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References from Comprehensive utility of milk and dairy products in colorectal cancer prevention and treatment: insights from a single ingredient to a holistic dietary strategy—a review. Local targets link to admitted publications; unresolved targets remain external evidence.
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Lactoferrin: a nutraceutical with activity against colorectal cancer
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Unlocking the potential of milk whey protein components in colorectal cancer prevention and therapy
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Dairy products and cancer
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Goat and buffalo milk fat globule membranes exhibit better effects at inducing apoptosis and reduction the viability of HT-29 cells
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Does structure affect biological function? modifications to the protein and phospholipids fraction of the milk fat globule membrane after extraction affect the antiproliferative activity of colon cancer cells
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Prediagnostic intake of dairy products and dietary calcium and colorectal cancer survival-results from the EPIC cohort study
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Calcium, vitamin D, dairy products, and mortality among colorectal cancer survivors: the Cancer Prevention Study-Ⅱ Nutrition Cohort
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Associations of calcium, vitamin D, and dairy product intakes with colorectal cancer risk among older women: The Iowa Women’s Health Study
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Associations of calcium and dairy product intakes with all-cause, all-cancer, colorectal cancer and CHD mortality among older women in the Iowa Women’s Health Study
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Calcium and vitamin D and risk of colorectal cancer: results from a large population-based case-control study in Newfoundland and Labrador and Ontario
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Higher intakes of dietary vitamin D, calcium and dairy products are inversely associated with the risk of colorectal cancer: a case-control study in China
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Inflammation modulation by vitamin D and calcium in the morphologically normal colorectal mucosa of patients with colorectal adenoma in a clinical trial
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Calcium and dairy products in the chemoprevention of colorectal adenomas: a systematic review and meta-analysis
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Effects of calcium and vitamin D3 on transforming growth factors in rectal mucosa of sporadic colorectal adenoma patients: a randomized controlled trial
10.1002/mc.22096 · 2015 · External reference
Effects of vitamin D and calcium on expression of MSH2 and transforming growth factors in normal-appearing colorectal mucosa of sporadic colorectal adenoma patients: a randomized clinical trial
10.1002/mc.22945 · 2019 · External reference
Effects of supplemental calcium and vitamin D on the APC/β-catenin pathway in the normal colorectal mucosa of colorectal adenoma patients
10.1002/mc.22504 · 2017 · External reference
Associations of intakes of total protein, protein from dairy sources, and dietary calcium with risks of colorectal, breast, and prostate cancer: a prospective analysis in UK Biobank
10.1038/s41416-023-02339-2 · 2023 · External reference
Potential anticarcinogenic effect of goat milk-derived bioactive peptides on HCT-116 human colorectal carcinoma cell line
10.1016/j.ab.2021.114166 · 2021 · External reference
Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma
10.1038/s41598-021-86391-z · 2021 · External reference
Consistent signatures in the human gut microbiome of old- and young-onset colorectal cancer
10.1038/s41467-024-47523-x · 2024 · External reference
Impact of novel prebiotic galacto-oligosaccharides on various biomarkers of colorectal cancer in Wister rats
10.3390/ijms18091785 · 2017 · External reference
A galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal model
10.3389/fmicb.2018.02004 · 2018 · External reference
Lactulose modulates the structure of gut microbiota and alleviates colitis-associated tumorigenesis
10.3390/nu14030649 · 2022 · External reference
Human milk oligosaccharides: shaping the infant gut microbiota and supporting health
10.1016/j.jff.2020.104074 · 2020 · External reference
Oral supplementation of healthy adults with 2'-O-fucosyllactose and lacto-N-neotetraose is well tolerated and shifts the intestinal microbiota
10.1017/s0007114516003354 · 2016 · External reference
