Research graph
References from Full-length transcriptome and light-regulated analyses identify candidate genes involved in rhynchophylline and isorhynchophylline biosynthesis in Uncaria rhynchophylla. Local targets link to admitted publications; unresolved targets remain external evidence.
Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus
10.1007/s00709-018-1233-1 · 2018 · External reference
10.1073/pnas.1504951112
10.1073/pnas.1504951112 · 2015 · External reference
10.1104/pp.113.222828
10.1104/pp.113.222828 · External reference
10.1038/s44319-023-00030-4 · 2024 · Admitted local publication
The functions of long noncoding RNAs in plants
10.1016/j.pbi.2025.102830 · 2026 · External reference
Roles of chorismate mutase, isochorismate synthase and anthranilate synthase in plants
10.1016/0031-9422(91)83688-h · 1991 · External reference
Unresolved reference
2025 · External reference
Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis
10.1016/s0014-5793(01)03045-9 · 2001 · External reference
10.1155/2008/619832
10.1155/2008/619832 · 2008 · External reference
A look inside an alkaloid multisite plant: the Catharanthus logistics
10.1016/j.pbi.2014.03.010 · 2014 · External reference
Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila
10.1038/srep08227 · 2015 · External reference
SMRT- and Illumina-based RNA-seq analyses unveil the ginsinoside biosynthesis and transcriptomic complexity in Panax notoginseng
10.1038/s41598-020-72291-1 · 2020 · External reference
10.1073/pnas.1121374109
10.1073/pnas.1121374109 · 2012 · External reference
Functions of ABC transporters in plant growth and development
10.1016/j.pbi.2017.08.003 · 2018 · External reference
CrBPF1 overexpression alters transcript levels of terpenoid indole alkaloid biosynthetic and regulatory genes
10.3389/fpls.2015.00818 · 2015 · External reference
Research progress on the biosynthesis and metabolic engineering of the anti-cancer drug camptothecin in Camptotheca acuminate
10.1016/j.indcrop.2022.115270 · 2022 · External reference
Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus
10.1074/jbc.275.5.3051 · 2000 · External reference
Transcriptome-wide identification, characterization, and phylogenomic analysis of cytochrome P450s from Nothapodytes nimmoniana reveal candidate genes involved in the camptothecin biosynthetic pathway
10.1139/gen-2020-0067 · 2020 · External reference
Interplay of transcription factors orchestrating the biosynthesis of plant alkaloids
10.1007/s13205-022-03316-x · 2022 · External reference
The subcellular organization of strictosidine biosynthesis in Catharanthus roseus epidermis highlights several trans-tonoplast translocations of intermediate metabolites
10.1111/j.1742-4658.2010.07994.x · 2011 · External reference
De novo transcriptome sequencing and digital gene expression analysis predict biosynthetic pathway of rhynchophylline and isorhynchophylline from Uncaria rhynchophylla, a non-model plant with potent anti-alzheimer's properties
10.1186/1471-2164-15-676 · 2014 · External reference
New zwitterionic monoterpene indole alkaloids from Uncaria rhynchophylla
10.1016/j.fitote.2018.01.013 · 2018 · External reference
Haploid-Phased Chromosomal Telomere-to-Telomere Genome Assembly of Medicinal Plant Uncaria rhynchophylla Dissects Genetic Controls on the Biosynthesis of Bioactive Alkaloids
10.1111/pce.15257 · 2024 · External reference
Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine
10.1016/j.ymben.2004.03.002 · 2004 · External reference
Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P450 CYP72A1 as secologanin synthase
10.1046/j.1365-313x.2000.00922.x · 2000 · External reference
10.1073/pnas.0911451107
10.1073/pnas.0911451107 · 2010 · External reference
The leaf epidermome of Catharanthus roseus reveals its biochemical specialization
10.1105/tpc.107.056630 · 2008 · External reference
The seco-iridoid pathway from Catharanthus roseus
10.1038/ncomms4606 · 2014 · External reference
A 7-deoxyloganetic acid glucosyltransferase contributes a key step in secologanin biosynthesis in Madagascar periwinkle
10.1105/tpc.113.115154 · 2013 · External reference
Hybrid error correction and de novo assembly of single-molecule sequencing reads
10.1038/nbt.2280 · 2012 · External reference
Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis
10.1186/s12870-019-1809-8 · 2019 · External reference
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
10.1186/1471-2105-12-323 · 2011 · External reference
The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway
10.1186/1471-2229-13-155 · 2013 · External reference
Isorhynchophylline ameliorates cognitive impairment via modulating amyloid pathology, tau hyperphosphorylation and neuroinflammation: Studies in a transgenic mouse model of Alzheimer’s disease
10.1016/j.bbi.2019.08.194 · 2019 · External reference
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
10.1093/bioinformatics/btl158 · 2006 · External reference
