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References from Constipation targeted monostrain and multispecies probiotics: effects on symptoms and gut microbiota. Local targets link to admitted publications; unresolved targets remain external evidence.
The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
10.1038/nrgastro.2014.66 · 2014 · External reference
Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit
10.3748/wjg.v22.i21.5122 · 2016 · External reference
Effectiveness of multi-strain versus single-strain probiotics current status and recommendations for the future
10.1097/mcg.0000000000001052 · 2018 · External reference
Probiotics and synbiotics in chronic constipation in adults: a systematic review and meta-analysis of randomized controlled trials
10.1016/j.clnu.2022.10.015 · 2022 · External reference
Benefits of multistrain bacteria formulations for health
10.1016/j.jff.2018.05.051 · 2018 · External reference
Monostrain, multistrain and multispecies problotics - a comparison of functionality and efficacy
10.1016/j.ijfoodmicro.2004.05.012 · 2004 · External reference
Chronic constipation
10.1038/nrdp.2017.95 · 2017 · External reference
The cost of constipation, Lancet Gastroenterol
10.1016/s2468-1253(19)30297-3 · 2019 · External reference
Global prevalence of functional constipation according to the Rome criteria: a systematic review and meta-analysis
10.1016/s2468-1253(21)00111-4 · 2021 · External reference
Epidemiology of constipation in elderly people in parts of China: a multicenter study
10.3389/fpubh.2022.823987 · 2022 · External reference
The magnitude and management of functional constipation at pediatric gastroenterology clinics: a survey study of various countries
10.1111/jgh.15671 · 2022 · External reference
Impact of chronic constipation on health-related quality of life, work productivity, and healthcare resource use: an analysis of the national health and wellness survey
10.1007/s10620-011-1639-5 · 2011 · External reference
Economic and humanistic burden of chronic constipation
10.14309/00000434-201010001-01081 · 2010 · External reference
Role of gut microbiota in functional constipation
10.1093/gastro/goab035 · 2021 · External reference
The intestinal ecosystem in chronic functional constipation
10.1080/080352598750013590 · 1998 · External reference
Alterations in the colonic flora and intestinal permeability and evidence of immune activation in chronic constipation
10.1016/j.dld.2005.06.008 · 2005 · External reference
Mucosa-associated gut microbiome in Japanese patients with functional constipation
10.3164/jcbn.20-93 · 2021 · External reference
Methanogenic flora is associated with altered colonic transit but not stool characteristics in constipation without IBS
10.1038/ajg.2009.655 · 2010 · External reference
Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation
10.1053/j.gastro.2015.10.005 · 2016 · External reference
10.1007/164_2016_111
10.1007/164_2016_111 · External reference
Chronic idiopathic constipation sufferers and treatment satisfaction: prescription vs. over-the-counter medications
10.1016/s0016-5085(22)62192-9 · 2022 · External reference
Chronic constipation: a survey of the patient perspective
10.1111/j.1365-2036.2006.03238.x · 2007 · External reference
Probiotics and constipation: mechanisms of action, evidence for effectiveness and utilisation by patients and healthcare professionals
10.1017/s0029665119000934 · 2020 · External reference
Viral infections, the microbiome, and probiotics
10.3389/fcimb.2020.596166 · 2020 · External reference
Prebiotics and probiotics in digestive health
10.1016/j.cgh.2018.09.028 · 2019 · External reference
Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion
10.1002/mnfr.201801187 · 2019 · External reference
Mechanisms of action of probiotics and the gastrointestinal microbiota on gut motility and constipation
10.3945/an.116.014407 · 2017 · External reference
Meta-analysis of randomized controlled trials of the effects of probiotics on functional constipation in adults
10.1016/j.clnu.2020.01.005 · 2020 · External reference
The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials
10.3945/ajcn.114.089151 · 2014 · External reference
Are probiotics useful in the treatment of chronic idiopathic constipation in adults? a review of existing systematic reviews, meta-analyses, and recommendations