Effects of human milk oligosaccharides on the adult gut microbiota and barrier function
10.3390/nu12092808 · 2020 · External reference
The effects of human milk oligosaccharides on gut microbiota, metabolite profiles and host mucosal response in patients with irritable bowel syndrome
10.3390/nu13113836 · 2021 · External reference
Galactooligosaccharides as a protective agent for intestinal barrier and its regulatory functions for intestinal microbiota
10.1016/j.foodres.2022.111003 · 2022 · External reference
Human milk oligosaccharides increase mucin expression in experimental necrotizing enterocolitis
10.1002/mnfr.201800658 · 2019 · External reference
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota
10.7150/thno.62046 · 2021 · External reference
Cow and human milk-derived exosomes ameliorate colitis in DSS murine model
10.3390/nu12092589 · 2020 · External reference
Milk exosomal miR-27b worsen endoplasmic reticulum stress mediated colorectal cancer cell death
10.3390/nu14235081 · 2022 · External reference
Bovine milk-derived exosomes enhance goblet cell activity and prevent the development of experimental necrotizing enterocolitis
10.1371/journal.pone.0211431 · 2019 · External reference
Human breast milk-derived exosomes may help maintain intestinal epithelial barrier integrity
10.1038/s41390-021-01449-y · 2021 · External reference
Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis
10.1126/sciadv.ade5041 · 2023 · External reference
Bovine lactoferrin protects dextran sulfate sodium salt mice against inflammation and impairment of colonic epithelial barrier by regulating gut microbial structure and metabolites
10.3389/fnut.2021.660598 · 2021 · External reference
Early-life lactoferrin intervention modulates the colonic microbiota, colonic microbial metabolites and intestinal function in suckling piglets
10.1007/s00253-020-10675-z · 2020 · External reference
A holistic review of the state-of-the-art microfluidics for exosome separation: an overview of the current status, existing obstacles, and future outlook
10.1002/smll.202007174 · 2021 · External reference
Caseinophosphopeptides exert partial and site-specific cytoprotection against H2O2-induced oxidative stress in Caco-2 cells
10.1016/j.foodchem.2011.05.129 · 2011 · External reference
The effectiveness of whey proteins in prevention and treatment of cancer: a review
10.1080/10408398.2022.2121256 · 2024 · External reference
Lactoferrin exerts antitumor effects by inhibiting angiogenesis in a HT29 human colon tumor model
10.1021/acs.jafc.7b03390 · 2017 · External reference
Lactoferrin inhibits the development of T2D-induced colon tumors by regulating the NT5DC3/PI3K/AKT/mTOR signaling pathway
10.3390/foods11243956 · 2022 · External reference
Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m(6)A/NT5DC3/HKDC1 axis
10.1186/s12967-023-03983-1 · 2023 · External reference
Total vitamin D intake and risks of early-onset colorectal cancer and precursors
10.1053/j.gastro.2021.07.002 · 2021 · External reference
Epigenetic silencing of CYP24 in tumor-derived endothelial cells contributes to selective growth inhibition by calcitriol
10.1074/jbc.m608894200 · 2007 · External reference
1α,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells
10.1038/sj.onc.1208801 · 2005 · External reference
Identification of a ferroptosis-related gene signature for prognosis prediction in colorectal cancer patients and relationship with vitamin D
10.1016/j.jsbmb.2022.106234 · 2023 · External reference
Association of DNA methylation of vitamin D metabolic pathway related genes with colorectal cancer risk
10.1186/s13148-023-01555-0 · 2023 · External reference
Milk-derived exosomes as nanocarriers to deliver curcumin and resveratrol in breast tissue and enhance their anticancer activity
10.3390/ijms23052860 · 2022 · External reference
Curcumin encapsulated in milk exosomes resists human digestion and possesses enhanced intestinal permeability in vitro
10.1007/s12010-017-2478-4 · 2017 · External reference
Milk-derived exosomes for oral delivery of paclitaxel
10.1016/j.nano.2017.03.001 · 2017 · External reference
Cow milk and intestinal epithelial cell-derived extracellular vesicles as systems for enhancing oral drug delivery
10.3390/pharmaceutics12030226 · 2020 · External reference
Lactoferrin-dual drug nanoconjugate: synergistic anti-tumor efficacy of docetaxel and the NF-κB inhibitor celastrol
10.1016/j.msec.2020.111422 · 2021 · External reference
Synergistic action of lactoferrin in enhancing the safety and effectiveness of docetaxel treatment against prostate cancer
10.1007/s00280-023-04524-9 · 2023 · External reference
Engineered microencapsulated lactoferrin nanoconjugates for oral targeted treatment of colon cancer
