Research graph
References from SUMO inhibition reveals temporally distinct intron retention programs shaping the immunopeptidome in acute myeloid leukemia. Local targets link to admitted publications; unresolved targets remain external evidence.
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
10.1182/blood-2016-08-733196 · 2017 · External reference
Unresolved reference
2019 · External reference
Current status and research directions in acute myeloid leukemia
10.1038/s41408-024-01143-2 · 2024 · External reference
Prevention and Treatment of Acute Myeloid Leukemia Relapse after Hematopoietic Stem Cell Transplantation: The State of the Art and Future Perspectives
10.3390/jcm11010253 · 2022 · External reference
Acute myeloid leukemia in the elderly: do we know who should be treated and how?
10.3109/10428194.2013.828348 · 2014 · External reference
Challenges in GVHD and GVL after hematopoietic stem cell transplantation for myeloid malignancies
10.1182/blood.2025028617 · 2025 · External reference
Neoantigen reactive T cells correlate with the low mutational burden in hematological malignancies
10.1038/s41375-022-01705-y · 2022 · External reference
Immune checkpoint-based therapy in myeloid malignancies: a promise yet to be fulfilled
10.1080/14737140.2019.1589374 · 2019 · External reference
Mosquera Orgueira, A. Immune Checkpoint Inhibitors in Acute Myeloid Leukemia: A Meta-Analysis
10.3389/fonc.2022.882531 · 2022 · External reference
Immune checkpoints regulate acute myeloid leukemia stem cells
10.1038/s41375-025-02566-x · 2025 · External reference
Regulation and Function of the PD-L1 Checkpoint
10.1016/j.immuni.2018.03.014 · 2018 · External reference
Hypomethylating agents in combination with immune checkpoint inhibitors in acute myeloid leukemia and myelodysplastic syndromes
10.1038/s41375-018-0070-8 · 2018 · External reference
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
10.1016/j.immuni.2021.03.001 · 2021 · External reference
The SUMO Pathway in Hematomalignancies and Their Response to Therapies
10.3390/ijms20163895 · 2019 · External reference
The post-translational modification, SUMOylation, and cancer (Review)
2018 · External reference
Immune regulation by the SUMO family
2025 · External reference
Signalling mechanisms and cellular functions of SUMO
10.1038/s41580-022-00500-y · 2022 · External reference
When SUMO met splicing
2018 · External reference
The ROS/SUMO axis contributes to the response of acute myeloid leukemia cells to chemotherapeutic drugs
10.1016/j.celrep.2014.05.016 · 2014 · External reference
Hyper-SUMOylation of ERG Is Essential for the Progression of Acute Myeloid Leukemia
10.3389/fmolb.2021.652284 · 2021 · External reference
Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer
10.1021/acs.jmedchem.0c01491 · 2021 · External reference
TAK-981, a SUMOylation inhibitor, suppresses AML growth immune-independently
10.1182/bloodadvances.2022007956 · 2023 · External reference
A new immuno-oncology target - SUMOylation
10.1016/j.trecan.2023.04.010 · 2023 · External reference
SUMOylation inhibitor TAK-981 (subasumstat) synergizes with 5-azacytidine in preclinical models of acute myeloid leukemia
10.3324/haematol.2023.282704 · 2024 · External reference
T Cell-intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
10.1158/1535-7163.mct-22-0762 · 2023 · External reference
A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
10.1126/scitranslmed.aba7791 · 2021 · External reference
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing
10.1093/nar/gkx213 · 2017 · External reference
Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome
10.1016/j.immuni.2026.02.005 · 2026 · External reference
Translation dysregulation in cancer as a source for targetable antigens
10.1016/j.ccell.2025.03.003 · 2025 · External reference
Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer
10.1038/s43018-025-00979-2 · 2025 · External reference
BamQuery: a proteogenomic tool to explore the immunopeptidome and prioritize actionable tumor antigens
10.1186/s13059-023-03029-1 · 2023 · External reference
SpliceWiz: interactive analysis and visualization of alternative splicing in R
2023 · External reference
J. The changing paradigm of intron retention: regulation, ramifications and recipes
2019 · External reference
Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer
10.1186/s13046-024-02986-0 · 2024 · External reference
Site-specific characterization of endogenous SUMOylation across species and organs
10.1038/s41467-018-04957-4 · 2018 · External reference
Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling
10.1038/ncomms6409 · 2014 · External reference
Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility
10.1038/s41467-020-14581-w · 2020 · External reference
Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency
2024 · External reference
The pioneer round of translation: features and functions
10.1016/j.cell.2010.07.022 · 2010 · External reference
