Research graph
References from Islet-Targeted ZnT8 Antibodies Protect Pancreatic β-Cells From Inflammatory Stress. Local targets link to admitted publications; unresolved targets remain external evidence.
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
10.1038/s41574-020-00443-4 · 2021 · External reference
Islet inflammation in type 2 diabetes and physiology
10.1172/jci88877 · 2017 · External reference
Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
10.1038/s41574-020-0355-7 · 2020 · External reference
From endoplasmic-reticulum stress to the inflammatory response
10.1038/nature07203 · 2008 · External reference
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
10.1016/j.ebiom.2018.09.040 · 2018 · External reference
PD-1 and its ligands in tolerance and immunity
10.1146/annurev.immunol.26.021607.090331 · 2008 · External reference
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
10.1038/nature22396 · 2017 · External reference
Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival
10.1126/sciadv.aba5573 · 2020 · External reference
Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes
10.1007/s00125-016-4067-4 · 2016 · External reference
Inflammatory cell infiltration into islets without PD-L1 expression is associated with the development of immune checkpoint inhibitor-related type 1 diabetes in genetically susceptible patients
10.2337/db22-0557 · 2023 · External reference
Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms
10.1007/s00125-015-3669-6 · 2015 · External reference
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes
10.1126/scitranslmed.3006534 · 2013 · External reference
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
10.1126/science.1128294 · 2006 · External reference
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus
10.1038/s41574-021-00510-4 · 2021 · External reference
Single-cell transcriptome profiling of human pancreatic islets in health and type 2 diabetes
10.1016/j.cmet.2016.08.020 · 2016 · External reference
Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
10.2337/diabetes.53.9.2330 · 2004 · External reference
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress
10.1074/jbc.ra119.010937 · 2019 · External reference
Identification of unique cell type responses in pancreatic islets to stress
10.1038/s41467-024-49724-w · 2024 · External reference
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
10.1038/s41588-019-0513-9 · 2019 · External reference
ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes
10.1038/s41467-022-31829-9 · 2022 · External reference
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity
10.1073/pnas.1721418115 · 2018 · External reference
Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration
10.1016/j.molmet.2022.101632 · 2022 · External reference
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
10.1073/pnas.0906587106 · 2009 · External reference
Unresolved reference
External reference
Coupling of insulin secretion and display of a granule-resident zinc transporter ZnT8 on the surface of pancreatic beta cells
10.1074/jbc.m116.772152 · 2017 · External reference
Cell-surface autoantibody targets zinc transporter-8 (ZnT8) for in vivo β-cell imaging and islet-specific therapies
10.2337/db22-0477 · 2023 · External reference
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
10.1073/pnas.0705894104 · 2007 · External reference
Novel autoantibodies to the β-cell surface epitopes of ZnT8 in patients progressing to type-1 diabetes
10.1016/j.jaut.2021.102677 · 2021 · External reference
A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells
10.1074/jbc.ra117.000195 · 2018 · External reference
Cell-surface ZnT8 antibody prevents and reverses autoimmune diabetes in mice
10.2337/db23-0568 · 2024 · External reference
Lipid-tuned zinc transport activity of human ZnT8 protein correlates with risk for type-2 diabetes
10.1074/jbc.m116.764605 · 2016 · External reference
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
10.1172/jci58447 · 2011 · External reference
Automated quantification of pancreatic β-cell mass
10.1152/ajpendo.00591.2013 · 2014 · External reference
Liraglutide protects β-cells in novel human islet spheroid models of type 1 diabetes
10.1016/j.clim.2022.109118 · 2022 · External reference
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
10.1038/s42255-020-0269-7 · 2020 · External reference
Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies
10.1182/blood-2010-09-305847 · 2011 · External reference
Acute versus progressive onset of diabetes in NOD mice: potential implications for therapeutic interventions in type 1 diabetes
10.2337/db15-0449 · 2015 · External reference
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model
10.2337/db11-1293 · 2012 · External reference
Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes
10.2337/db12-0701 · 2013 · External reference
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
10.1038/s41574-019-0286-3 · 2020 · External reference
Increased number of islet-associated macrophages in type 2 diabetes
10.2337/db06-1650 · 2007 · External reference
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
10.1172/jci4431 · 1999 · External reference
The mechanisms of alloxan- and streptozotocin-induced diabetes
10.1007/s00125-007-0886-7 · 2008 · External reference
Cytokines suppress human islet function irrespective of their effects on nitric oxide generation
10.1172/jci117188 · 1994 · External reference
Humanized mice in translational biomedical research
10.1038/nri2017 · 2007 · External reference
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
10.1038/ng.2915 · 2014 · External reference
IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells
10.1007/s00125-017-4536-4 · 2018 · External reference
Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
10.1007/s00125-016-4201-3 · 2017 · External reference
Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity
10.1038/ncomms12632 · 2016 · External reference
Pathways of antigen processing
10.1146/annurev-immunol-032712-095910 · 2013 · External reference
The therapeutic potential of PD-1/PD-L1 pathway on immune-related diseases: based on the innate and adaptive immune components
10.1016/j.biopha.2023.115569 · 2023 · External reference
