Research graph
References from A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder Webservice,Wiki and Databases. Local targets link to admitted publications; unresolved targets remain external evidence.
Structural Basis of Gabija Anti-Phage Defence and Viral Immune Evasion
10.1038/s41586-023-06855-2 · 2024 · External reference
Prokaryotic Viperins Produce Diverse Antiviral Molecules
10.1038/s41586-020-2762-2 · 2021 · External reference
Argonaute Proteins Confer Immunity in All Domains of Life
10.1016/j.mib.2023.102313 · 2023 · External reference
Improved Prediction of Protein-Protein Interactions Using AlphaFold2
10.1038/s41467-022-28865-w · 2022 · External reference
RCSB Protein Data Bank (RCSB.Org): Delivery of Experimentally-Determined PDB Structures alongside One Million Computed Structure Models of Proteins from Artificial Intelligence/Machine Learning
10.1093/nar/gkac1077 · 2023 · External reference
BLAST+: Architecture and Applications
10.1186/1471-2105-10-421 · 2009 · External reference
Phage Abortive Infection in Lactococci: Variations on a Theme
10.1016/j.mib.2005.06.006 · 2005 · External reference
Accumulation of Defense Systems in Phage Resistant Strains of Pseudomonas Aeruginosa
10.1101/2022.08.12.503731 · 2023 · External reference
Prophage-Mediated Defence against Viral Attack and Viral Counter-Defence
10.1038/nmicrobiol.2016.251 · 2017 · External reference
The SMC-family Wadjet Complex Protects Bacteria from Plasmid Transformation by Recognition and Cleavage of Closed-Circular DNA
10.1016/j.molcel.2022.09.008 · 2022 · External reference
Effector-Mediated Membrane Disruption Controls Cell Death in CBASS Antiphage Defense
10.1016/j.molcel.2021.10.020 · 2021 · External reference
Cryo-EM Structure of the RADAR Supramolecular Anti-Phage Defense Complex
10.1016/j.cell.2023.01.012 · 2023 · External reference
Abortive Phage Resistance Mechanism AbiZ Speeds the Lysis Clock To Cause Premature Lysis of Phage-Infected Lactococcus Lactis
10.1128/jb.00904-06 · 2007 · External reference
Accelerated Profile HMM Searches
10.1371/journal.pcbi.1002195 · 2011 · External reference
Protein Complex Prediction with AlphaFold-Multimer
10.1101/2021.10.04.463034 · 2022 · External reference
Predicting Phage-Bacteria Interactions at the Strain Level from Genomes
10.1101/2023.11.22.567924 · 2023 · External reference
The Highly Diverse Antiphage Defence Systems of Bacteria
10.1038/s41579-023-00934-x · 2023 · External reference
Escherichia Coli mazEF-mediated Cell Death as a Defense Mechanism That Inhibits the Spread of Phage P1
10.1007/s00438-004-1048-y · 2004 · External reference
Phage Defence by Deaminase-Mediated Depletion of Deoxynucleotides in Bacteria
10.1038/s41564-022-01162-4 · 2022 · External reference
Rapid Evolutionary Turnover of Mobile Genetic Elements Drives Bacterial Resistance to Phages
10.1126/science.abb1083 · 2021 · External reference
Bacterial Gasdermins Reveal an Ancient Mechanism of Cell Death
10.1126/science.abj8432 · 2022 · External reference
Highly Accurate Protein Structure Prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Structural and Functional Evidence of Bacterial Antiphage Protection by Thoeris Defense System via NAD+ Degradation
10.1038/s41467-020-16703-w · 2020 · External reference
\emphEscherichia Coli \emphrnlA and \emphrnlB Compose a Novel Toxin–Antitoxin System
10.1534/genetics.110.121798 · 2011 · External reference
Pyrodigal: Python Bindings and Interface to Prodigal, an Efficient Method for Gene Prediction in Prokaryotes
10.21105/joss.04296 · 2022 · External reference
The DarTG Toxin-Antitoxin System Provides Phage Defense by ADP-ribosylating Viral DNA
10.1101/2021.09.27.462013 · 2021 · External reference
PtuA and PtuB Assemble into an Inflammasome-like Oligomer for Anti-Phage Defense
10.1038/s41594-023-01172-8 · 2024 · External reference
Evolutionary-Scale Prediction of Atomic-Level Protein Structure with a Language Model