10.1021/acs.biomac.3c00037 · 2023 · External reference
Prospective study on milk products, calcium and cancers of the colon and rectum
10.1038/sj.ejcn.1601260 · 2001 · External reference
Calcium and vitamin D intake and risk of colorectal cancer: the Multiethnic Cohort Study
10.1093/aje/kwk069 · 2007 · External reference
Consumption of dairy products and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
10.1371/journal.pone.0072715 · 2013 · External reference
Independent associations of dairy and calcium intakes with colorectal cancers in the Adventist Health Study-2 cohort
10.1017/s1368980017001422 · 2017 · External reference
A colorectal cancer diet quality index is inversely associated with colorectal cancer in the Malm? diet and cancer study
10.1097/cej.0000000000000486 · 2019 · External reference
Dairy products and colorectal cancer. a review of possible mechanisms and epidemiological evidence
10.1038/sj.ejcn.1601522 · 2003 · External reference
Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26335 cases from 60 observational studies
10.1080/01635580802395733 · 2009 · External reference
Dairy products and colorectal cancer risk: a systematic review and meta-analysis of cohort studies
10.1093/annonc/mdr269 · 2012 · External reference
Foods and beverages and colorectal cancer risk: a systematic review and meta-analysis of cohort studies, an update of the evidence of the WCRF-AICR Continuous Update Project
10.1093/annonc/mdx171 · 2017 · External reference
Food groups and risk of colorectal cancer
10.1002/ijc.31198 · 2018 · External reference
Dairy consumption and risks of colorectal cancer incidence and mortality: a meta-analysis of prospective cohort studies
10.1158/1055-9965.epi-20-0127 · 2020 · External reference
Dairy consumption and risk of conventional and serrated precursors of colorectal cancer: a systematic review and meta-analysis of observational studies
10.1155/2021/9948814 · 2021 · External reference
The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population
10.1136/gut.2004.055939 · 2005 · External reference
The association of lactose intolerance with colon and gastric cancers: friend or foe?
10.7759/cureus.24713 · 2022 · External reference
Dairy products and cancer risk in a northern Sweden population
10.1080/01635581.2019.1637441 · 2020 · External reference
Consumption of yoghurt and other dairy products and risk of colorectal cancer in Iran: the IROPICAN Study
10.3390/nu14122506 · 2022 · External reference
Dairy product consumption and risk of cancer: a short report from the NutriNet-Santé prospective cohort study
10.1002/ijc.33935 · 2022 · External reference
Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people
10.1186/s12916-022-02330-3 · 2022 · External reference
Yogurt consumption and risk of colorectal cancer in the Italian European prospective investigation into cancer and nutrition cohort
10.1002/ijc.26193 · 2011 · External reference
Higher yogurt consumption is associated with lower risk of colorectal cancer: a systematic review and meta-analysis of observational studies
10.3389/fnut.2021.789006 · 2021 · External reference
Fermented dairy food intake and risk of colorectal cancer: a systematic review and meta-analysis
10.3389/fonc.2022.812679 · 2022 · External reference
Yogurt consumption and colorectal polyps
10.1017/s0007114520000550 · 2020 · External reference
Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer
10.1136/gutjnl-2019-318374 · 2020 · External reference
Colorectal cancer and nonfermented milk, solid cheese, and fermented milk consumption: a systematic review and meta-analysis of prospective studies
10.1080/10408398.2011.629353 · 2014 · External reference
Yogurt consumption and colorectal cancer incidence and mortality in the Nurses’ Health Study and the Health Professionals Follow-Up Study
10.1093/ajcn/nqaa244 · 2020 · External reference
Food groups, diet quality and colorectal cancer risk in the Basque Country
10.3748/wjg.v26.i28.4108 · 2020 · External reference
Postdiagnostic dairy products intake and colorectal cancer survival in US males and females
10.1093/ajcn/nqab059 · 2021 · External reference
High lactose whey cheese consumption and risk of colorectal cancer - The Norwegian Women and Cancer Study
10.1038/s41598-018-36445-6 · 2019 · External reference
Antioxidant potential of buffalo and cow milk Cheddar cheeses to tackle human colon adenocarcinoma (Caco-2) cells
10.5713/ajas.17.0031 · 2018 · External reference
Kefir exhibits antiproliferative and proapoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
10.3892/ijo.2014.2635 · 2014 · External reference
Supplementation of kefir ameliorates azoxymethane/dextran sulfate sodium induced colorectal cancer by modulating the gut microbiota
10.1039/d1fo01729b · 2021 · External reference
