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References from <i>In silico</i> identification and action mechanism of potential sleep-promoting peptides from egg proteins. Local targets link to admitted publications; unresolved targets remain external evidence.
How broken sleep promotes cardiovascular disease
10.1038/d41586-019-00393-6 · 2019 · External reference
Statistical analysis of the effect of simulation time on the results of molecular dynamics studies of food proteins: a study of the Ara h 6 peanut protein
10.3390/pr13020581 · 2025 · External reference
Effect of a dual orexin receptor antagonist on Alzheimer’s disease: sleep disorders and cognition
10.3389/fmed.2022.984227 · 2023 · External reference
Sleep and mental disorders: a meta-analysis of polysomnographic research
10.1037/bul0000053 · 2016 · External reference
Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in rodent model
10.1039/c9fo02248a · 2020 · External reference
Insomnia and benzodiazepine use as risk factors for erectile dysfunction: clinical evidence and in silico analysis of physicochemical properties
10.3390/jcm14196951 · 2025 · External reference
Identification and screening of potential bioactive peptides with sleep-enhancing effects in bovine milk casein hydrolysate
10.1021/acs.jafc.1c03937 · 2021 · External reference
Structure, function, and modulation of GABAA receptor
10.1074/jbc.r112.386664 · 2012 · External reference
Enhancement of pentobarbital-induced sleep by apigenin through chloride ion channel activation
10.1007/s12272-012-0218-4 · 2012 · External reference
10.1016/j.neuropharm.2018.01.036
10.1016/j.neuropharm.2018.01.036 · External reference
Sleep state switching
10.1016/j.neuron.2010.11.032 · 2010 · External reference
Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions
10.1523/jneurosci.1205-09.2009 · 2009 · External reference
Mechanism for hypocretin-mediated sleep-to-wake transitions
10.1073/pnas.1202526109 · 2012 · External reference
Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep
10.1523/jneurosci.6506-10.2011 · 2011 · External reference
Identification and exploration of sleep-enhancing peptides from goat milk casein by peptidomics and virtual screening
10.1016/j.foodres.2025.117333 · 2025 · External reference
Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity
10.1073/pnas.2214171120 · 2023 · External reference
Enhanced antibacterial activity of hen egg-white lysozyme against Staphylococcus aureus and Escherichia coli due to protein fibrillation
10.1021/acs.biomac.0c01599 · 2021 · External reference
10.1038/s41538-018-0015-7 · 2018 · Admitted local publication
Potential antihypertensive mechanisms of the egg white-derived peptide QIGLF in spontaneously hypertensive rats revealed using untargeted serum metabolomics
10.1021/acs.jafc.1c05599 · 2021 · External reference
Experimental protocols used to mimic gastrointestinal protein digestion: a systematic review
10.3390/nu16152398 · 2024 · External reference
Applications of molecular dynamics simulation in protein study
10.3390/membranes12090844 · 2022 · External reference
Identification of tuna protein-derived peptides as potent SARS-CoV-2 inhibitors via molecular docking and molecular dynamic simulation
10.1016/j.foodchem.2020.128366 · 2020 · External reference
Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology
10.1038/s41586-023-06556-w · 2023 · External reference
Food-derived bioactive peptides for anxiety and sleep management: mechanistic insights, bidirectional interactions, structure-activity relationship, and targeted preparation
10.1016/j.tifs.2025.105468 · 2025 · External reference
Binding site opening by loop C shift and chloride ion-pore interaction in the GABAA receptor model
10.1039/c7cp00582b · 2017 · External reference
10.1038/s42003-022-03720-2
10.1038/s42003-022-03720-2 · External reference
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation
10.1038/s41467-021-21087-6 · 2021 · External reference
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors
10.1038/nsmb.3183 · 2016 · External reference
Computational studies on horseshoe shape pocket of human orexin receptor type 2 and boat conformation of suvorexant by molecular dynamics simulations
10.1111/cbdd.13181 · 2018 · External reference
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic
10.1038/nature11085 · 2012 · External reference
Nociceptin/orphanin FQ peptide (NOP) receptor modulators: an update in structure-activity relationships
10.2174/0929867325666180111095458 · 2018 · External reference
Biased agonism at nociceptin/orphanin FQ receptors: a structure activity study on N/OFQ(1-13)-NH2
10.1021/acs.jmedchem.9b02057 · 2020 · External reference
Pharmacological profile of nociceptin/orphanin FQ receptors interacting with G-proteins and β-arrestins 2
10.1371/journal.pone.0132865 · 2015 · External reference
10.1002/dneu.22536
10.1002/dneu.22536 · External reference
Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation
10.1016/j.tips.2010.10.001 · 2011 · External reference
Structural insights into agonist-induced activation of G-protein-coupled receptors
10.1016/j.sbi.2011.06.002 · 2011 · External reference
Determination of hydrogen bonds in GROMACS: a new implementation to overcome memory limitation
10.1021/acs.jcim.3c02087 · 2024 · External reference
Molecular dynamic simulation of the porcine pancreatic lipase in non-aqueous organic solvents
10.3389/fbioe.2020.00676 · 2020 · External reference
