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References from A Selective Cullin 3 RING E3 Ligase Inhibitor Attenuates Hyperglycemia via Dual Insulin Sensitizing and Insulinotropic Action. Local targets link to admitted publications; unresolved targets remain external evidence.
Function and regulation of cullin-RING ubiquitin ligases
10.1038/nrm1547 · 2005 · External reference
The cullin protein family
10.1186/gb-2011-12-4-220 · 2011 · External reference
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
10.1038/nature07884 · 2009 · External reference
Protein neddylation: beyond cullin-RING ligases
10.1038/nrm3919 · 2015 · External reference
Cullin-RING ligases as attractive anti-cancer targets
10.2174/13816128113199990300 · 2013 · External reference
Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation
10.1042/bj20141450 · 2015 · External reference
Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes
10.1016/j.metabol.2010.09.010 · 2011 · External reference
10.2337/dci22-0034 · 2022 · Admitted local publication
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization
10.1073/pnas.2111737119 · 2022 · External reference
Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity
10.1038/s41467-021-22924-4 · 2021 · External reference
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion
10.2337/diabetes.49.3.424 · 2000 · External reference
Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance
10.1073/pnas.2320934121 · 2024 · External reference
Insulin signaling in the pancreatic beta-cell
10.1146/annurev.nutr.28.061807.155530 · 2008 · External reference
Direct autocrine action of insulin on β-cells: does it make physiological sense?
10.2337/db13-0246 · 2013 · External reference
β-Cell receptor tyrosine kinases in controlling insulin secretion and exocytotic machinery: c-Kit and insulin receptor
10.1210/en.2018-00716 · 2018 · External reference
Disruption of IRS-2 causes type 2 diabetes in mice
10.1038/36116 · 1998 · External reference
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
10.1038/12631 · 1999 · External reference
Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells
10.1074/jbc.m600356200 · 2006 · External reference
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance
10.1172/jci17645 · 2007 · External reference
Calcineurin signaling regulates human islet β-cell survival
10.1074/jbc.m110.154955 · 2010 · External reference
Regulation of insulin synthesis and secretion and pancreatic beta-cell dysfunction in diabetes
10.2174/157339913804143225 · 2013 · External reference
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement
10.1016/j.molcel.2009.09.004 · 2009 · External reference
Hypertension-causing mutations in Cullin3 protein impair RhoA protein ubiquitination and augment the association with substrate adaptors
10.1074/jbc.m115.645358 · 2015 · External reference
Rho-kinase/ROCK: a key regulator of the cytoskeleton and cell polarity
10.1002/cm.20472 · 2010 · External reference
Signaling networks that regulate cell migration
10.1101/cshperspect.a005959 · 2015 · External reference
Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion
10.1074/jbc.m111.279885 · 2012 · External reference
In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography
10.1038/s41467-024-45648-7 · 2024 · External reference
The skeleton in the closet: actin cytoskeletal remodeling in β-cell function
10.1152/ajpendo.00268.2015 · 2015 · External reference
Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion
10.1074/jbc.m113.464420 · 2013 · External reference
Disrupting actin filaments enhances glucose-stimulated insulin secretion independent of the cortical actin cytoskeleton
10.1016/j.jbc.2023.105334 · 2023 · External reference
Rho GTPases and the actin cytoskeleton
10.1126/science.279.5350.509 · 1998 · External reference
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
10.1101/gad.13.18.2375 · 1999 · External reference
The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells
10.1172/jci41959 · 2010 · External reference
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3
10.1172/jci76126 · 2014 · External reference
Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension
10.1172/jci.insight.129793 · 2019 · External reference
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development
10.1038/s41467-021-23123-x · 2021 · External reference
A novel missense variant in CUL3 shows altered binding ability to BTB-adaptor proteins leading to diverse phenotypes of CUL3-related disorders
10.1038/s10038-020-00868-9 · 2021 · External reference
Loss-of-function variants in CUL3 cause a syndromic neurodevelopmental disorder
10.1002/ana.27077 · 2025 · External reference
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
10.1038/nature10814 · 2012 · External reference
Cullin 3 and blood pressure regulation: insights from familial hyperkalemic hypertension
10.1161/hypertensionaha.123.20525 · 2023 · External reference
Always look on the bright site of Rho: structural implications for a conserved intermolecular interface
10.1038/sj.embor.7400293 · 2004 · External reference
Arp2/3 nucleates F-actin coating of fusing insulin granules in pancreatic β cells to control insulin secretion
10.1242/jcs.236794 · 2020 · External reference
The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells
10.1073/pnas.2016997117 · 2020 · External reference
Pancreatic beta-cell web: its possible role in insulin secretion
10.1126/science.175.4026.1128 · 1972 · External reference
Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion
10.1152/ajpcell.00093.2003 · 2003 · External reference
Amplification of insulin secretion by acetylcholine or phorbol ester is independent of β-cell microfilaments and distinct from metabolic amplification
10.1016/j.mce.2012.12.002 · 2013 · External reference
Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells
10.1038/emm.2013.73 · 2013 · External reference