The protective effects of fermented kefir milk on azoxymethane-induced aberrant crypt formation in mice colon
10.1016/j.tice.2018.03.013 · 2018 · External reference
Kefir reduces the incidence of pre-neoplastic lesions in an animal model for colorectal cancer
10.1016/j.jff.2018.11.050 · 2019 · External reference
Preclinical evidence of probiotics in colorectal carcinogenesis: a systematic review
10.1007/s10620-020-06062-3 · 2020 · External reference
Preclinical and clinical relevance of probiotics and synbiotics in colorectal carcinogenesis: a systematic review
10.1093/nutrit/nuz087 · 2020 · External reference
Relationship between gut microbiota and colorectal cancer: probiotics as a potential strategy for prevention
10.1016/j.foodres.2022.111327 · 2022 · External reference
Molecular mechanisms of postbiotics in colorectal cancer prevention and treatment
10.1080/10408398.2020.1765310 · 2021 · External reference
Lactobacillus casei exerts anti-proliferative effects accompanied by apoptotic cell death and up-regulation of TRAIL in colon carcinoma cells
10.1371/journal.pone.0147960 · 2016 · External reference
Immunomodulatory effect of Lactobacillus casei in a murine model of colon carcinogenesis
10.1007/s12602-019-09611-z · 2020 · External reference
Extract of Lactobacillus plantarum strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells
10.1016/j.bbrep.2019.100691 · 2019 · External reference
Lactiplantibacillus plantarum-12 alleviates inflammation and colon cancer symptoms in AOM/DSS-treated mice through modulating the intestinal microbiome and metabolome
10.3390/nu14091916 · 2022 · External reference
Lacticaseibacillus rhamnosus—a promising tool for colorectal cancer treatment
10.3390/pr11030781 · 2023 · External reference
Lactobacillus rhamnosus confers protection against colorectal cancer in rats
10.4314/tjpr.v18i7.12 · 2021 · External reference
Lactobacillus acidophilus CGMCC 878 impacts colorectal cancer in Sprague-Dawley rats through changing the gut microbiota
10.1016/j.medmic.2022.100062 · 2022 · External reference
Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1
10.1016/j.jff.2016.01.016 · 2016 · External reference
Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis
10.1186/s13046-023-02746-6 · 2023 · External reference
Bifidobacterium longum suppresses murine colorectal cancer through the modulation of oncomiRs and tumor suppressor miRNAs
10.1080/01635581.2019.1577984 · 2019 · External reference
Yacon flour (Smallanthus sonchifolius) attenuates intestinal morbidity in rats with colon cancer
10.1016/j.jff.2017.08.039 · 2017 · External reference
Traditional processed meat products re-designed towards inulin-rich functional foods reduce polyps in two colorectal cancer animal models
10.1038/s41598-019-51437-w · 2019 · External reference
Metagenomic analysis of gut microbiota modulatory effects of jujube (Ziziphus jujuba Mill.) polysaccharides in a colorectal cancer mouse model
10.1039/c9fo02171j · 2020 · External reference
Novel combination of prebiotics galacto-oligosaccharides and inulin-inhibited aberrant crypt foci formation and biomarkers of colon cancer in Wistar rats
10.3390/nu8080465 · 2016 · External reference
Synbiotic VSL#3 and yacon-based product modulate the intestinal microbiota and prevent the development of pre-neoplastic lesions in a colorectal carcinogenesis model
10.1007/s00253-020-10863-x · 2020 · External reference
Cancer-protective effect of a synbiotic combination between Lactobacillus gasseri 505 and a Cudrania tricuspidata leaf extract on colitis-associated colorectal cancer
10.1080/19490976.2020.1785803 · 2020 · External reference
Germinated brown rice combined with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis inhibits colorectal carcinogenesis in rats
10.1002/fsn3.864 · 2019 · External reference
Probiotic/synbiotic treatment and postoperative complications in colorectal cancer patients: systematic review and meta-analysis of randomized controlled trials
10.14309/ctg.0000000000000268 · 2020 · External reference
Safety of probiotics in patients receiving nutritional support: a systematic review of case reports, randomized controlled trials, and nonrandomized trials
10.3945/ajcn.2009.28759 · 2010 · External reference
Cancer preventive effects of a specific probiotic fermented milk containing Lactobacillus acidophilus CL1285
10.1016/j.jff.2015.06.035 · 2015 · External reference
Bifidobacterium longum subsp. longum YS108R fermented milk alleviates DSS induced colitis via anti-inflammation
10.1016/j.jff.2020.104153 · 2020 · External reference
Protective effects of potential probiotic Lactobacillus rhamnosus (MTCC-5897) fermented whey on reinforcement of intestinal epithelial barrier function in a colitis-induced murine model
10.1039/d0fo02641g · 2021 · External reference
