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References from Building a clinical platform for response-guided geroscience: safety and feasibility in the randomized ELITE pilot trial. Local targets link to admitted publications; unresolved targets remain external evidence.
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Geroscience: linking aging to chronic disease
10.1016/j.cell.2014.10.039 · 2014 · External reference
Challenges in developing geroscience trials
10.1038/s41467-023-39786-7 · 2023 · External reference
Personal aging markers and ageotypes revealed by deep longitudinal profiling
10.1038/s41591-019-0719-5 · 2020 · External reference
Wearable devices in clinical trials: hype and hypothesis
10.1002/cpt.966 · 2018 · External reference
Bayesian clinical trials
10.1038/nrd1927 · 2006 · External reference
Single-patient (n-of-1) trials: a pragmatic clinical decision methodology for patient-centered comparative effectiveness research
10.1016/j.jclinepi.2013.04.006 · 2013 · External reference
Digital twins for health: a scoping review
10.1038/s41746-024-01073-0 · 2024 · External reference
Unresolved reference
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Metformin as a tool to target aging
10.1016/j.cmet.2016.05.011 · 2016 · External reference
Semaglutide and cardiovascular outcomes in obesity without diabetes
10.1056/nejmoa2307563 · 2023 · External reference
Empagliflozin in patients with chronic kidney disease
10.1056/nejmoa2204233 · 2023 · External reference
Metabolic flexibility as an adaptation to energy resources and requirements in health and disease
10.1210/er.2017-00211 · 2018 · External reference
Network physiology: how organ systems dynamically interact
10.1371/journal.pone.0142143 · 2015 · External reference
Mitochondrial psychobiology: foundations and applications
10.1016/j.cobeha.2019.04.015 · 2019 · External reference
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CONSORT 2025 statement: updated guideline for reporting randomised trials
10.1136/bmj-2024-081123 · 2025 · External reference
CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials
10.1136/bmj-2024-081124 · 2025 · External reference
CONSORT 2010 statement: extension to randomised pilot and feasibility trials
10.1136/bmj.i5239 · 2016 · External reference
Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI extension
10.1038/s41591-020-1034-x · 2020 · External reference
Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension
10.1038/s41591-020-1037-7 · 2020 · External reference
Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide
10.1136/bmj.g1687 · 2014 · External reference
CONSORT Harms 2022 statement, explanation, and elaboration: updated guideline for the reporting of harms in randomised trials
10.1136/bmj-2022-073725 · 2023 · External reference
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2010 · External reference
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2024 · External reference
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2023 · External reference
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AI-enabled optimization of early-phase clinical trials pilot program; request for information
2026 · External reference
Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults
10.1111/acel.12723 · 2018 · External reference
Antecedent Metabolic Health and Metformin (ANTHEM) Aging Study: rationale and study design for a randomized controlled trial
10.1093/gerona/glab358 · 2022 · External reference
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
10.1186/s12979-023-00343-x · 2023 · External reference
Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy
10.1038/s41467-026-72861-3 · 2026 · External reference
Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results
10.18632/aging.206235 · 2025 · External reference
Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
10.2337/dc13-2105 · 2014 · External reference
Effect of semaglutide on the pharmacokinetics of metformin, warfarin, atorvastatin and digoxin in healthy subjects
10.1007/s40262-017-0532-6 · 2017 · External reference
Pharmacokinetics of empagliflozin, a sodium glucose cotransporter-2 (SGLT2) inhibitor, and metformin following co-administration in healthy volunteers
10.5414/cp201794 · 2013 · External reference
Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial
10.1016/j.eclinm.2026.103874 · 2026 · External reference