10.5114/pg.2019.86747 · 2020 · External reference
Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials
10.1186/s13073-016-0300-5 · 2016 · External reference
Efficacy and safety of probiotics and synbiotics for functional constipation in children: a systematic review and meta-analysis of randomized clinical trials
10.1016/j.clnu.2023.08.015 · 2023 · External reference
Cochrane handbook for systematic reviews of interventions
2019 · External reference
PRISMA-S: an extension to the PRISMA statement for reporting literature searches in systematic reviews
10.1186/s13643-020-01542-z · 2021 · External reference
The cochrane collaboration’s tool for assessing risk of bias in randomised trials
10.1136/bmj.d5928 · 2011 · External reference
Bias in meta-analysis detected by a simple, graphical test
10.1136/bmj.315.7109.629 · 1997 · External reference
Effect of multispecies probiotic on gut microbiota composition in individuals with intestinal constipation: a double-blind, placebo-controlled randomized trial
10.1016/j.nut.2020.110890 · 2020 · External reference
Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation
10.1111/apt.15073 · 2019 · External reference
Spore-forming Bacillus coagulans SNZ 1969 improved intestinal motility and constipation perception mediated by microbial alterations in healthy adults with mild intermittent constipation: a randomized controlled trial
10.1016/j.foodres.2021.110428 · 2021 · External reference
A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation
10.1039/d1fo03896f · 2022 · External reference
Lactobacillus plantarum Lp3a improves functional constipation: evidence from a human randomized clinical trial and animal model
10.21037/atm-22-458 · 2022 · External reference
The effect of Lactobacillus reuteri supplementation in adults with chronic functional constipation: a randomized, double-blind, placebo-controlled trial
10.15403/jgld.2014.1121.234.elr · 2014 · External reference
Effects of probiotic use on quality of life and physical activity in constipated female university students: a randomized, double-blind placebo-controlled study
10.1089/acm.2019.0134 · 2019 · External reference
Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: a double-blind, randomized, placebo-controlled, and dose-ranging trial
10.1080/19490976.2017.1412908 · 2018 · External reference
Effect of the probiotic strain, Lactiplantibacillus plantarum P9, on chronic constipation: a randomized, double-blind, placebo-controlled study
10.1016/j.phrs.2023.106755 · 2023 · External reference
Personalized probiotic strategy considering bowel habits: impacts on gut microbiota composition and alleviation of gastrointestinal symptoms via Consti-Biome and Sensi-Biome
10.3389/fnut.2024.1302093 · 2024 · External reference
The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial
10.1038/s41430-022-01189-0 · 2022 · External reference
Usefulness of Bifidobacterium longum BB536 in elderly individuals with chronic constipation: a randomized controlled trial
10.14309/ajg.0000000000002028 · 2023 · External reference
Effects of intake of Lactococcus cremoris subsp. cremoris FC on constipation symptoms and immune system in healthy participants with mild constipation: a double-blind, placebo-controlled study
10.1080/09637486.2023.2236805 · 2023 · External reference
Bacillus coagulans Unique IS2 in constipation: a double-blind, placebo-controlled study
10.1007/s12602-019-09542-9 · 2020 · External reference
Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans
10.1016/j.jbiosc.2011.12.016 · 2012 · External reference
Probiotic supplementation decreases intestinal transit time: meta-analysis of randomized controlled trials
10.3748/wjg.v19.i29.4718 · 2013 · External reference
Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta-analysis
10.1111/apa.12513 · 2014 · External reference
Gut microbiota and the use of probiotics in constipation in children and adolescents: systematic review
10.1590/1984-0462/2020/38/2018123 · 2020 · External reference
Probiotics for treatment of chronic constipation in children
10.1002/14651858.cd014257.pub2 · 2022 · External reference
Nonpharmacologic treatment for children with functional constipation: a systematic review and meta-analysis
10.1016/j.jpeds.2021.09.010 · 2022 · External reference
Gut microbiota alterations from different Lactobacillus probiotic-fermented yoghurt treatments in slow-transit constipation