Intake of Bifidobacterium longum and Fructo-oligosaccharides prevents Colorectal Carcinogenesis
10.5005/jp-journals-10018-1251 · 2018 · External reference
Synbiotic sheep milk ice cream reduces chemically induced mouse colon carcinogenesis
10.3168/jds.2020-19979 · 2021 · External reference
Effect of a high-fat diet in development of colonic adenoma in an animal model
10.3748/wjg.v20.i25.8119 · 2014 · External reference
High-fat diet accelerates intestinal tumorigenesis through disrupting intestinal cell membrane integrity
10.15430/jcp.2016.21.2.95 · 2016 · External reference
Association between dietary fat intake and colorectal cancer: a multicenter case-control study in Iran
10.3389/fnut.2022.1017720 · 2022 · External reference
The interaction between dietary fiber and fat and risk of colorectal cancer in the women’s health initiative
10.3390/nu8120779 · 2016 · External reference
Associations of red meat, fat, and protein intake with distal colorectal cancer risk
10.1080/01635581003605938 · 2010 · External reference
Dietary fat intake and risk of colorectal cancer: a systematic review and meta-analysis of prospective studies
10.3390/nu10121963 · 2018 · External reference
Dairy product consumption and risk of colorectal cancer in an older mediterranean population at high cardiovascular risk
10.1002/ijc.31540 · 2018 · External reference
High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography Cohort
10.1093/ajcn/82.4.894 · 2005 · External reference
Association between dairy product consumption and colorectal cancer risk in adults: a systematic review and meta-analysis of epidemiologic studies
10.1093/advances/nmy114 · 2019 · External reference
Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society
10.3322/caac.21457 · 2018 · External reference
Association between metabolic syndrome and the risk of colorectal cancer diagnosed before age 50 years according to tumor location
10.1053/j.gastro.2022.05.032 · 2022 · External reference
Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women
10.1136/gutjnl-2020-323450 · 2021 · External reference
Kefir modulates gut microbiota and reduces DMH-associated colorectal cancer via regulation of intestinal inflammation in adulthood offsprings programmed by neonatal overfeeding
10.1016/j.foodres.2021.110708 · 2022 · External reference
Adolescent and mid-life diet: risk of colorectal cancer in the NIH-AARP Diet and Health Study
10.3945/ajcn.111.020701 · 2011 · External reference
School milk and risk of colorectal cancer: a national case-control study
10.1093/aje/kwq390 · 2011 · External reference
Dairy intake during adolescence and risk of colorectal adenoma later in life
10.1038/s41416-020-01203-x · 2021 · External reference
Assessing the contribution of nine preventable risk factors attributed to the burden of early onset colorectal cancer in Gulf Cooperation Council (GCC) countries
10.1016/j.pmedr.2023.102389 · 2023 · External reference
Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer
10.1097/aln.0000000000000393 · 2014 · External reference
Prehabilitation with whey protein supplementation on perioperative functional exercise capacity in patients undergoing colorectal resection for cancer: a pilot double-blinded randomized placebo-controlled trial
10.1016/j.jand.2015.06.007 · 2016 · External reference
Multimodal prehabilitation improves functional capacity before and after colorectal surgery for cancer: a five-year research experience
10.1080/0284186x.2016.1268268 · 2017 · External reference
Feasibility and efficiency of the BEFORE (better exercise and food, better recovery) prehabilitation program
10.3390/nu13103493 · 2021 · External reference
Adherence to and efficacy of the nutritional intervention in multimodal prehabilitation in colorectal and esophageal cancer patients
10.3390/nu15092133 · 2023 · External reference
Comparing the associations of dietary patterns identified through principal component analysis and cluster analysis with colorectal cancer risk: a large case-control study in China
10.3390/nu16010147 · 2023 · External reference
Do low-fat foods alter risk of colorectal cancer from processed meat?
10.1016/j.puhe.2020.03.026 · 2020 · External reference
Dietary patterns and colorectal cancer risk: a review of 17 years of evidence (2000-2016)
10.1007/s11888-017-0390-5 · 2017 · External reference
Hypothesis and data-driven dietary patterns and colorectal cancer survival: findings from Newfoundland and Labrador colorectal cancer cohort
10.1186/s12937-018-0362-x · 2018 · External reference
Dietary patterns and risk of colorectal cancer: a comparative analysis
10.1093/ije/dyac230 · 2023 · External reference
Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
10.1038/s41598-023-50567-6 · 2024 · External reference