Research graph
References from The extract of <i>Polygonum capitatum</i> alleviates hyperoxaluria-induced oxidative stress by targeting the PI3K-ERK-NRF2 signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Kidney stone prevention
10.1016/j.advnut.2023.03.002 · 2023 · External reference
Determining the true burden of kidney stone disease
10.1038/s41581-020-0320-7 · 2020 · External reference
Kidney stones
10.1038/nrdp.2016.8 · 2016 · External reference
Oxalate as a potent promoter of kidney stone formation
10.3389/fmed.2023.1159616 · 2023 · External reference
Oxalate metabolism: from kidney stones to cardiovascular disease
10.1016/j.mayocp.2024.02.006 · 2024 · External reference
Cerium oxide-based nanozyme suppresses kidney calcium oxalate crystal depositions via reversing hyperoxaluria-induced oxidative stress damage
10.1186/s12951-022-01726-w · 2022 · External reference
DUSP2-mediated inhibition of tubular epithelial cell pyroptosis confers nephroprotection in acute kidney injury
10.7150/thno.72291 · 2022 · External reference
Oxalate disrupts monocyte and macrophage cellular function via interleukin-10 and mitochondrial reactive oxygen species (ROS) signaling
10.1016/j.redox.2023.102919 · 2023 · External reference
Oxalate-induced apoptosis through ERS-ROS-NF-κ B signaling pathway in renal tubular epithelial cell
10.1186/s10020-022-00494-5 · 2022 · External reference
High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction
10.1038/s41419-020-03122-4 · 2020 · External reference
miR-155-5p promotes oxalate- and calcium-induced kidney oxidative stress injury by suppressing mgp expression
10.1097/ju.0000000000001112.03 · 2020 · External reference
Expression of heterologous oxalate decarboxylase in HEK293 cells confers protection against oxalate induced oxidative stress as a therapeutic approach for calcium oxalate stone disease
10.1080/14756366.2016.1256884 · 2017 · External reference
Lycopene from tomatoes and tomato products exerts renoprotective effects by ameliorating oxidative stress, apoptosis, pyroptosis, fibrosis, and inflammatory injury in calcium oxalate nephrolithiasis: the underlying mechanisms
10.1039/d4fo00042k · 2024 · External reference
H2S exposure-induced oxidative stress promotes LPS-mediated hepatocyte autophagy through the PI3K/AKT/TOR pathway
10.1016/j.ecoenv.2020.111801 · 2021 · External reference
FGL2 deficiency alleviates maternal inflammation-induced blood-brain barrier damage by blocking PI3K/NF-к B mediated endothelial oxidative stress
10.3389/fimmu.2023.1157027 · 2023 · External reference
Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
10.1038/s12276-024-01180-8 · 2024 · External reference
PI3K signaling: the path to discovery and understanding
10.1038/nrm3290 · 2012 · External reference
ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials
10.1186/s12989-024-00562-0 · 2024 · External reference
Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3beta signaling pathway
10.1016/j.biopha.2018.11.103 · 2019 · External reference
Reactive oxygen species as the molecular modulators of calcium oxalate kidney stone formation: evidence from clinical and experimental investigations
10.1016/j.juro.2012.05.078 · 2013 · External reference
Calcium oxalate stone disease: role of lipid peroxidation and antioxidants
10.1007/s00240-001-0228-z · 2002 · External reference
Unresolved reference
2010 · External reference
Unresolved reference
2016 · External reference
Effect of hot leaching granules on postoperative stone expulsion effect and urinary tract infection in patients with kidney stones
10.13638/j.issn.1671-4040.2021.21.017 · 2021 · External reference
Observation of the effects of hot leaching granules on the prevention of urinary tract infection after kidney stone surgery, and the effects of stone induction and pain relief
10.13193/j.issn.1673-7717.2017.03.073 · 2017 · External reference
New biomarkers in acute kidney injury
10.1080/10408363.2023.2242481 · 2024 · External reference
Sulfide: quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells
10.1016/j.redox.2023.102973 · 2024 · External reference
Myricetin attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models
10.4155/fmc-2018-0172 · 2018 · External reference
The protective effects of myricetin against cardiovascular disease
10.3177/jnsv.65.470 · 2019 · External reference
