Research graph
References from Human Loss-of-Function ZNRF3 Mutation Impairs Adipose Thermogenesis and Drives Subcutaneous Fat Expansion. Local targets link to admitted publications; unresolved targets remain external evidence.
Causes, consequences, and treatment of metabolically unhealthy fat distribution
10.1016/s2213-8587(20)30110-8 · 2020 · External reference
Metabolically healthy obesity: from epidemiology and mechanisms to clinical implications
10.1038/s41574-024-01008-5 · 2024 · External reference
Metabolically healthy obesity
10.1210/endrev/bnaa004 · 2020 · External reference
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
10.1038/ng.685 · 2010 · External reference
New genetic loci link adipose and insulin biology to body fat distribution
10.1038/nature14132 · 2015 · External reference
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
10.1038/ng.3714 · 2017 · External reference
FAM13A affects body fat distribution and adipocyte function
10.1038/s41467-020-15291-z · 2020 · External reference
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
10.1038/s41467-020-16592-z · 2020 · External reference
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
10.1038/nature11019 · 2012 · External reference
Integrated genomic characterization of adrenocortical carcinoma
10.1038/ng.2953 · 2014 · External reference
A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis
10.1101/gad.317412.118 · 2019 · External reference
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation
10.1016/j.stem.2021.05.013 · 2021 · External reference
RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
10.1038/s41467-021-27923-z · 2022 · External reference
ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling
10.1073/pnas.1801223115 · 2018 · External reference
Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
10.1038/ncb2867 · 2013 · External reference
CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes
10.1126/sciadv.aax9605 · 2020 · External reference
Human RSPO1 mutation represses beige adipocyte thermogenesis and contributes to diet-induced adiposity
10.1002/advs.202207152 · 2023 · External reference
Wnt signaling: from mesenchymal cell fate to lipogenesis and other mature adipocyte functions
10.2337/dbi20-0015 · 2021 · External reference
The cellular and functional complexity of thermogenic fat
10.1038/s41580-021-00350-0 · 2021 · External reference
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease
10.1038/nrendo.2017.132 · 2018 · External reference
The rs1421085 variant within FTO promotes brown fat thermogenesis
10.1038/s42255-023-00847-2 · 2023 · External reference
Intrinsic differences in adipocyte precursor cells from different white fat depots
10.2337/db11-1753 · 2012 · External reference
Association of insulin resistance and β-cell dysfunction with incident diabetes among adults in China: a nationwide, population-based, prospective cohort study
10.1016/s2213-8587(19)30425-5 · 2020 · External reference
A famsin-glucagon axis mediates glucose homeostasis
10.1016/j.cmet.2024.11.008 · 2025 · External reference
Local hyperthermia therapy induces browning of white fat and treats obesity
10.1016/j.cell.2022.02.004 · 2022 · External reference
A gain-of-function variant in RICTOR predisposes to human obesity
10.1016/j.jgg.2025.02.002 · 2025 · External reference
The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size
10.1038/ncb3337 · 2016 · External reference
Post-translational Wnt receptor regulation: is the fog slowly clearing?: the molecular mechanism of RNF43/ZNRF3 ubiquitin ligases is not yet fully elucidated and still controversial
10.1002/bies.202000297 · 2021 · External reference
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling
10.1038/s41467-024-55431-3 · 2025 · External reference
ConSurf-DB: an accessible repository for the evolutionary conservation patterns of the majority of PDB proteins
10.1002/pro.3779 · 2020 · External reference
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
10.1038/nature08111 · 2009 · External reference
OLFR734 mediates glucose metabolism as a receptor of asprosin
10.1016/j.cmet.2019.05.022 · 2019 · External reference
Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes
10.1016/j.cmet.2015.06.010 · 2015 · External reference
Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway
10.2337/db14-0496 · 2015 · External reference
PPARγ signaling and metabolism: the good, the bad and the future
10.1038/nm.3159 · 2013 · External reference
Effect of metformin and rosiglitazone combination therapy in patients with type 2 diabetes mellitus: a randomized controlled trial
10.1001/jama.283.13.1695 · 2000 · External reference
Effects of pioglitazone versus diet and exercise on metabolic health and fat distribution in upper body obesity
10.2337/diacare.26.11.3148 · 2003 · External reference
The effect of thiazolidinediones on body fat redistribution in adults: a systematic review and meta-analysis of randomized controlled trials
10.1111/obr.13675 · 2024 · External reference
Control of brown and beige fat development
10.1038/nrm.2016.96 · 2016 · External reference
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity
10.1038/nm.3615 · 2014 · External reference
Single-exon deletions of ZNRF3 exon 2 cause congenital adrenal hypoplasia
10.1210/clinem/dgad627 · 2024 · External reference
Znrf3 exon 2 deletion mice do not recapitulate congenital adrenal hypoplasia
10.1530/jme-24-0015 · 2024 · External reference
Association of a gain-of-function variant in LGR4 with central obesity
10.1002/oby.21704 · 2017 · External reference
