Research graph
References from Vascular Regenerative Cell Flux in Diabetes: Mechanistic and Clinical Implications. Local targets link to admitted publications; unresolved targets remain external evidence.
Concise review: cell therapy for critical limb ischemia: an integrated review of preclinical and clinical studies
10.1002/stem.2751 · 2018 · External reference
Circulating pro-vascular progenitor cell depletion during type 2 diabetes: translational insights into the prevention of ischemic complications in diabetes
10.1016/j.jacbts.2018.10.005 · 2019 · External reference
Semaglutide promotes bone marrow-derived progenitor cell flux towards an anti-inflammatory and pro-regenerative profile in high-risk patients: the SEMA-VR CardioLink-15 trial
10.1093/eurheartj/ehaf690 · 2026 · External reference
Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects
10.3389/fendo.2024.1396794 · 2024 · External reference
Icosapent ethyl modulates circulating vascular regenerative cell content: the IPE-PREVENTION CardioLink-14 trial
10.1016/j.medj.2024.03.009 · 2024 · External reference
SGLT2 inhibition with empagliflozin increases circulating provascular progenitor cells in people with type 2 diabetes mellitus
10.1016/j.cmet.2019.08.015 · 2019 · External reference
Vascular regenerative cell deficiencies in South Asian adults
10.1016/j.jacc.2023.12.012 · 2024 · External reference
Quantifying and understanding the higher risk of atherosclerotic cardiovascular disease among South Asian individuals: results from the UK Biobank prospective cohort study
10.1161/circulationaha.120.052430 · 2021 · External reference
Cardiometabolic risk management: insights from a European Society of Cardiology Cardiovascular Round Table
10.1093/eurheartj/ehad445 · 2023 · External reference
Aldehyde dehydrogenases: not just markers, but functional regulators of stem cells
10.1155/2019/3904645 · 2019 · External reference
High aldehyde dehydrogenase activity identifies a subset of human mesenchymal stromal cells with vascular regenerative potential
10.1002/stem.2612 · 2017 · External reference
Expansion of umbilical cord blood aldehyde dehydrogenase expressing cells generates myeloid progenitor cells that stimulate limb revascularization
10.1002/sctm.16-0472 · 2017 · External reference
Vascular risk reduction in obesity through reduced granulocyte burden and improved angiogenic monocyte content following bariatric surgery
10.1016/j.xcrm.2020.100018 · 2020 · External reference
Worldwide trends in diabetes prevalence and treatment from 1990 to 2022: a pooled analysis of 1108 population-representative studies with 141 million participants
10.1016/s0140-6736(24)02317-1 · 2024 · External reference
Unresolved reference
External reference
Prevalence and prevention of cardiovascular disease and diabetes mellitus
10.1016/j.phrs.2016.09.040 · 2016 · External reference
Trends in the association between diabetes and cardiovascular events, 1994-2019
10.1001/jama.2022.14914 · 2022 · External reference
Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy
10.1016/j.exer.2010.05.012 · 2010 · External reference
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene
10.1161/01.res.0000231289.63468.08 · 2006 · External reference
Diabetes irreversibly depletes bone marrow–derived mesenchymal progenitor cell subpopulations
10.2337/db13-1366 · 2014 · External reference
Diabetes impairs adipose tissue-derived stem cell function and efficiency in promoting wound healing
10.1111/wrr.12051 · 2013 · External reference
In vitro hyperglycemia or a diabetic intrauterine environment reduces neonatal endothelial colony-forming cell numbers and function
10.2337/db07-1507 · 2008 · External reference
Endothelial cell phenotype is linked to endothelial dysfunction in individuals with a family history of type 2 diabetes
10.1515/hmbci-2024-0070 · 2025 · External reference
Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances
10.1038/s41392-025-02142-w · 2025 · External reference
Notch signaling in diabetic kidney disease: recent progress
10.3389/fendo.2025.1537769 · 2025 · External reference
Advanced glycation end products and diabetes mellitus: mechanisms and perspectives
10.3390/biom12040542 · 2022 · External reference
Metabolomics and proteomics in type 2 diabetes
10.1161/circresaha.120.315898 · 2020 · External reference
In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study
10.1007/s00125-019-4960-8 · 2019 · External reference
Umbilical cord blood-derived aldehyde dehydrogenase-expressing progenitor cells promote recovery from acute ischemic injury
10.1002/stem.1206 · 2012 · External reference
A new in vivo model using a dorsal skinfold chamber to investigate microcirculation and angiogenesis in diabetic wounds
2016 · External reference
Type 2 diabetes restricts multipotency of mesenchymal stem cells and impairs their capacity to augment postischemic neovascularization in db/db mice
10.1161/jaha.112.002238 · 2012 · External reference
Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus
10.1371/journal.pone.0060357 · 2013 · External reference
Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock
10.1002/ejhf.2588 · 2022 · External reference
Hallmarks of transcriptional heterogeneity in human hematopoietic stem cells across 382 donors
10.1182/blood-2024-212079 · 2024 · External reference
Endothelial progenitor cells as biomarkers of diabetes-related cardiovascular complications
10.1186/s13287-023-03537-8 · 2023 · External reference
The long telling story of “endothelial progenitor cells”: where are we at now?
