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References from Adipose Tissue Palmitoylation Cycling Mediates Insulin Resistance and Preservation of β-Cell Function in Mice. Local targets link to admitted publications; unresolved targets remain external evidence.
National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050
10.1016/s0140-6736(24)01548-4 · 2024 · External reference
Definition and diagnostic criteria of clinical obesity
10.1016/s2213-8587(24)00316-4 · 2025 · External reference
Global prevalence of insulin resistance in the adult population: a systematic review and meta-analysis
10.3389/fendo.2025.1646258 · 2025 · External reference
Lifetime risk to progress from pre-diabetes to type 2 diabetes among women and men: comparison between American Diabetes Association and World Health Organization diagnostic criteria
10.1136/bmjdrc-2020-001529 · 2020 · External reference
The endocrine function of adipose tissues in health and cardiometabolic disease
10.1038/s41574-019-0230-6 · 2019 · External reference
Adipose-tissue plasticity in health and disease
10.1016/j.cell.2021.12.016 · 2022 · External reference
Lipid metabolism in sickness and in health: emerging regulators of lipotoxicity
10.1016/j.molcel.2021.08.027 · 2021 · External reference
Global identification of S-palmitoylated proteins and detection of palmitoylating (DHHC) enzymes in heart
10.1016/j.yjmcc.2021.02.007 · 2021 · External reference
Depalmitoylation and cell physiology: APT1 as a mediator of metabolic signals
10.1152/ajpcell.00542.2023 · 2024 · External reference
The physiology of protein S-acylation
10.1152/physrev.00032.2014 · 2015 · External reference
Protein S-palmitoylation: advances and challenges in studying a therapeutically important lipid modification
10.1111/febs.15781 · 2022 · External reference
Endothelial palmitoylation cycling coordinates vessel remodeling in peripheral artery disease
10.1161/circresaha.120.316752 · 2020 · External reference
Extracellular vesicle R-Ras is a potential biomarker for human peripheral artery disease
10.1016/j.isci.2025.113859 · 2025 · External reference
Palmitoylation couples insulin hypersecretion with β cell failure in diabetes
10.1016/j.cmet.2022.12.012 · 2023 · External reference
Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
10.1016/j.celrep.2023.113389 · 2023 · External reference
Proteomic analysis of protein palmitoylation in adipocytes
10.4161/adip.22117 · 2013 · External reference
CalR: a web-based analysis tool for indirect calorimetry experiments
10.1016/j.cmet.2018.06.019 · 2018 · External reference
Protocol for assessing ex vivo lipolysis of murine adipose tissue
10.1016/j.xpro.2022.101518 · 2022 · External reference
A practical guide to rodent islet isolation and assessment
10.1007/s12575-009-9021-0 · 2009 · External reference
Unconventional secretion of FABP4 by endosomes and secretory lysosomes
10.1083/jcb.201705047 · 2018 · External reference
Rapid isolation of extracellular vesicles from blood plasma with size-exclusion chromatography followed by mass spectrometry-based proteomic profiling
10.1007/978-1-4939-7253-1_24 · 2017 · External reference
Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells
10.1172/jci.insight.141962 · 2021 · External reference
Site-specific analysis of protein S-acylation by resin-assisted capture
10.1194/jlr.d011106 · 2011 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
10.1038/s41467-023-36148-1 · 2023 · External reference
Adiposity-independent effects of aging on insulin sensitivity and clearance in mice and humans
10.1002/oby.22418 · 2019 · External reference
Fatty acid metabolism: target for metabolic syndrome
10.1194/jlr.r800079-jlr200 · 2009 · External reference
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance
10.2337/db12-1311 · 2013 · External reference
Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity
10.1016/j.molmet.2014.02.005 · 2014 · External reference
Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk
10.1016/j.cmet.2016.04.011 · 2016 · External reference
Genetic risk converges on regulatory networks mediating early type 2 diabetes
10.1038/s41586-023-06693-2 · 2023 · External reference
β-Cell mass and turnover in humans: effects of obesity and aging
10.2337/dc12-0421 · 2013 · External reference
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
10.2337/diabetes.52.1.102 · 2003 · External reference
Functional recovery of islet β cells in human type 2 diabetes: transcriptome signatures unveil therapeutic approaches
10.1126/sciadv.ads2905 · 2025 · External reference
Resistin and obesity-associated insulin resistance
10.1016/s1043-2760(01)00522-7 · 2002 · External reference
Metabolic functions of FABPs–mechanisms and therapeutic implications
10.1038/nrendo.2015.122 · 2015 · External reference
Pyroptosis: a possible link between obesity-related inflammation and inflammatory diseases
10.1002/jcp.30627 · 2022 · External reference
Recent insights into mechanisms of β-cell lipo- and glucolipotoxicity in type 2 diabetes
10.1016/j.jmb.2019.09.016 · 2020 · External reference
Metabolic signaling in fuel-induced insulin secretion
10.1016/j.cmet.2013.05.018 · 2013 · External reference
Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes
10.1677/joe.0.1740309 · 2002 · External reference
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
10.1172/jci7917 · 2000 · External reference
Insulin resistance in type 2 diabetes mellitus
10.1038/s41574-025-01114-y · 2025 · External reference
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
10.2337/db09-9028 · 2009 · External reference
Obesity is associated with increased basal and postprandial β-cell insulin secretion even in the absence of insulin resistance
10.2337/db20-0377 · 2020 · External reference
Metabolically healthy obesity
10.1210/endrev/bnaa004 · 2020 · External reference
High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice
10.1152/ajpendo.00460.2014 · 2015 · External reference
A high-fat diet attenuates AMPK α1 in adipocytes to induce exosome shedding and nonalcoholic fatty liver development in vivo
10.2337/db20-0146 · 2021 · External reference
A hormone complex of FABP4 and nucleoside kinases regulates islet function
10.1038/s41586-021-04137-3 · 2021 · External reference
The interplay of adipokines and pancreatic beta cells in metabolic regulation and diabetes
10.3390/biomedicines11092589 · 2023 · External reference
306-OR: Diet-induced hyperlipidation of adiponectin contributes to adiponectin dysfunction
10.2337/db24-306-or · 2024 · External reference
Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: implications for metabolic regulation and adipose tissue function
10.1016/j.celrep.2025.115732 · 2025 · External reference
Platelet-derived lipids promote insulin secretion of pancreatic β cells
10.15252/emmm.202216858 · 2023 · External reference
Why does obesity cause diabetes?
10.1016/j.cmet.2021.12.012 · 2022 · External reference