10.1016/j.jff.2017.08.037 · 2017 · External reference
Dietary fibre in gastrointestinal health and disease
10.1038/s41575-020-00375-4 · 2021 · External reference
Bifidobacterium animalis subsp. lactis HN019 effects on gut health: a review
10.3389/fnut.2021.790561 · 2021 · External reference
Bifidobacterium animalis subsp. lactis HN019 effects on gut health: a review
10.3389/fnut.2021.790561 · 2021 · External reference
Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults
10.3109/00365521.2011.584895 · 2011 · External reference
Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain-a randomised clinical study
10.1111/apt.12800 · 2014 · External reference
Multi-Strain probiotics: synergy among isolates enhances biological activities
10.3390/biology10040322 · 2021 · External reference
Prebiotic preferences of human lactobacilli strains in co-culture with bifidobacteria and antimicrobial activity against Clostridium difficile
10.1111/jam.12953 · 2015 · External reference
The mucus binding of Bifidobacterium lactis Bb12 is enhanced in the presence of Lactobacillus GG and Lact. delbrueckii subsp. bulgaricus
10.1046/j.1472-765x.2000.00590.x · 2000 · External reference
Microcalorimetric evaluation of a multi-strain probiotic: interspecies inhibition between probiotic strains
10.1016/j.jff.2017.07.018 · 2017 · External reference
A Mesocosm of Lactobacillus johnsonii, Bifidobacterium longum, and Escherichia coli in the mouse gut
10.1089/dna.2009.0873 · 2009 · External reference
Screening microbial interactions during inulin utilization reveals strong competition and proteomic changes in Lacticaseibacillus paracasei M38
10.1007/s12602-023-10083-5 · 2023 · External reference
In vitro evaluation of single- and multi-strain probiotics: inter-species inhibition between probiotic strains, and inhibition of pathogens
10.1016/j.anaerobe.2012.05.004 · 2012 · External reference
Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat
10.1152/ajpgi.1998.275.6.g1415 · 1998 · External reference
Motor effects of short-chain fatty acids and lactate in the gastrointestinal tract
10.1079/pns2002213 · 2003 · External reference
Lactulose, lactic acid bacteria, intestinal microecology and mucosal protection
10.1080/00365521.1997.11720717 · 1997 · External reference
Fermentation of polysaccharides and absorption of short chain fatty-acids in the mammalian hindgut
10.1016/0300-9629(88)90668-8 · 1988 · External reference
Prospective, randomized, parallel-group trial to evaluate the effects of lactulose and polyethylene glycol-4000 on colonic flora in chronic idiopathic constipation
10.1111/j.1365-2036.2004.01918.x · 2004 · External reference
Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome
10.1111/j.1365-2036.2012.05007.x · 2012 · External reference
Analysis of gut microbiome and metabolite characteristics in patients with slow transit constipation
10.1007/s10620-020-06500-2 · 2021 · External reference
Structural changes in the gut microbiome of constipated patients
10.1152/physiolgenomics.00082.2014 · 2014 · External reference
Systematic review: probiotics for functional constipation in children
10.1007/s00431-017-2972-2 · 2017 · External reference
Bile salt hydrolase activity in probiotics
10.1128/aem.72.3.1729-1738.2006 · 2006 · External reference
Interactions between commensal bacteria and gut sensorimotor function in health and disease
10.1111/j.1572-0241.2005.00230.x · 2005 · External reference
Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats
10.1152/ajpregu.00442.2002 · 2003 · External reference
Crosstalk between the gut microbiome and colonic motility in chronic constipation: potential mechanisms and microbiota modulation
10.3390/nu14183704 · 2022 · External reference
Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon
10.1016/0016-5085(89)91614-4 · 1989 · External reference
Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome
10.1111/j.1365-2982.2012.01893.x · 2012 · External reference
The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
10.1053/j.gastro.2012.09.055 · 2013 · External reference
Gut microbiota-motility interregulation: insights from in vivo, ex vivo and in silico studies
10.1080/19490976.2021.1997296 · 2022 · External reference
10.1007/978-1-4939-7534-1_6
10.1007/978-1-4939-7534-1_6 · External reference