10.3390/cells12010112 · 2022 · External reference
Colony forming unites-endothelial progenitor cells (CFU-EPCs): a surrogate marker for diabetic retinopathy and high cardiovascular mortality rate
2016 · External reference
Functional impairment of endothelial colony forming cells (ECFC) in patients with severe atherosclerotic cardiovascular disease (ASCVD)
10.3390/ijms23168969 · 2022 · External reference
Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics
10.1038/s41598-019-38921-z · 2019 · External reference
Boosting scRNA-seq data clustering by cluster-aware feature weighting
10.1186/s12859-021-04033-7 · 2021 · External reference
Exploring biomarkers and transcriptional factors in type 2 diabetes by comprehensive bioinformatics analysis on RNA-Seq and scRNA-Seq data
10.21037/atm-22-4303 · 2022 · External reference
Abstract 365: altered gene expression and impaired repair functions of circulating endothelial colony-forming cells from diabetic patients
10.1161/atvb.43.suppl_1.365 · 2023 · External reference
Single-cell analysis of human PBMCs in healthy and type 2 diabetes populations: dysregulated immune networks in type 2 diabetes unveiled through single-cell profiling
10.3389/fendo.2024.1397661 · 2024 · External reference
Blood monocyte phenotype is a marker of cardiovascular risk in type 2 diabetes
10.1161/circresaha.123.322757 · 2024 · External reference
Endoplasmic reticulum stress and dysregulated autophagy in human pancreatic beta cells
10.4093/dmj.2022.0070 · 2022 · External reference
Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes
10.1016/j.molmet.2021.101330 · 2021 · External reference
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
10.1016/s2213-8587(18)30051-2 · 2018 · External reference
Plasma amino acid levels and insulin secretion in obesity
10.1056/nejm196910092811503 · 1969 · External reference
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
10.1016/j.cmet.2009.02.002 · 2009 · External reference
Metabolite profiles and the risk of developing diabetes
10.1038/nm.2307 · 2011 · External reference
Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a Mendelian randomisation analysis
10.1371/journal.pmed.1002179 · 2016 · External reference
Genetic evidence of a causal effect of insulin resistance on branched-chain amino acid levels
10.1007/s00125-017-4222-6 · 2017 · External reference
Sex hormone-binding globulin and risk of type 2 diabetes in women and men
10.1056/nejmoa0804381 · 2009 · External reference
Plasma concentrations of afamin are associated with prevalent and incident type 2 diabetes: a pooled analysis in more than 20,000 individuals
10.2337/dc17-0201 · 2017 · External reference
Protein biomarkers for insulin resistance and type 2 diabetes risk in two large community cohorts
10.2337/db15-0881 · 2016 · External reference
Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization
10.1016/j.atherosclerosis.2013.10.036 · 2014 · External reference
Development and validation of a protein-based risk score for cardiovascular outcomes among patients with stable coronary heart disease
10.1001/jama.2016.5951 · 2016 · External reference
Quiescent endothelial cells upregulate fatty acid β-oxidation for vasculoprotection via redox homeostasis
10.1016/j.cmet.2018.07.016 · 2018 · External reference
Endothelial progenitor cells for diabetic cardiac and kidney disease
10.1093/stcltm/szae025 · 2024 · External reference
Angiogenesis in adipose tissue: the interplay between adipose and endothelial cells
10.3389/fphys.2020.624903 · 2020 · External reference
Pericyte recruitment in a diabetic mouse model of corneal neovascularization
10.1096/fasebj.30.1_supplement.721.13 · 2016 · External reference
Image-guided pro-angiogenic therapy in diabetic stroke mouse models using a multi-modal nanoprobe
10.7150/thno.9525 · 2014 · External reference
Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells
10.1002/sctm.20-0506 · 2021 · External reference
Diabetic mesenchymal stem cells are ineffective for improving limb ischemia due to their impaired angiogenic capability
10.3727/096368914x682792 · 2015 · External reference
Decellularized adipose tissue scaffolds guide hematopoietic differentiation and stimulate vascular regeneration in a hindlimb ischemia model
10.1016/j.biomaterials.2021.120867 · 2021 · External reference
Candesartan protects against unilateral peripheral limb ischemia in type-2 diabetic rats: possible contribution of PI3K-Akt-eNOS-VEGF angiogenic signaling pathway
10.1016/j.intimp.2023.109817 · 2023 · External reference
Low level LASER therapy induces therapeutic angiogenesis in diabetic mice with hindlimb ischemia
10.1101/496208 · External reference
Trimetazidine ameliorates hindlimb ischaemic damage in type 2 diabetic mice
10.1080/07853890.2021.1925147 · 2021 · External reference
Praliciguat promotes ischemic leg reperfusion in leptin receptor-deficient mice
10.1161/circresaha.122.322033 · 2023 · External reference
MicroRNA-21/PDCD4 proapoptotic signaling from circulating CD34+ cells to vascular endothelial cells: a potential contributor to adverse cardiovascular outcomes in patients with critical limb ischemia
10.2337/dc19-2227 · 2020 · External reference
Stem cell-based clinical trials for diabetes mellitus
10.3389/fendo.2021.631463 · 2021 · External reference
