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References from Irisin Gene Delivery Elicits Sustained Amelioration of Diabetes in Akita Mice via Insulin-Independent Regulation of Hepatic Glucose Metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Hepatic glucose and lipid metabolism
10.1007/s00125-016-3940-5 · 2016 · External reference
Energy metabolism in the liver
10.1002/j.2040-4603.2014.tb00548.x · 2014 · External reference
The Importance of the liver in insulin replacement therapy in insulin-deficient diabetes
10.2337/db14-0056 · 2014 · External reference
Diagnosis and classification of diabetes mellitus
10.2337/dc11-s062 · 2011 · External reference
Mechanisms of insulin action and insulin resistance
10.1152/physrev.00063.2017 · 2018 · External reference
Type 1 and 2 diabetes mellitus: a review on current treatment approach and gene therapy as potential intervention
10.1016/j.dsx.2018.10.008 · 2019 · External reference
Type 1 diabetes
10.1016/s0140-6736(18)31320-5 · 2018 · External reference
Glucose effectiveness: lessons from studies on insulin-independent glucose clearance in mice
10.1111/jdi.13446 · 2021 · External reference
Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease
10.1007/s00424-020-02417-x · 2020 · External reference
Glucose transporters: physiological and pathological roles
10.1007/s12551-015-0186-2 · 2016 · External reference
AMPK and exercise: glucose uptake and insulin sensitivity
10.4093/dmj.2013.37.1.1 · 2013 · External reference
Update on the effects of physical activity on insulin sensitivity in humans
10.1136/bmjsem-2016-000143 · 2016 · External reference
Exercise effect on insulin-dependent and insulin-independent glucose utilization in healthy individuals and individuals with type 1 diabetes: a modeling study
10.1152/ajpendo.00084.2021 · 2021 · External reference
Exercise in adults with type 1 diabetes mellitus
10.1038/s41574-022-00756-6 · 2023 · External reference
Exerkines in health, resilience and disease
10.1038/s41574-022-00641-2 · 2022 · External reference
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
10.1038/nature10777 · 2012 · External reference
Irisin, a fascinating field in our times
10.1016/j.tem.2022.06.003 · 2022 · External reference
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α
10.1016/j.molcel.2023.05.008 · 2023 · External reference
Irisin mediates effects on bone and fat via αV integrin receptors
10.1016/j.cell.2018.10.025 · 2018 · External reference
Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling
10.2337/db13-1106 · 2014 · External reference
Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes
10.1042/cs20150009 · 2015 · External reference
Lower levels of irisin in patients with type 2 diabetes mellitus: a meta-analysis
10.1016/j.diabres.2021.108788 · 2021 · External reference
Irisin delays the onset of type 1 diabetes in NOD mice by enhancing intestinal barrier
10.1016/j.ijbiomac.2024.130857 · 2024 · External reference
Exercise-Induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation
10.1210/jc.2014-1437 · 2014 · External reference
The use of animal models in diabetes research
10.1111/j.1476-5381.2012.01911.x · 2012 · External reference
Challenges and issues with streptozotocin-induced diabetes – a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics
10.1016/j.cbi.2015.11.032 · 2016 · External reference
Irisin gene delivery ameliorates burn-induced sensory and motor neuropathy
10.3390/ijms21207798 · 2020 · External reference
Hyperglucagonemia in an animal model of insulin-deficient diabetes: what therapy can improve it?
10.1186/s40842-016-0029-5 · 2016 · External reference
Regulation of hepatic glucose metabolism in health and disease
10.1038/nrendo.2017.80 · 2017 · External reference
Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice
10.2337/diabetes.49.10.1643 · 2000 · External reference
Hepatic glucose sensing and integrative pathways in the liver
10.1007/s00018-013-1505-z · 2014 · External reference
Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and β-cells
10.2337/diabetes.53.2007.s60 · 2004 · External reference
Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma
10.2337/diabetes.53.2007.s66 · 2004 · External reference
Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice
10.1016/j.jbc.2021.100498 · 2021 · External reference
Associations of circulating irisin with FNDC5 expression in fat and muscle in type 1 and type 2 diabetic mice
10.3390/biom11020322 · 2021 · External reference
High irisin levels are associated with better glycemic control and bone health in children with type 1 diabetes
10.1016/j.diabres.2018.03.046 · 2018 · External reference
Circulating irisin in relation to insulin resistance and the metabolic syndrome
10.1210/jc.2013-2373 · 2013 · External reference
Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels
10.1186/s12933-017-0627-2 · 2017 · External reference
Hepatic FNDC5 is a potential local protective factor against non-alcoholic fatty liver
10.1016/j.bbadis.2020.165705 · 2020 · External reference
AAV-mediated skeletal muscle specific irisin expression does not contribute to weight loss in mice
10.1016/j.bbrc.2023.10.004 · 2023 · External reference
Viral vector systems for gene therapy: a comprehensive literature review of progress and biosafety challenges
10.1177/1535676019899502 · 2020 · External reference
Adenovirus-mediated gene delivery: potential applications for gene and cell-based therapies in the new era of personalized medicine
10.1016/j.gendis.2017.04.001 · 2017 · External reference
Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle
10.1128/jvi.75.9.4276-4282.2001 · 2001 · External reference
The ADAM metalloproteinases
10.1016/j.mam.2008.08.001 · 2008 · External reference
Physiology and role of irisin in glucose homeostasis
10.1038/nrendo.2016.221 · 2017 · External reference
Unraveling the regulation of hepatic gluconeogenesis
10.3389/fendo.2018.00802 · 2018 · External reference
Progress and challenges in the biology of FNDC5 and irisin
10.1210/endrev/bnab003 · 2021 · External reference
Clinical application of adenovirus (AdV): a comprehensive review
10.3390/v16071094 · 2024 · External reference
