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References from Myeloid-Specific Heparanase Aggravates Insulitis in Type 1 Diabetes via Heparan Sulfate Fragment-Dependent Amplification of Macrophage Polarization. Local targets link to admitted publications; unresolved targets remain external evidence.
Type 1 diabetes
10.1016/s0140-6736(18)31320-5 · 2018 · External reference
Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals
10.1126/scitranslmed.abc8980 · 2021 · External reference
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)
10.1038/s41574-020-00443-4 · 2021 · External reference
New frontiers in the treatment of type 1 diabetes
10.1016/j.cmet.2019.11.017 · 2020 · External reference
Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice
10.1073/pnas.1713543114 · 2017 · External reference
Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes
10.1016/j.ebiom.2025.105946 · 2025 · External reference
Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality
10.1007/s00125-025-06445-z · 2025 · External reference
Loss of NADPH oxidase-derived superoxide skews macrophage phenotypes to delay type 1 diabetes
10.2337/db14-0929 · 2015 · External reference
Phagocytosis and efferocytosis by resident macrophages in the mouse pancreas
10.3389/fendo.2021.606175 · 2021 · External reference
Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death
10.1038/s41586-025-09560-4 · 2025 · External reference
Extracellular matrix components in the pathogenesis of type 1 diabetes
10.1007/s11892-014-0552-7 · 2014 · External reference
Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans
10.1371/journal.pone.0191360 · 2018 · External reference
Heparanase, heparan sulfate and viral infection
10.1007/978-3-030-34521-1_32 · 2020 · External reference
Inhibition of heparanase protects against pancreatic beta cell death in streptozotocin-induced diabetic mice via reducing intra-islet inflammatory cell infiltration
10.1111/bph.15183 · 2020 · External reference
PPARγ activation reduces pancreatic beta cell death in type 1 diabetes by decreasing heparanase-dependent insulitis
10.1016/j.intimp.2025.115183 · 2025 · External reference
Heparan sulfate proteoglycans (HSPGs) and their degradation in health and disease
10.3390/biom15111597 · 2025 · External reference
Heparanase: historical aspects and future perspectives
10.1007/978-3-030-34521-1_3 · 2020 · External reference
Heparanase: from basic research to therapeutic applications in cancer and inflammation
10.1016/j.drup.2016.10.001 · 2016 · External reference
Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes
10.1172/jci46177 · 2012 · External reference
NIH initiative to improve understanding of the pancreas, islet, and autoimmunity in type 1 diabetes: the Human Pancreas Analysis Program (HPAP)
10.2337/db19-0058 · 2019 · External reference
Targeted elimination of senescent beta cells prevents type 1 diabetes
10.1016/j.cmet.2019.01.021 · 2019 · External reference
Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes
10.1084/jem.20192362 · 2020 · External reference
TGF-β-mediated crosstalk between TIGIT+ Tregs and CD226+CD8+ T cells in the progression and remission of type 1 diabetes
10.1038/s41467-024-53264-8 · 2024 · External reference
Interfacing Seurat with the R tidy universe
10.1093/bioinformatics/btab404 · 2021 · External reference
DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors
10.1016/j.cels.2019.03.003 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation
10.1007/s11427-022-2372-y · 2024 · External reference
The heparan sulfate mimetic muparfostat aggravates steatohepatitis in obese mice due to its binding affinity to lipoprotein lipase
10.1111/bph.16047 · 2023 · External reference
Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes
10.1038/nprot.2014.183 · 2014 · External reference
Importance of heparan sulfate proteoglycans in pancreatic islets and β-cells
10.3390/ijms232012082 · 2022 · External reference
The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes
10.1186/s12964-025-02372-z · 2025 · External reference
Redox-sensitive innate immune pathways during macrophage activation in type 1 diabetes
10.1089/ars.2017.7243 · 2018 · External reference
Coreceptor functions of cell surface heparan sulfate proteoglycans
10.1152/ajpcell.00050.2022 · 2022 · External reference
Glycosylation of FGF/FGFR: an underrated sweet code regulating cellular signaling programs
10.1016/j.cytogfr.2024.04.001 · 2024 · External reference
Heparan sulfate promotes ACE2 super-cluster assembly to enhance SARS-CoV-2-associated syncytium formation
10.1038/s41467-023-41453-w · External reference
Heparan sulfate organizes neuronal synapses through neurexin partnerships
10.1016/j.cell.2018.07.002 · 2018 · External reference
Heparanase and chemotherapy synergize to drive macrophage activation and enhance tumor growth
10.1158/0008-5472.can-19-1676 · 2020 · External reference
Helicobacter pylori-induced heparanase promotes H. pylori colonization and gastritis
10.3389/fimmu.2021.675747 · 2021 · External reference
Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4
10.1371/journal.pone.0109596 · 2014 · External reference
Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury
10.1096/fj.201700597r · 2018 · External reference
Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS-) vs. alternatively activated macrophages
10.3389/fimmu.2019.01084 · 2019 · External reference
Polarizing macrophages in vitro
10.1007/978-1-4939-7837-3_12 · 2018 · External reference
Complexity of danger: the diverse nature of damage-associated molecular patterns
10.1074/jbc.r114.619304 · 2014 · External reference
Interferon and heparan sulphate
10.1042/bst0340461 · 2006 · External reference
Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy
10.1111/febs.13932 · 2017 · External reference
Endogenous ligands of Toll-like receptors
10.1189/jlb.0304127 · 2004 · External reference
Heparanase: a challenging cancer drug target
10.3389/fonc.2019.01316 · 2019 · External reference
Discovery and development of small-molecule heparanase inhibitors
10.1016/j.bmc.2023.117335 · 2023 · External reference
PI-88 and related heparan sulfate mimetics
10.1007/978-3-030-34521-1_19 · 2020 · External reference