10.1126/science.ade2574 · 2023 · External reference
Mycobacterium Phage Butters-Encoded Proteins Contribute to Host Defense against Viral Attack
10.1128/msystems.00534-20 · 2020 · External reference
pA Public Galaxy Platform at Pasteur Used as an Execution Engine for Web Services/P
10.7490/f1000research.1114334.1 · 2017 · External reference
Systematic Prediction of Genes Functionally Associated with Bacterial Retrons and Classification of the Encoded Tripartite Systems
10.1093/nar/gkaa1149 · 2020 · External reference
Bacterial Retrons Function In Anti-Phage Defense
10.1016/j.cell.2020.09.065 · 2020 · External reference
Diversity and Classification of Cyclic-Oligonucleotide-Based Anti-Phage Signalling Systems
10.1038/s41564-020-0777-y · 2020 · External reference
An Expanded Arsenal of Immune Systems That Protect Bacteria from Phages
10.1016/j.chom.2022.09.017 · 2022 · External reference
Pfam: The Protein Families Database in 2021
10.1093/nar/gkaa913 · 2021 · External reference
Molecular Mechanisms of CRISPR-Cas Immunity in Bacteria
10.1146/annurev-genet-022120-112523 · 2020 · External reference
10.24072/pcjournal.250 · 2023 · Admitted local publication
Reference Sequence (RefSeq) Database at NCBI: Current Status, Taxonomic Expansion, and Functional Annotation
10.1093/nar/gkv1189 · 2016 · External reference
Phage-Host Coevolution in Natural Populations
10.1038/s41564-022-01157-1 · 2022 · External reference
A Conserved Family of Immune Effectors Cleaves Cellular ATP upon Viral Infection
10.1016/j.cell.2023.07.020 · 2023 · External reference
Phages and Their Satellites Encode Hotspots of Antiviral Systems
10.1016/j.chom.2022.02.018 · 2022 · External reference
Discovery of Functional Toxin/Antitoxin Systems in Bacteria by Shotgun Cloning
10.1016/j.molcel.2013.02.002 · 2013 · External reference
Mol* Viewer: Modern Web App for 3D Visualization and Analysis of Large Biomolecular Structures
10.1093/nar/gkab314 · 2021 · External reference
Assembly-Mediated Activation of the SIR2-HerA Supramolecular Complex for Anti-Phage Defense
10.1016/j.molcel.2023.11.007 · 2023 · External reference
Bacteria Deplete Deoxynucleotides to Defend against Bacteriophage Infection
10.1038/s41564-022-01158-0 · 2022 · External reference
Multiple Enzymatic Activities of a Sir2-HerA System Cooperate for Anti-Phage Defense
10.1016/j.molcel.2023.11.010 · 2023 · External reference
Synergy and Regulation of Antiphage Systems: Toward the Existence of a Bacterial Immune System?
10.1016/j.mib.2022.102238 · 2023 · External reference
Systematic and Quantitative View of the Antiviral Arsenal of Prokaryotes
10.1038/s41467-022-30269-9 · 2022 · External reference
Code for the DefenseFinder Wiki
10.5281/zenodo.13762622 · 2024 · External reference
The Galaxy Platform for Accessible, Reproducible and Collaborative Biomedical Analyses: 2022 Update
10.1093/nar/gkac247 · 2022 · External reference
The Biology of Restriction and Anti-Restriction
10.1016/j.mib.2005.06.003 · 2005 · External reference
UniProt: The Universal Protein Knowledgebase in 2023
10.1093/nar/gkac1052 · 2023 · External reference
Fast and Accurate Protein Structure Search with Foldseek
10.1038/s41587-023-01773-0 · 2023 · External reference
AlphaFold Protein Structure Database: Massively Expanding the Structural Coverage of Protein-Sequence Space with High-Accuracy Models
10.1093/nar/gkab1061 · 2022 · External reference
DefenseFinder update advances prokaryotic antiviral system research
10.24072/pci.genomics.100373 · 2024 · External reference
CARD-like Domains Mediate Anti-Phage Defense in Bacterial Gasdermin Systems
10.1101/2023.05.28.542683 · 2023 · External reference
A Short Prokaryotic Argonaute Activates Membrane Effector to Confer Antiviral Defense
10.1016/j.chom.2022.04.015 · 2022 · External reference
Direct Activation of a Bacterial Innate Immune System by a Viral Capsid Protein
10.1038/s41586-022-05444-z · 2022 · External reference
