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References from Modelling of ORL1 receptor-ligand interactions. Local targets link to admitted publications; unresolved targets remain external evidence.
Pharmacological characterization of pX nociceptin amide analogues Naunyn - Schmiedeberg s Archives of
10.1007/s00210-002-0548-8.http://dx.doi.org/10.1007/s00210-002-0548-8 · 2002 · External reference
Residual roles of hydrophobic amino acids in the fifth transmembrane domain of ORL receptor in its activation
2006 · External reference
QSAR homology modeling and molecular docking studies on spiropiperidines analogues as agonists of nociceptin / orphanin FQ receptor Bioorganic
10.1016/j.bmcl.2010.09.116.http://dx.doi.org/10.1016/j.bmcl.2010.09.116 · 2010 · External reference
Structure and function of an irreversible agonist - β - adrenoceptor complex
10.1038/nature09665.http://dx.doi.org/10.1038/nature09665 · 2011 · External reference
Moving from the orphanin FQ receptor to an opioid receptor using four point mutations
10.1074/jbc.271.50.32016.http://dx.doi.org/10.1074/jbc.271.50.32016 · 1996 · External reference
Conserved binding mode of human β - adrenergic receptor inverse agonists and antagonist revealed by X - ray crystallography
10.1021/ja105108q.http://dx.doi.org/10.1021/ja105108q · 2010 · External reference
Action of molecular switches in GPCRs theoretical and experimental studies
10.2174/092986712799320556.http://dx.doi.org/10.2174/092986712799320556 · 2012 · External reference
VMD : Visual molecular dynamics
10.1016/0263-7855(96)00018-5.http://dx.doi.org/10.1016/0263-7855(96)00018-5 · 1996 · External reference
Distinct mechanisms for activation of the opioid receptor - like and κ - opioid receptors by nociceptin and dynorphin A
10.1124/mol.55.2.324 · 1999 · External reference
Opioid receptor - like molecular Road Map to understanding ligand interaction and selectivity
10.2174/1568026053544489.http://dx.doi.org/10.2174/1568026053544489 · 2005 · External reference
Optimization of parameters for semiempirical methods V : Modification of NDDO approximations and application to elements
10.1007/s00894-007-0233-4.http://dx.doi.org/10.1007/s00894-007-0233-4 · 2007 · External reference
Functional inactivation of the nociceptin receptor by alanine substitution of glutamine at the C terminus of transmembrane segment VI : Evidence from a site - directed mutagenesis study of the ORL receptor transmembrane - binding domain
10.1124/mol.57.3.495 · 2000 · External reference
Del Synthesis and evaluation as NOP ligands of some spiro piperidine quinazolin ones and spiro piperidine triazolo quinazolines Chemical
10.1248/cpb.54.611.http://dx.doi.org/10.1248/cpb.54.611 · 2006 · External reference
A new bioinformatics analysis tools framework at EMBL - EBI
10.1093/nar/gkq313.http://dx.doi.org/10.1093/nar/gkq313 · 2010 · External reference
Integrated methods for the construction of three - dimensional models and computational probing of structure - function relations in G - proteincoupled receptors in
10.1016/s1043-9471(05)80049-7.http://dx.doi.org/10.1016/s1043-9471(05)80049-7 · 1995 · External reference
Comparative molecular modeling on D - structure of opioid receptor - like receptor
2000 · External reference
Small - molecule agonists and antagonists of the opioid receptor - like receptor ORL Ligand - based analysis of structural factors influencing intrinsic activity at NOP
10.1208/aapsj070234.http://dx.doi.org/10.1208/aapsj070234 · 2005 · External reference
Insights into signaling from the β - adrenergic receptor structure
10.1038/nchembio.97.http://dx.doi.org/10.1038/nchembio.97 · 2008 · External reference
Discovery and structure - activity relationships of - aminoquinazoline derivatives , a novel class of opioid receptor like - antagonists Bioorganic
10.1016/j.bmc.2008.11.012.http://dx.doi.org/10.1016/j.bmc.2008.11.012 · 2009 · External reference
Homology modeling and molecular dynamics simulations of the active state of the nociceptin receptor reveal new insights into agonist binding and activation Proteins : Structure , Function , and
10.1002/prot.24077 · 2012 · External reference
The nociceptin / orphanin FQ receptor : A target with broad therapeutic potential :
10.1038/nrd2572 · 2008 · External reference
Spare interactions of highly potent Arg nociceptin for cooperative induction of ORL receptor activation Bioorganic
10.1016/j.bmc.2009.10.026.http://dx.doi.org/10.1016/j.bmc.2009.10.026 · 2009 · External reference
Design , synthesis and structure - activity relationship study of a novel class of ORL receptor antagonists based on N - biarylmethyl spiropiperidine Bioorganic
10.1016/j.bmcl.2008.05.036.http://dx.doi.org/10.1016/j.bmcl.2008.05.036 · 2008 · External reference
Molecular modelling studies on the ORL - receptor and ORL - agonists of Computer -
10.1023/b:jcam.0000017491.97244.69.http://dx.doi.org/10.1023/b:jcam.0000017491.97244.69 · 2003 · External reference
MOPAC computer software Colorado Springs CO Stewart Computational Chemistry
2008 · External reference
Comparative protein modeling by satisfaction of spatial restraints
10.1006/jmbi.1993.1626.http://dx.doi.org/10.1006/jmbi.1993.1626 · 1993 · External reference
Validation of the general purpose QUANTA CHARMm force field
10.1002/jcc.54013074.http://dx.doi.org/10.1002/jcc.540130714 · 1992 · External reference
Fast , scalable generation of high - quality protein multiple sequence alignments using Clustal Omega
10.1038/msb.2011.75.http://dx.doi.org/10.1038/msb.2011.75 · 2011 · External reference
The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays
10.1016/j.febslet.2011.10.027.http://dx.doi.org/10.1016/j.febslet.2011.10.027 · 2011 · External reference
Structure of the nociceptin / orphanin FQ receptor in complex with a peptide mimetic
10.1038/nature11085.http://dx.doi.org/10.1038/nature11085 · 2012 · External reference
Address and message sequences for the nociceptin receptor : A structure - activity study of nociceptin - ( peptide amide
10.1021/jm970011b.http://dx.doi.org/10.1021/jm970011b · 1997 · External reference
Structure of a nanobodystabilized active state of the β - adrenoceptor
10.1038/nature09648.http://dx.doi.org/10.1038/nature09648 · 2011 · External reference
AutoDock Vina : Improving the speed and accuracy of docking with a new scoring function , efficient optimization and multithreading
10.1002/jcc.21334 · 2010 · External reference
Avogadro : An advanced semantic chemical editor , visualization and analysis platform of
10.1186/1758-2946-4-17.http://dx.doi.org/10.1186/1758-2946-4-17 · 2012 · External reference
General atomic and molecular electronic structure system
10.1002/jcc.540141112.http://dx.doi.org/10.1002/jcc.540141112 · 1993 · External reference
High - resolution crystal structure of an engineered human β - adrenergic G - protein - coupled receptor
10.1126/science.1150577.http://dx.doi.org/10.1126/science.1150577 · 2007 · External reference
PROCHECK : A program to check the stereochemical quality of protein structures
10.1107/s0021889892009944.http://dx.doi.org/10.1107/s0021889892009944 · 1993 · External reference