10.27047/d.cnki.ggudu.2022.002971
10.27047/d.cnki.ggudu.2022.002971 · 2022 · External reference
Uncarialins A-I, Monoterpenoid Indole Alkaloids from Uncaria rhynchophylla as Natural Agonists of the 5-HT1A Receptor
10.1021/acs.jnatprod.9b00532 · 2019 · External reference
Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering
10.1007/s10529-021-03179-x · 2021 · External reference
The cell and developmental biology of alkaloid biosynthesis
10.1016/s1360-1385(00)01575-2 · 2000 · External reference
The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins
10.1105/tpc.105.038018 · 2006 · External reference
10.1073/pnas.0812512106
10.1073/pnas.0812512106 · 2009 · External reference
RNA directed DNA methylation and seed plant genome evolution
10.1007/s00299-020-02558-4 · 2020 · External reference
Diversification of P450 Genes During Land Plant Evolution
10.1146/annurev-arplant-042809-112305 · 2010 · External reference
A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies
10.1016/j.fitote.2013.01.018 · 2013 · External reference
10.1073/pnas.0134257100
10.1073/pnas.0134257100 · 2003 · External reference
Long read sequencing to reveal the full complexity of a plant transcriptome by targeting both standard and long workflows
10.1186/s13007-023-01091-1 · 2023 · External reference
A simple and rapid HPLC-DAD method for simultaneously monitoring the accumulation of alkaloids and precursors in different parts and different developmental stages of Catharanthus roseus plants
10.1016/j.jchromb.2016.01.034 · 2016 · External reference
10.3389/fpls.2021.758202
10.3389/fpls.2021.758202 · External reference
Unresolved reference
2023 · External reference
Erratum to: The advantages of SMRT sequencing
10.1186/s13059-017-1295-y · 2017 · External reference
Environmental perception and epigenetic memory: mechanistic insight through FLC
10.1111/tpj.12869 · 2015 · External reference
Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats
10.1007/s11064-015-1730-y · 2015 · External reference
10.1007/978-1-4939-8546-3_9
10.1007/978-1-4939-8546-3_9 · 2018 · External reference
Characterization of Coptis japonica CjABCB2, an ATP-binding cassette protein involved in alkaloid transport
10.1016/j.phytochem.2012.02.012 · 2013 · External reference
BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs
10.1093/bioinformatics/btv351 · 2015 · External reference
Homology modelling and docking studies of strictosidine β-D-glucosidase from Madagascar periwinkle (Catharanthus roseus Bunge)
10.1504/ijbra.2022.10033607 · 2022 · External reference
A multidrug and toxic compound extrusion transporter mediates berberine accumulation into vacuoles in Coptis japonica
10.1016/j.phytochem.2017.03.003 · 2017 · External reference
Multidrug and toxic compound extrusion-type transporters implicated in vacuolar sequestration of nicotine in tobacco roots
10.1104/pp.108.132811 · 2009 · External reference
10.1271/bbb.100175
10.1271/bbb.100175 · 2010 · External reference
10.27047/d.cnki.ggudu.2022.000006
10.27047/d.cnki.ggudu.2022.000006 · 2022 · External reference
10.1073/pnas.1409457111
10.1073/pnas.1409457111 · 2014 · External reference
Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β-amyloid-toxicity
10.1111/nan.12647 · 2020 · External reference
Unresolved reference
2015 · External reference
Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures
10.1023/a:1010650906695 · 2001 · External reference
Profiles of Metabolic Genes in Uncaria rhynchophylla and Characterization of the Critical Enzyme Involved in the Biosynthesis of Bioactive Compounds-(iso)Rhynchophylline
10.3390/biom12121790 · 2022 · External reference
Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions
10.2174/1570161117666190704092841 · 2020 · External reference
A global survey of full-length transcriptome of Ginkgo biloba reveals transcript variants involved in flavonoid biosynthesis
10.1016/j.indcrop.2019.111547 · 2019 · External reference
10.1073/pnas.1307504110
10.1073/pnas.1307504110 · 2013 · External reference
Terpenoid indole alkaloid profile changes in Catharanthus pusillus during development
10.1016/s0168-9452(01)00340-5 · 2001 · External reference
10.1155/2019/4016323
10.1155/2019/4016323 · 2019 · External reference
Medicinal uses, phytochemistry and pharmacology of the genus Uncaria
10.1016/j.jep.2015.06.011 · 2015 · External reference
Genome-wide analysis and functional annotation of chromatin-enriched noncoding RNAs in rice during somatic cell regeneration
10.1186/s13059-022-02608-y · 2022 · External reference
Full-length transcriptome analysis of Coptis deltoidea and identification of putative genes involved in benzylisoquinoline alkaloids biosynthesis based on combined sequencing platforms
10.1007/s11103-019-00959-y · 2020 · External reference
Antihypertensive and neuroprotective activities of rhynchophylline: The role of rhynchophylline in neurotransmission and ion channel activity
10.1016/j.jep.2010.08.041 · 2010 · External reference
