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References from Metabolic Blockade of Glycolysis Diminishes Autoreactive CD4 T-Cell Effector Responses in Type 1 Diabetes. Local targets link to admitted publications; unresolved targets remain external evidence.
Prevalence of type 1 diabetes among US children and adults by age, sex, race, and ethnicity
10.1001/jama.2024.2103 · 2024 · External reference
Type 1 diabetes mellitus
10.1038/nrdp.2017.16 · 2017 · External reference
2. Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes–2022
10.2337/dc22-s002 · 2022 · External reference
Pathogenesis of type 1 diabetes: established facts and new insights
10.3390/genes13040706 · 2022 · External reference
The discovery of insulin: an important milestone in the history of medicine
10.3389/fendo.2018.00613 · 2018 · External reference
Targeting mitochondrial-derived reactive oxygen species in T cell-mediated autoimmune diseases
10.3389/fimmu.2021.703972 · 2021 · External reference
CD28 signaling controls metabolic fitness of pathogenic T cells in medium and large vessel vasculitis
10.1016/j.jacc.2019.01.049 · 2019 · External reference
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
10.4049/jimmunol.180.7.4476 · 2008 · External reference
NADPH oxidase-derived superoxide provides a third signal for CD4 T cell effector responses
10.4049/jimmunol.1502581 · 2016 · External reference
Posttranscriptional control of T cell effector function by aerobic glycolysis
10.1016/j.cell.2013.05.016 · 2013 · External reference
Nutrients: signal 4 in T cell immunity
10.1084/jem.20221839 · 2024 · External reference
Energy disruptors: rising stars in anticancer therapy?
10.1038/oncsis.2015.46 · 2016 · External reference
Characterization of diabetogenic CD8+ T cells: immune therapy with metabolic blockade
10.1074/jbc.m115.713362 · 2016 · External reference
MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance
10.1172/jci.insight.157929 · 2023 · External reference
Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice
10.2337/diab.41.12.1672 · 1992 · External reference
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity
10.4049/jimmunol.1001472 · 2010 · External reference
Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T-cell effector responses in type 1 diabetes
10.2337/db15-0546 · 2015 · External reference
Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness
10.4049/jimmunol.178.2.908 · 2007 · External reference
The type 1 diabetes-associated single nucleotide polymorphism rs1990760 in IFIH1 is associated with increased basal type I IFNs and IFN-stimulated gene expression
10.4049/jimmunol.2400344 · 2024 · External reference
Effector function of diabetogenic CD4 Th1 T cell clones: a central role for TNF-alpha
10.4049/jimmunol.175.11.7738 · 2005 · External reference
Localized cytotoxic T cell-associated antigen 4 and antioxidant islet encapsulation alters macrophage signaling and induces regulatory and anergic T cells to enhance allograft survival
10.1016/j.ajt.2023.01.007 · 2023 · External reference
Dampening antigen-specific T cell responses with antigens encapsulated in polyphenolic microcapsules
10.4049/immunohorizons.2000049 · 2020 · External reference
Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages
10.4049/jimmunol.168.2.825 · 2002 · External reference
CTLA-4 control over Foxp3+ regulatory T cell function
10.1126/science.1160062 · 2008 · External reference
T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33
10.1084/jem.20182002 · 2019 · External reference
T cell anergy, exhaustion, senescence, and st.emness in the tumor microenvironment
10.1016/j.coi.2012.12.003 · 2013 · External reference
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
10.1038/ni1572 · 2008 · External reference
Regulatory T cells and immune tolerance
10.1016/j.cell.2008.05.009 · 2008 · External reference
Relationship between CD4 regulatory T cells and anergy in vivo
10.4049/jimmunol.1602031 · 2017 · External reference
Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice
10.4049/jimmunol.1301927 · 2013 · External reference
Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells
10.4049/jimmunol.1101311 · 2012 · External reference
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
10.1084/jem.20110278 · 2011 · External reference
Anergic T cells are metabolically anergic
10.4049/jimmunol.0803510 · 2009 · External reference
2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation
10.4049/jimmunol.1004085 · 2012 · External reference
Glycolysis inhibition induces functional and metabolic exhaustion of CD4+ T cells in type 1 diabetes
10.3389/fimmu.2021.669456 · 2021 · External reference
Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice
10.1016/j.biomaterials.2021.121079 · 2021 · External reference
The glycolysis inhibitor 2-deoxyglucose ameliorates adjuvant-induced arthritis by regulating macrophage polarization in an AMPK-dependent manner
10.1016/j.molimm.2021.10.007 · 2021 · External reference
3-bromopyruvate ameliorate autoimmune arthritis by modulating Th17/Treg cell differentiation and suppressing dendritic cell activation
10.1038/srep42412 · 2017 · External reference
Fluvoxamine inhibits Th1 and Th17 polarization and function by repressing glycolysis to attenuate autoimmune progression in type 1 diabetes
10.1186/s10020-024-00791-1 · 2024 · External reference
Effects of folic acid supplementation on oxidative stress markers: a systematic review and meta-analysis of randomized controlled trials
10.3390/antiox10060871 · 2021 · External reference
Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro
10.1016/j.redox.2018.08.005 · 2018 · External reference
The emerging role of one-carbon metabolism in T cells
10.1016/j.copbio.2020.12.001 · 2021 · External reference
Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
10.1186/ar2964 · 2010 · External reference