Pioneer translation products as an alternative source for MHC-I antigenic peptides
10.1016/j.molimm.2015.04.019 · 2015 · External reference
Pan-cancer analysis of the prognostic significance of ACKR2 expression and the related genetic/epigenetic dysregulations
10.1080/1744666x.2023.2274361 · 2024 · External reference
Intron Retention: A Reemerging Paradigm in RNA Biology and Post-Transcriptional Gene Regulation
2025 · External reference
Widespread intron retention diversifies most cancer transcriptomes
10.1186/s13073-015-0168-9 · 2015 · External reference
Intron retention is a source of neoepitopes in cancer
10.1038/nbt.4239 · 2018 · External reference
The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I-Associated Peptides
10.1158/2326-6066.cir-22-0621 · 2023 · External reference
Noncanonical Transcription and Splicing Shape the Colorectal Cancer Immunopeptidome in MSI and MSS Tumors
10.1016/j.mcpro.2026.101581 · 2026 · External reference
Immunogenic cryptic peptides dominate the antigenic landscape of ovarian cancer
10.1126/sciadv.ads7405 · 2025 · External reference
Expanding the human proteome with microproteins and peptideins
10.1038/s41586-026-10459-x · 2026 · External reference
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
10.1038/s41587-020-00806-2 · 2021 · External reference
The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation
10.1038/s41388-018-0281-5 · 2018 · External reference
TRIM28-mediated SUMOylation of G3BP1/2 regulates stress granule dynamics
10.1016/j.chembiol.2025.10.003 · 2025 · External reference
Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation
10.1016/j.immuni.2012.12.004 · 2013 · External reference
A First-In-Human Study of the SUMOylation Inhibitor Subasumstat in Patients with Advanced/Metastatic Solid Tumors or Relapsed/Refractory Hematologic Malignancies
10.1158/2767-9764.crc-25-0243 · 2025 · External reference
Trimmomatic: a flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Near-optimal probabilistic RNA-seq quantification
10.1038/nbt.3519 · 2016 · External reference
OptiType: precision HLA typing from next-generation sequencing data
10.1093/bioinformatics/btu548 · 2014 · External reference
The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads
10.1093/nar/gkz114 · 2019 · External reference
voom: Precision weights unlock linear model analysis tools for RNA-seq read counts
10.1186/gb-2014-15-2-r29 · 2014 · External reference
limma powers differential expression analyses for RNA-sequencing and microarray studies
10.1093/nar/gkv007 · 2015 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest
10.1093/nar/gkac1000 · 2023 · External reference
Cytoscape: a software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
Making genome-scale phylogenetics accessible to all
10.1002/pro.4218 · 2022 · External reference
Noncoding regions are the main source of targetable tumor-specific antigens
10.1126/scitranslmed.aau5516 · 2018 · External reference
Unresolved reference
2012 · External reference
Unresolved reference
2016 · External reference
Comparison of the MHC I Immunopeptidome Repertoire of B-Cell Lymphoblasts Using Two Isolation Methods
10.1002/pmic.201700251 · 2018 · External reference
Unresolved reference
2012 · External reference
A Cloud-Based Computational Platform for Immunopeptidomics Analyses
10.1021/acs.jproteome.9b00859 · 2020 · External reference
NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data
10.1093/nar/gkaa379 · 2020 · External reference
DEP2: an upgraded comprehensive analysis toolkit for quantitative proteomics data
10.1093/bioinformatics/btad526 · 2023 · External reference
Mfuzz: a software package for soft clustering of microarray data
10.6026/97320630002005 · 2007 · External reference
A simple and fast method to determine the parameters for fuzzy c-means cluster analysis
10.1093/bioinformatics/btq534 · 2010 · External reference
Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning
10.1038/s41592-019-0426-7 · 2019 · External reference
DeepLC can predict retention times for peptides that carry as-yet unseen modifications
10.1038/s41592-021-01301-5 · 2021 · External reference
Improved predictions of antigen presentation and TCR recognition with MixMHCpred2.2 and PRIME2.0 reveal potent SARS-CoV-2 CD8(+) T-cell epitopes
10.1016/j.cels.2022.12.002 · 2023 · External reference
Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals
10.1089/1066527041410418 · 2004 · External reference
karyoploteR: an R/Bioconductor package to plot customizable genomes displaying arbitrary data
10.1093/bioinformatics/btx346 · 2017 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
The ProteomeXchange consortium in 2020: enabling 'big data' approaches in proteomics
2020 · External reference
The PRIDE database and related tools and resources in 2019: improving support for quantification data
10.1093/nar/gky1106 · 2019 · External reference
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
