitation · doi-reference
Bacterial sigma factors: a historical, structural, and genomic perspective
10.1146/annurev-micro-092412-155737 · ExternalCitation · doi-reference
The organization of the bacterial genome
10.1146/annurev.genet.42.110807.091653 · ExternalCitation · doi-reference
10.1186/s12866-025-04394-6
10.1186/s12866-025-04394-6 · ExternalCitation · doi-reference
Organised genome dynamics in the Escherichia coli species results in highly diverse adaptive paths
10.1371/journal.pgen.1000344 · ExternalCitation · doi-reference
10.25080/majora-92bf1922-00a
10.25080/majora-92bf1922-00a · ExternalCitation · doi-reference
Genetic Environment of bla(TEM-1), bla(CTX-M-15), bla(CMY-42) and Characterization of Integrons of Escherichia coli Isolated From an Indian Urban Aquatic Environment
10.3389/fmicb.2018.00382 · ExternalCitation · doi-reference
Piperacillin-Tazobactam (TZP) Resistance in Escherichia coli Due to Hyperproduction of TEM-1 β-Lactamase Mediated by the Promoter Pa/Pb
10.3389/fmicb.2019.00833 · ExternalCitation · doi-reference
10.3389/fmicb.2026.1842717
10.3389/fmicb.2026.1842717 · ExternalCitation · doi-reference
10.3389/fmolb.2018.00016
10.3389/fmolb.2018.00016 · ExternalCitation · doi-reference
10.3389/fvets.2021.636715
10.3389/fvets.2021.636715 · ExternalCitation · doi-reference
