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References from SPIKE PROTEIN AND ITS PROTEASES ROLE IN SARS-COV-2 PATHOGENICITY AND TREATMENT; A REVIEW. Local targets link to admitted publications; unresolved targets remain external evidence.
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Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells
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The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
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SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor
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Sequence and topology of a model intracellular membrane protein, E1 glycoprotein, from a coronavirus
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Coronavirus Particle Assembly: Primary Structure Requirements of the Membrane Protein
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Coronavirus Genomics and Bioinformatics Analysis
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TGEV corona virus ORF4 encodes a membrane protein that is incorporated into virions
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A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
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Protease inhibitors targeting coronavirus and filovirus entry
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Production of trimeric SARS-CoV-2 spike protein by CHO cells for serological COVID-19 testing
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Glycosylation of viral surface proteins probed by mass spectrometry
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10.1016/j.bbrc.2020.02.071
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Structure, Function, and Evolution of Coronavirus Spike Proteins
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Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2
10.1002/jmv.25726 · 2020 · External reference
SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
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The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism
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Evidence for a coiled-coil structure in the spike proteins of coronaviruses
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Interaction of SARS-CoV-2 and other Coronavirus with ACE (Angiotensin-Converting Enzyme)-2 as their main receptor: therapeutic implications
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An updated insight into the molecular pathogenesis, secondary complications and potential therapeutics of COVID-19 pandemic
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Deduced sequence of the bovine coronavirus spike protein and identification of the internal proteolytic cleavage site
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Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects
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Primary structure of the glycoprotein E2 of coronavirus MHV-A59 and identification of the trypsin cleavage site
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10.1016/j.lfs.2020.118105
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The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
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10.1016/j.mayocp.2020.03.026
10.1016/j.mayocp.2020.03.026 · External reference
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A cellular census of human lungs identifies novel cell states in health and in asthma
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Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry
10.1073/pnas.0711241105 · 2008 · External reference
Angiotensin-converting enzyme 2 protects from severe acute lung failure
10.1038/nature03712 · 2005 · External reference
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
10.1038/nm1267 · 2005 · External reference
Is the ACE2 Overexpression a Risk Factor for COVID-19 Infection
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Unresolved reference
External reference
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Sex Drives Dimorphic Immune Responses to Viral Infections
10.4049/jimmunol.1601166 · 2017 · External reference
Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men
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Landscape of X chromosome inactivation across human tissues
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Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2
10.1128/jvi.01890-13 · 2013 · External reference
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Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis
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Unresolved reference
External reference
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Hepatocellular carcinoma in hereditary tyrosinemia type I despite 2-(2 nitro-4-3 trifluoro-methylbenzoyl)-1, 3-cyclohexanedione treatment
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Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure
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10.1128/jvi.01815-18 · External reference
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Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites
10.1073/pnas.0809524106 · 2009 · External reference
Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry
10.1016/j.virol.2006.02.003 · 2006 · External reference
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
10.1093/cid/ciaa237 · 2020 · External reference
A new proposed mechanism of some known drugs targeting the sars-cov-2 spike glycoprotein using molecular docking
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Arbidol as a broad-spectrum antiviral: an update
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Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
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Family-wide Structural Analysis of Human Numb-Associated Protein Kinases
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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
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