Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Dual Modulation of Prostaglandin E2 Receptors EP3 and EP4 Protects β-Cell Mass in a Model of Aggressive Autoimmune Inflammation. Local targets link to admitted publications; unresolved targets remain external evidence.
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited
10.2337/db10-1797 · 2011 · External reference
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
10.1016/j.celrep.2025.116174 · 2025 · External reference
The role of beta-cell dysfunction in early type 1 diabetes
10.1097/med.0000000000000548 · 2020 · External reference
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells
10.2337/db08-0178 · 2009 · External reference
Oxidative stress leads to β-cell dysfunction through loss of β-cell identity
10.3389/fimmu.2021.690379 · 2021 · External reference
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
10.1038/ncb1909 · 2009 · External reference
Targeted elimination of senescent beta cells prevents type 1 diabetes
10.1016/j.cmet.2019.01.021 · 2019 · External reference
Acceleration of β cell aging determines diabetes and senolysis improves disease outcomes
10.1016/j.cmet.2019.05.006 · 2019 · External reference
Prostaglandin E2-induced inflammation: relevance of prostaglandin E receptors
10.1016/j.bbalip.2014.07.008 · 2015 · External reference
Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion
10.2337/db12-0769 · 2013 · External reference
Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation
10.1016/j.molmet.2017.04.002 · 2017 · External reference
Pharmacological blockade of the EP3 prostaglandin E2 receptor in the setting of type 2 diabetes enhances β-cell proliferation and identity and relieves oxidative damage
10.1016/j.molmet.2021.101347 · 2021 · External reference
Effects of arachidonic acid and its metabolites on functional beta-cell mass
10.3390/metabo12040342 · 2022 · External reference
Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome
10.1210/me.2012-1176 · 2012 · External reference
The inhibitory G protein α-subunit, Gαz, promotes type 1 diabetes-like pathophysiology in NOD mice
10.1210/en.2016-1700 · 2017 · External reference
PTGS-2-PTGER2/4 signaling pathway partially protects from diabetogenic toxicity of streptozotocin in mice
10.2337/db11-1396 · 2012 · External reference
Harnessing prostaglandin E2 signaling to ameliorate autoimmunity
10.1016/j.it.2023.01.004 · 2023 · External reference
Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases
10.1093/intimm/dxz021 · 2019 · External reference
Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase
10.1038/ncomms2684 · 2013 · External reference
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling
10.1084/jem.20082293 · 2009 · External reference
PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway
10.4049/jimmunol.1202462 · 2013 · External reference
Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells
10.4049/jimmunol.175.3.1483 · 2005 · External reference
Cyclophosphamide-induced diabetes in NOD/WEHI mice. Evidence for suppression in spontaneous autoimmune diabetes mellitus
10.2337/diab.38.4.441 · 1989 · External reference
Breeding of a non-obese, diabetic strain of mice
1980 · External reference
CellProfiler 4: improvements in speed, utility and usability
10.1186/s12859-021-04344-9 · 2021 · External reference
β-Cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1
10.2337/db08-0878 · 2008 · External reference
Sensitive red protein calcium indicators for imaging neural activity
10.7554/elife.12727 · 2016 · External reference
Fourth-generation epac-based FRET sensors for cAMP feature exceptional brightness, photostability and dynamic range: characterization of dedicated sensors for FLIM, for ratiometry and with high affinity
10.1371/journal.pone.0122513 · 2015 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Automated quantification of pancreatic β-cell mass
10.1152/ajpendo.00591.2013 · 2014 · External reference
Histological study of pancreatic beta-cell loss in relation to the insulitis process in the non-obese diabetic mouse
10.1007/bf00315913 · 1994 · External reference
Healthy donor polyclonal IgMs diminish B-lymphocyte autoreactivity, enhance regulatory T-cell generation, and reverse type 1 diabetes in NOD mice
10.2337/db18-0456 · 2018 · External reference
B lymphocyte “original sin” in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice
10.4049/jimmunol.1201359 · 2013 · External reference
Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice
10.1002/eji.1830180325 · 1988 · External reference
Cyclophosphamide-induced type-1 diabetes in the NOD mouse is associated with a reduction of CD4+CD25+Foxp3+ regulatory T cells
10.4049/jimmunol.177.10.6603 · 2006 · External reference
Prevention of autoimmune diabetes in NOD Mice by dimethyl fumarate
10.3390/antiox10020193 · 2021 · External reference
Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy
10.2337/diabetes.49.8.1341 · 2000 · External reference
Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
10.2337/diabetes.48.5.989 · 1999 · External reference
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
10.1074/jbc.m206911200 · 2002 · External reference
The future of type 1 diabetes therapy
10.1016/s0140-6736(25)01438-2 · 2025 · External reference
Inactivation of specific β cell transcription factors in type 2 diabetes
10.1172/jci65390 · 2013 · External reference
Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions
10.1530/joe-17-0516 · 2018 · External reference
β Cells that Resist immunological attack develop during progression of autoimmune diabetes in NOD mice
10.1016/j.cmet.2017.01.005 · 2017 · External reference
Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells
10.1074/jbc.m410345200 · 2005 · External reference
Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway
10.7554/elife.02809 · 2014 · External reference
COX2 regulates senescence secretome composition and senescence surveillance through PGE2
10.1016/j.celrep.2021.108860 · 2021 · External reference
Stress-induced β cell early senescence confers protection against type 1 diabetes
10.1016/j.cmet.2023.10.014 · 2023 · External reference
Cytokine production by islets in health and diabetes: cellular origin, regulation and function
10.1016/j.tem.2009.12.010 · 2010 · External reference
Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: a randomized phase II, placebo-controlled trial
10.1002/ibd.21080 · 2010 · External reference