Myricetin ameliorates ethanol-induced lipid accumulation in liver cells by reducing fatty acid biosynthesis
10.1002/mnfr.201801393 · 2019 · External reference
Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice
10.1080/13880209.2016.1275704 · 2017 · External reference
Myricitrin modulates NADPH oxidase-dependent ROS production to inhibit endotoxin-mediated inflammation by blocking the JAK/STAT1 and NOX2/p47(phox) pathways
10.1155/2017/9738745 · 2017 · External reference
Systems pharmacology dissection of the protective effect of myricetin against acute ischemia/reperfusion-induced myocardial injury in isolated rat heart
10.1007/s12012-016-9382-y · 2017 · External reference
Myricetin alleviates pathological cardiac hypertrophy via TRAF6/TAK1/MAPK and Nrf2 signaling pathway
10.1155/2019/6304058 · 2019 · External reference
The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis
10.1016/j.ijbiomac.2019.11.075 · 2020 · External reference
Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-к B and SIRT6/NF-к B pathway
10.1002/jor.25573 · 2023 · External reference
Orientin mediates protection against MRSA-induced pneumonia by inhibiting sortase A
10.1080/21505594.2021.1962138 · 2021 · External reference
Kaempferol exerts antioxidant effects in age-related diminished ovarian reserve by regulating the HSP90/NRF2 pathway
10.1111/cbdd.14385 · 2024 · External reference
Kaempferol improves exercise performance by regulating glucose uptake, mitochondrial biogenesis, and protein synthesis via PI3K/AKT and MAPK signaling pathways
10.3390/foods13071068 · 2024 · External reference
α-Ketoglutarate attenuates hyperlipidemia-induced endothelial damage by activating the Erk-Nrf2 signaling pathway to inhibit oxidative stress and mitochondrial dysfunction
10.1089/ars.2022.0215 · 2023 · External reference
Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo
10.1007/s10495-022-01770-9 · 2022 · External reference
Orientin promotes antioxidant capacity, mitochondrial biogenesis, and fiber transformation in skeletal muscles through the AMPK pathway
10.1021/acs.jafc.3c08039 · 2024 · External reference
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
10.1074/jbc.r900010200 · 2009 · External reference
Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress
10.1016/j.jare.2021.06.023 · 2021 · External reference
Modulation of Nrf2/HO-1 by natural compounds in lung cancer
10.3390/antiox12030735 · 2023 · External reference
Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway
10.1039/c9fo01152h · 2019 · External reference
Hypoglycemic and antioxidant properties of extracts and fractions from Polygoni Avicularis herba
10.3390/molecules27113381 · 2022 · External reference
Total phenolics and antioxidant activity of Piper auritum and Porophyllum ruderale
10.1016/j.foodchem.2013.07.078 · 2014 · External reference
Kaempferol and atherosclerosis: from mechanism to medicine
10.1080/10408398.2022.2121261 · 2024 · External reference
Kaempferol: paving the path for advanced treatments in aging-related diseases
10.1016/j.exger.2024.112389 · 2024 · External reference
Ellagic acid and its anti-aging effects on central nervous system
10.3390/ijms231810937 · 2022 · External reference
The multifaceted mechanisms of ellagic acid in the treatment of tumors: state-of-the-art
10.1016/j.biopha.2023.115132 · 2023 · External reference
Toxicological effects of deltamethrin on quail cerebrum: weakened antioxidant defense and enhanced apoptosis
10.1016/j.envpol.2021.117319 · 2021 · External reference
The link between deacetylation and hepatotoxicity induced by exposure to hexavalent chromium
10.1016/j.jare.2021.04.002 · 2022 · External reference
Oxidative stress and inflammation: what polyphenols can do for us?
10.1155/2016/7432797 · 2016 · External reference
Hypoxia, oxidative stress and inflammation
10.1016/j.freeradbiomed.2018.03.042 · 2018 · External reference
Role of inflammation, immunity, and oxidative stress in hypertension: new insights and potential therapeutic targets
10.3389/fimmu.2022.1098725 · 2022 · External reference
Dihydromyricetin enhances intestinal antioxidant capacity of growing-finishing pigs by activating ERK/Nrf2/HO-1 signaling pathway
10.3390/antiox11040704 · 2022 · External reference
ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress
10.1186/s12906-019-2551-3 · 2019 · External reference
